[The value of umbilical cord blood cortisol].
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Biomedical subjects
Publications and source records attributed to H Rosegger.
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Out of 1071 investigated patients had antibodies in 73.7% against Cytomegalovirus. 99 ambulant Kala-Azar-patients reacted positive in 33%. Inhabitants of different villages have shown 35.2 to 50% positive reactions. Patients with hepato-splenomegaly in 94% and patients with diarrhoea and fever in 81% were positive.
In the present paper the occurrence of different species of Pseudomonas, of Acinetobacter calcoaceticum var. anitratum and Aeromonas hydrophila in hospitals is described. The possible human pathogenic significance is discussed.
After testing various chemotherapeutics the following conclusions could be drawn: Pseudomonas was sensitive only to gentamicin. Gentamicin, aminopenicilline + calvulanacid and cefoxitin were 100% effective against E. coli. Gentamicin also proved effective against Enterobacter (83%). Cefoxitin, aminopenicillin + clavulanacid, gentamicin and trimethoprim + sulfonamide were effective against Klebsiella. Concerning Proteus sp., cefoxitin showed best results (100%). Acinetobacter was 100% inhibited by gentamicin. Gentamicin was most effective (93% sensitivity) against Staph. aureus. Trimethoprim + sulfonamide and erythromycine showed resistance rate of 17%, cefalosporine and isoxazolylpenicilline a rate of 21%. Aminopenicillin and aminopenicilline + calvulanacid were most suitable against Enterococcus (100%).
We report on 143 newborns of mothers with insulin dependent diabetes during pregnancy. The mean birth weight was 3.091 (+/- 619) g at a mean gestational age of 38.4 (+/- 2) weeks. Neonatal morbidity was associated with the disease class, insulin levels in the amniotic fluid, urine and cord blood; and especially persistent fetal hyperinsulinism as indicated by repeatedly high amniotic fluid insulin levels during pregnancy. One infant died (neonatal mortality 0.69%) of a severe cardiac malformation combined with a caudal regression syndrome. This was the only major malformation in the group.
In this report the possibilities for the application of PVP-iodine-preparations in the developing countries in the treatment of wounds, including burns and in diseases of the mucous membrane, eyes, mouth and genital region are discussed. The application proved particularly valuable where a high antibiotic resistance was found.
In Sudan, measles are often not identified and are diagnosed and treated as "fever". Apart from this, the unimmunized population is an important factor, however, cold storage of the vaccine is not always possible. For this reason detailed instruction and introduction in diagnostic identification was given by our team of doctors. The contamination rate and antibody verification varies according to region. The highest percentage of 83% was reached in Melut among hospitalized patients. At the time of our investigation, immunization had not been carried out in this region.
In the Melut district, South Sudan human and animal blood samples were investigated for Brucella abortus and Brucella melitensis. 9.2% of the investigated cattle and 16.2% of the green long-tailed monkies were Brucella abortus-positive. School children revealed a 3.7% positivity rate, Melut's hospital patients 5.2% and village children and adults 2.2%. However, only a small number of hospital patients was investigated. A small percentage of sheep and goats was investigated for Brucella melitensis revealing 12% positive results. 8.7% of cattle were positive. 2.2% of school children reacted in high titers against Brucella melitensis, 5.2% of Melut's patients and in the Melut district 3.6% of children and adults.
Pulmonary lavage - a supplementary measure of resuscitation in newborn infants with severe aspiration of meconium stained amniotic fluid. During 1984-1985 150 mature newborn infants who had aspirated heavily-stained or pea soup-like amniotic fluid were resuscitated at the University Hospital of Obstetrics and Gynaecology in Graz. In 109 of these infants (controls) routine aspiration of both the upper and lower airways was accomplished as soon as possible, whilst in the remaining 41 infants (lavaged) pulmonary lavage with saline was additionally performed via an endotracheal tube after aspiration to clear the trachea and the upper bronchi from thick meconium which could not have been removed as efficiently otherwise. The incidence of manifest meconium aspiration syndrome was significantly higher (22%) in the lavaged infants than in the controls (8%). Mechanical ventilation was performed in 36% of the lavaged infants, whereas only 5.5% of the controls had to be ventilated for more than 1 hour. The mean duration of ventilation, however, was shorter (Mh = 5.1 hrs vs Mh = 69 hrs) and the average age at discharge lower in the lavaged. Three infants died, two of whom had severe malformations. Only one death in the lavaged infants was attributable to severe meconium aspiration syndrome already manifest at birth. Three infants (two lavaged, one control) showed radiological evidence of pneumothorax, but without clinical appearance of respiratory distress. Since the lavaged group naturally contained the more severely distressed infants, with a high incidence of caesarean section on account of intrauterine asphyxia and lower Apgar scores at one and five minutes, the high incidence of radiologically confirmed meconium aspiration syndrome was not surprising.(ABSTRACT TRUNCATED AT 250 WORDS)
Studies of diseases associated with diarrhoea in the Melut district of South Sudan in the years 1981-1982 showed amoebic dysentery and Rota-virus to be predominate, whereby according to our previous results Yersinia, Campylobacter, Shigella and Salmonella infections also play a role. In addition other parasitological bacterial and viral-infections are presumed.
