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H Salzer

Publications and source records attributed to H Salzer.

At least 109 records · Page 6Linked to original sources
PubMed1983

[The importance of hormone receptor analysis for diagnosis and therapy of gynecologic malignancies].

Determination of the tissue concentration of hormone receptors in gynaecological malignancies has achieved a great importance over the past few years. In carcinoma of the breast this not only constitutes an excellent prognostic parameter, receptor-positive cases usually having a much better prognosis, but also reliably predicts the response to endocrine treatment: the higher the receptor concentration, the higher the remission incidence under hormonal treatment. With regard to the response to chemotherapeutic treatment the predictive value of receptor determinations is still a matter of dispute. In both carcinoma of the breast and carcinoma of the endometrium there is a good correlation between the degree of differentiation and the concentration of receptors. Since the response to treatment with progestational agents depends on the concentration of progesterone receptors, induction of this receptor by means of antioestrogenic medication can be used therapeutically. In ovarian carcinoma a similar distribution of hormone receptors is found. Whether receptor concentration in ovarian carcinoma is related to prognosis and response to endocrine treatment is still under investigation. It can be assumed that determination of hormone receptor concentrations will become an integral part of the management of gynaecological malignancies.

Breast Neoplasms↗
PubMed1983

[Long-term experience in the therapy and prevention of unspecific vaginal discharge with a Lactobacillus vaccine].

This report presents a study of 28 women with chronic non-specific vaginitis treated by Solco Trichovac, a vaccine containing at least 7 X 10(9) inactivated microorganisms of various strains of Lactobacillus acidophilus in each 0.5 ml dose. 3 injections were administered at 2-week intervals, and the results of therapy investigated with regard to quantitative increase in lactobacilli in the vaginal secretion, change in grade according to Schröder and reduction of the vaginal fluor. The vaccination caused a significant (p less than 0.01) quantitative increase in physiological lactobacilli. Accordingly, there was a significant improvement (p less than 0.01) in grade already 4 weeks after completion of the primary course of treatment. Re-examination after one year showed that nearly 80% of the patients were grade I to II; the vaginal fluor was clinically cured or at least markedly improved in 85.6% of cases. In our experience the vaccination presents a promising new concept of therapy and shows a special effect in patients with chronic non-specific vaginitis and with reduced Döderlein's vaginal bacillus due to restoration of the biological protective mechanisms.

Adolescent↗
PubMed1983

[Amniotic fluid cytology and foetal lung maturity--a comparison with the dynamic surface tension measurement of the amniotic fluid for predicting foetal lung maturity].

79 samples of amniotic fluid in 69 pregnancies between 29-40 weeks of gestation were examined for foetal lung maturity (dynamic surface tension) and general maturity (Nile Blue cytological test). Both parameters were compared with the pulmonary maturity of the newborn post partum in 24 cases born within 72 hours after the last amniotic fluid examination. In 49 cases the Nile Blue cytological test showed mature values, in 24 cases immature - and in 6 cases borderline values. The dynamic surface tension measurement showed 55 mature, 19 immature and 5 borderline results. These findings show an earlier maturation of the foetal lung compared with the foetal sebaceous glands. Between 36 and 40 weeks of gestation we found a significant (p less than 0.01) correlation between the two methods. Between 32 and 35 weeks of gestation, the significance was less (p less than 0.05) and between 29 and 31 weeks of gestation no correlation could be found. The Nile Blue cytological test for lipid cells is easy to perform, requires less than 1 ml amniotic fluid and is not influenced by blood and meconium and shows no false positive results. Immature findings with the Nile Blue cytological test should be confirmed by other lung maturity tests, like LS-ratio or amniotic dynamic tension measurement. Therefore we can recommend this simple method for the screening of foetal lung maturity as well.

Amniotic Fluid↗
PubMed1983

Estrogen - and gestagen - receptors in ovarian carcinoma.