In serological investigations undertaken in two hospitals in Nigeria a total of 188 blood samples were examined and the following positive reactions for various diseases found: malaria 100%, leishmaniasis 9.5%, biharziasis 2.1%, yersinia 16.4%, Legionella pn. 9%, gonorrhea 6%, syphilis 6.9%, measles 65.4%, rubella 84%, cytomegalic 78.2%, herpes simplex 67%, varicella 30.8%, Resp. sync. virus 34.6%, influenza A 57.4%, influenza B 73.9%, para-influenza 1, 2, 3, 20.7%, 16.5%, 52.6%, adenovirus 25%, Mycoplasma pneumoniae 33.5%.
176 blood sera taken from patients in the hospital of Minna and Abeokuta (Nigeria) were examined for anthropozoonoses. The following positive reactions could be found: Brucella abortus 9%, Brucella melitensis 11.7%, Echinococcosis 0.53%, Toxoplasmosis 79.2% (CF-Test 6.9%), Chlamydial diseases 45%, Listeriosis 28.7% (Typ 1H) and 19.7% (Typ 4bH), Rickettsiosis--Rickettsia conori 18.6% and Coxiella burneti 63.3%.
188 blood samples were investigated for antibodies against bacteria causing diarrhoea in two hospitals in Minna and Abeokuta in Nigeria. Antibodies were found against Entamoeba histolytica, Yersinia enterocolitica, Campylobacter jejuni, Salmonella typhi, Salmonella paratyphi C, Shigella dysenteriae, Shigella sonnei, Shigella boydii, Shigella flexneri and Rotavirus.
23,939 children born consecutively at the Department of Obstetrics and Gynaecology, University of Graz, over a 5-year period ending 31. 12. 1984 were surveyed for the presence of major malformations. 394 (1.6%) had a major congenital defect. Within the same time 392 infants died during the perinatal period, 86 of them being malformed (22%). The malformations were listed according the most likely mode of inheritance, revealing a total of 80 different congenital defects. About 70% of these malformations are associated with an increased recurrence risk (greater than 1%) and 15% carry a high risk of recurrence (greater than 10%). These facts point to the importance of prenatal diagnosis and proper genetic counselling.
Cardiac function was investigated in 23 retrospectively selected children (mean age 15 months, range 2/12-3 4/12), whose mothers had undergone a successful course of tocolysis around the 31st week of pregnancy. Hexoprenaline sulfate (Gynipral) had been given at a mean cumulative dose of 51,103 micrograms over an average period of 13.8 days. The infants were born at term; cases with marked birth asphyxia, low birth weight or other perinatal problems possibly influencing cardiac performance were not included. The examination included a chest X-ray, ECG (all standard leads) and ultrasonography. There was no evidence of myocardial dysfunction which might have been the late result of untoward effects of the beta 2-mimetics given during the last trimester of pregnancy. All probands were normally developed: on cardiological examination an incidental systolic murmur was found in 2 infants and border-line cardiomegaly in another proband. ECG revealed a wandering pace-maker and occasional ventricular extrasystoles in one 3 month-old boy, which is not necessarily abnormal at this age. Two-dimensional echocardiography showed normal cardiac anatomy in all 23 probands. One-dimensional M-mode showed normal left ventricular function parameters. The slightly elevated myocardial contractility demonstrated by means of the M-mode was attributed to increased sympathetic tone in the non-sedated children.
200 mature healthy newborn infants (birthweight 3382 +/- 377 g) were randomly divided into 2 groups of 100 each: all were breast fed according to the guidelines recommended by 'La Leche League'. If possible breast feeding was commenced in the delivery room. When breast feeds did not suffice infants of group A were supplemented ad libitum with a fully adapted formula (67 kcal/dl), those of group B with a 13% maltodextrine solution (52 kcal, 160 mOsm/l). Total fluid intake was similar in both groups. Group A took less supplementary feeds on day 2, the caloric uptake, however, was not different from that of group B. On day 4 group A had a somewhat higher caloric uptake due to supplementation, whereas group B needed less supplementation but had a higher intake of breast milk. On day 5 all babies were entirely breast fed. No supplementation was handed over to the mothers for at home use. The frequency of breast meals and supplementary meals was almost equal for both groups, as were sucking activity, appetite and degree of saturation. 18.6% of the infants in both groups had no need for any supplementary feeding at all. Temperature, stools, weight loss, blood glucose and bilirubin (taken on day 4 simultaneously with the Guthrie test) were almost identical. The red blood cell count showed slightly higher values in group A. Supplementation with fully adapted formula was not advantageous over supplementation with 13% maltodextrine solution. The latter was, indeed, tolerated well in all cases and satisfied all infants who remained hungry after being breast fed; additional early exposure to cow-milk protein was, thus, avoided in all these cases.