Estrogen (ER) - and progestagen (PgR) - receptors were estimated by a DCC method using Scatchard plot analysis In tissue samples of 68 patients with ovarian carcinomas. The mean ER and PgR levels were at 52 and 74 fmol/mg cytosol protein, respectively. ER+ PgR+ records were noted in 32.4%, ER+ PgR- in 26.4%, ER- PgR+ in 7.4%, and 33.8% presented with ER- PgR-. In the surviving group 44.1% had Er+ PgR+, whereas the patients who died had an incidence of only 20.5% ER+ PgR+. In addition, the incidences of ER+ PgR+ in stage I plus II and stage III plus IV patients were 42.6 and 29.5%, respectively. Furthermore, higher incidences of ER+ PgR+ were recorded in patients older than 60 years of age (63%) than in younger subjects (36%). The present data combine to suggest that receptor assays should become a useful tool in the management of patients bearing ovarian carcinomas. In addition, ER and PgR determinations provide a prognostic index and may improve the possibility to predict which well-differentiated stage I ovarian carcinomas are likely to recur.

Female↗
PubMed1983

Relationships among human amniotic fluid dipalmitoyl lecithin, postpartum respiratory compliance, and neonatal respiratory distress syndrome.

The major molecular species of amniotic fluid phosphatidylcholine were determined as diacylglycerol trimethylsilyl ether derivatives by gas-liquid chromatography with use of glass capillary columns. We studied amniotic fluid specimens from 48 pregnancies. As expected, the major disaturated species of amniotic fluid phosphatidylcholine, dipalmitoylphosphatidylcholine, and palmitoylmyristoylphosphatidylcholine increased with gestational age, whereas phosphatidylcholine species with 34, 36, and 38 carbon atoms in the acyl radicals decreased. Although the amniotic fluid samples were obtained shortly before parturition (4.2 +/- 3.7 h, mean +/- SD), the correlation between dipalmitoylphosphatidylcholine concentration in amniotic fluid and gestational age was better than between dipalmitoylphosphatidylcholine concentration and the compliance of the respiratory system of the newborns. In addition, the percentage of amniotic fluid phosphatidylcholine species present as dipalmitoylphosphatidylcholine seemed to be a more reliable predictor of lung maturity than was the absolute dipalmitoylphosphatidylcholine concentration in amniotic fluid.

Amniotic Fluid↗
PubMed1982

[Analysis of dipalmitoyl-phosphatidyl-choline (DPPC) in amniotic fluid: a new sensitive method for surfactant determination].

The surface active alveolar system (surfactant) is of central importance for normal lung function in newborn infants and its lack remains a frequent cause of perinatal mortality and morbidity in premature infants, as well as those born at term. The most important substance of this system is the lecithin dipalmitoyl-phosphatidyl-choline (DPPC). Many different methods to obtain information concerning lung maturity through analysis of phospholipids in the amniotic fluid have been tested, but all of them give only indirect assessment of the DPPC content. A new method for the separation and quantification of DPPC and the other lecithins in amniotic fluids is presented. This capillary gas-chromatographic procedure enabled a comparison of these parameters with the postpartum pulmonary condition of the newborn infants. It was found that the di-saturated lecithin PC 30 increases with increasing lung maturity and plays a major role in the surfactant complex, together with DPPC and PC 34, which are inter-related. Of all chemical methods for analysis of amniotic fluid, gas-chromatographic determination of the concentration of DPPC and PC 30 constitutes the best parameter for prediction of fetal lung maturity.

Amniotic Fluid↗
PubMed1982

Respiratory compliance of newborns after birth and its prognostic value for the course and outcome of respiratory disease.

The compliance of the respiratory system was determined at an average of 2.89 h (range 45 min - 8 h) after birth in 82 newborns who were retrospectively divided into group 1: healthy newborns (mean gestational age 37.1 weeks, range 30 - 41 weeks); group 2: newborns with respiratory distress (RD) needing no ventilatory support (mean gestational age 37.3 weeks, range 35--40 weeks); group 3: newborns with RD needing ventilatory support and surviving (mean gestational age 34.3 weeks, range 30--39 weeks), and group 4: newborns with RD who needed ventilatory support and died (mean gestational age 30.8 weeks, range 28--37 weeks). Respiratory compliance was measured by the airway occlusion technique in spontaneously breathing babies and by injecting a known volume of gas into the closed airway system and measuring airway pressure in intubated babies. The difference in postnatal compliance was statistically significant (p less than 0.01) in those four groups and was correlated with the severity of the disease in groups 2 and 3. In infants with RD, compliance was highly predictive for the need for ventilatory support (93% correct and 7% erroneous) and in infants with ventilatory support, for the mortality (83% correct and 17% erroneous). We conclude that postnatal compliance measurements are very useful to predict the course and outcome as well as to classify the severity of RD.

Gestational Age↗
PubMed1982

The relationship of prolactin in cord blood, gestational age and respiratory compliance after birth in newborn infants.

In 29 healthy newborns (gestational age 30-41 weeks) and 7 newborns with respiratory distress syndrome (gestational age 28-31 weeks) the prolactin levels in the cord blood and respiratory compliance was measured. Prolactin was determined by radioimmunoassay, the respiratory compliance was measured with the airway occlusion technique in spontaneously breathing newborns and with injection of known volumes and measuring the airway pressure in newborns with ventilatory support. In healthy newborns prolactin and gestational age were significantly correlated (r = 0.62, p less than 0.001), while prolactin did not correlate with respiratory compliance (r = 0.22, n. s.). Comparing 5 healthy newborns and the 7 RDS infants with prolactin values below 170 ng/ml, there was no significant difference in the prolactin levels, but in the compliance values. We conclude that prolactin does not directly influence lung maturation, but is associated with gestational age.

Fetal Blood↗
PubMed1982

[New aspects in the diagnosis and therapy of fetal lung immaturity. Determination of the infant respiratory system compliance. Analysis of dipalmitoylphosphatidylcholine in amniotic fluid. Use of carnitine for the enhancement of lung maturation. (Clinical and experimental results)].

The surfaceactive alveolar system (surfactant) is of central importance for a normal lung function of premature and neonates. The most important substance of this system consisting of phospholipids and lecithin is Dipalmitoyl-Phosphatidyl-Cholin (DPPC) because it specially lowers the surface tension in the alveola. A lack of surfactant leeds to the respiratory distress syndrome (RDS) of newborns which today still remains the most frequent cause of death of prematures. Many different methods have been tried to get information concerning lung maturity through analysis of phospholipids in the amniotic fluid; more over strong efforts have been made to stimulate surfactant production pharmacologically in case of diagnosed fetal lung immaturity. Corticosteroids have proven to be effective for this induction and are excepted world wide; however possible adverse effects on the mother and her fetus have let to discussions about the use of corticosteroids. Therefore the effect of Carnitine on fetal lung maturation in sheep was investigated in the experimental part of this study. The clinical part was devoted to other problems.

Amniotic Fluid↗
PubMed1982

[The infant of the diabetic mother. A current reevaluation (author's transl)].

In the past fifteen years several aspects of the diabetogenic fetopathia have changed. Tight metabolic control during pregnancy approaching normoglycemia was followed by a continuous decline in perinatal mortality. However, the evaluation of pregnancy outcome beyond statistical analyses still reveals some pertinent questions: They state to the increased incidence of congenital malformations, the pre- and postnatal diagnosis of significant gestational diabetes, the heterogeneity of impaired intrauterine growth and development and the late outcome of these children.

Congenital Abnormalities↗
PubMed1981

[Intrauterine contraception with copper-T 200 device- a retrospective analysis of 334 cases (author's transl)].

A review is given of the findings obtained in 334 women in whom a Cu-T 200 intrauterine device had been inserted at least two years previously and regular follow-up examinations were subsequently undertaken. The most frequent indications were an expressed preference for IUD on the patient's part (38.3%), poor tolerance to the "pill" (24.8%) and so-called "pill fatigue" (11.1%). Varicose veins led to IUD preference in 8.1% and thromboembolic disease in 6.-%. The failure rate - with 12 pregnancies - was 3.6%, all within 6 months of insertion of the device. Half of the pregnancies went to full term and resulted in the birth of mature, healthy babies. The most frequent complication were menstrual disturbances (20.1%). pain (19.5%), cervicitis (18.3%), and adnexitis (13.8%), necessitating removal of the device in 5.7%, 4.2%, 5.1%, and 0.6% of all cases for the afore-mentioned reasons, respectively. These rates are relatively high. The expulsion rate of 2.7% was relatively low, however. Further analysis of the complications led to the observation that menorrhagia was relatively common in nulliparae and in women with retroversion of the uterus, whereas the pre-insertion finding of a pressure-sensitive uterus with a normal ESR, led in a significantly higher percentage of cases to pain and adnexitis. The diagnosis by vaginal probe of a reduced uterine length led to faulty positioning and an increased tendency to pain in a significantly higher number of cases. The fact that only 56.6% of all women tolerated intrauterine contraception well and remained totally symptom-free supports th view held by us that even today the "pill" remains the contraceptive of choice and should be recommended as such.

Female↗
PubMed1981

[Functional and hormonal differences between group I and group II amenorrhoea (WHO classification) (author's transl)].

77 amenorrhoeic women were classified as responding positively or negatively to clomiphene. The results of iterative LRH tests and studying feed-back reactions to steroid administration showed that the two collectives strictly correspond to groups I and II of the WHO classification of amenorrhoea. The LH response to the LRH test was significantly higher in group II than in group I, while there was no difference between the two groups in the FSH response. Oestradiol 17 beta was significantly higher in group II than in group I, but both groups showed a significant increase in E2 three hours after the LRH test. The possible mechanisms of LH production and pool formation, as well as FSH regulatory factors are discussed. This paper demonstrates that clomiphene appears to be ideally suited as a test substance for the classification of amenorrhoea according to its degree of severity.

Adult↗
PubMed1981

[Optical density and surface tension in amniotic fluid in the late pregnancy (author's transl)].

113 amniotic fluid samples from pregnant women between the 28th and the 41st week of gestation were examined for optical density and surface tension. Surface tension measurement was done by means of the Wilhelmy-balance which shows a very good correlation with the L/S-ratio. Optical density was measured at 405, 580, 650, 750 and 900 nm wave length. For the comparison with the surface tension optical 650 nm was used, since at this wave length only minimal absorbance of known biologic pigments occurs. Pulmonary maturity was diagnosed when the surface of the hysteresis area (dynamic surface tension measurement) was more than 20 cm2 or when optical density at 650 nm was false positive in 3,7% and false negative in 40,7%. The same percentage was found in the predication of fetal lung maturity by this method after fetal outcome. The measurement of the optical density is a rapid and simple method, but because of the high number of false negative results it is advised to use one of the more sophisticated methods for the prediction of fetal lung maturity in cases of a negative optical density reading at 650 nm.

Amniotic Fluid↗
PubMed1981

Abdominal decompression. An approach towards treating placental insufficiency.

The effects of abdominal decompression applied over a period of several weeks (mean 4 weeks) in late pregnancy on biochemical and haemodynamic parameters as well as fetal growth and cardiotocogram patterns were studied in a group of 64 pregnant women with identified placental insufficiency. A statistically significant improvement was demonstrated in the following findings after treatment: placental perfusion measurements 113mIn and unconjugated oestriol and human placental lactogen, both in serum. A positive influence on antepartum cardiotocogram was observed only immediately after therapy. An acceleration of fetal growth (biparietal diameter) could not be demonstrated. Frequency and severity of EPH gestosis did not change after abdominal decompression. Abdominal decompression seems to be a valuable aid in the still unsatisfactory treatment of placental insufficiency.

Abdomen↗
PubMed1981

[The influence of beta-mimetics on foetal pulmonary maturing (author's transl)].

Amniocentesis was carried out in 99 patients between the 31st to the 32nd gestational week in order to determine lung maturity. We subdivided the patients into 5 groups 11 women were treated with Hexoprenaline, 12 with Ritodrine, 26 with Dexamethason for acceleration of lung maturity, 23 with Dexamethason and beta-mimetics and 27 women were controls. A significant rise of surfactant factor measured by surface tension by means of the Wilhelmy-balance could be demonstrated in the two groups receiving glucocorticoids, whereas in the other groups the rise of surfactant factor corresponded with the usual increase due to age of gestation. But concerning the incidence and intensity of RDS and intensity, the best results were observed in the group with Dexamethason only. Increase of surfactant factor and incidence of RDS in groups with tocolytics and in the controls were similar, therefore we conclude, that beta-mimetics do not have an influence on lung maturity. A relatively high incidence of mild RDS-cases in the group of Dexamethason combined with tocolytics should be a warning to use both drugs routinely together.

Adrenergic beta-Agonists↗