Do we need firm compression stockings exerting high pressure?
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Biomedical subjects
Publications and source records attributed to H Partsch.
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Disturbances observed int he thermoregulation of replanted extremities were the stimulus for this experimental study. We chose the auricular conchae of rabbits as an experimental model, as these show--as do the fingers--innervation with the sympathic nervous system and fulfil thermoregulatoric functions. Twenty-five of thirty auricular conchae of rabbits took completely after amputation and replantation. Blood flow measurements with 133 Xenon, thermographic and histologic examinations were performed. Thermography showed dysfunction with temperature provocation even one year after replantation. Histological examinations revealed partly deficient reinnervation in vessels and also in cutaneous appendages.
Indirect lymphography with Iotasul (interdigital, intradermal infusion) was performed in 32 patients with lymphedema. No side effects were observed. Opacification of the peripheral lymph vessels reveals two distinct patterns: 1. No, few, or only very small-calibre lymph vessels ("hypoplasia"): 17 patients (primary lymphedema in 14 cases, secondary in 3). 2. Many large-calibre (dilated) lymph vessels ("hyperplasia"): 15 patients (primary lymphedema in 2 cases, secondary in 13). An occasional finding in "hypoplasia" is drainage of the contrast material in the region of the adventitia of vessels, and a network of extremely fine lymph vessels apparently corresponding to the dermal plexus is sometimes observed. Because it leads to the opacification of barely perceptible lymph vessels in the extreme periphery which were previously inaccessible to radiology, indirect lymphography offers a genuine gain in information and improves the differential diagnosis. When administered correctly, Iotasul invariably enhances the peripheral lymph vessels without making any great demands of the patient or investigator.
From the practical point of view following measuring methods offer a valuable help for the assessment of vascular leg problems: 1. Doppler probe. 2. Peripheral venous pressure measurements. 3. Plethysmography. 4. Thermography. Among these methods, a Doppler ultrasonic detector belongs to the basic equipment of every physician dealing with peripheral vascular problems. Severity and localization of arterial occlusions, pelvic vein obstruction and valvular incompetence of superficial and deep leg veins can be verified by this method. The other procedures provide information concerning the severity of a venous insufficiency and the indication and control of therapy. They can also be applied as screening methods for deep vein thrombosis.
A short review concerning definition, clinical relevance and therapy of varicose veins, chronic venous insufficiency and postthrombotic syndrome is given. It is proposed to define chronic venous insufficiency on a morphological base. Stage I is characterized by subfascial congestion, oedema and corona phlebectatica, stage II by induration and stasis dermatitis, stage III by the occurrence of venous ulcers. The postthrombotic syndrome is a special form of chronic venous insufficiency which can be distinguished by the clinical pattern alone.
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Venous pressure measurement has become an important investigation method for the assessment of a venous dysfunction in the lower extremity. It can be performed in every physician's practice with simple equipment. For a graphic documentation a pressure transducer, an electromanometer, and a pen recorder are required. By this method the following clinical questions can be answered: Severity of venous dysfunction, quantitative assessment of the ambulation hypertension; Course of venous dysfunction after thrombosis. In what cases may an improvement be achieved (indication for Palma's operation or of excision of the long saphenous vein and of incompetent perforators, respectively); and Objective control of success after therapy.
A survey of the practical use of plethysmography for phlebological purposes is given. The most important applications for plethysmographic methods are: Screening for deep leg vein thrombosis with satisfactory accuracy in total proximal occlusions; estimation of capillary filtration rate (no clinical value); function of muscle pump, indication and control of therapy; quantitative arterial blood measurement; and determination of systolic blood pressure at the ankle level and in the toes. Today's most perfect method for practical use is strain gauge plethysmography.
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The following effects of a massage by the Lymphapress apparatus could be demonstrated by girth measurements and nuclear medical investigations on the treated extremity: 1. Volume reduction (in lymphedema in average 4,6% of the basic extremity volume after 3 h). 2. Improvement of the lymph kinetics in cases with intact or decreased lymph transport. If isotopic lymphography failed to show any lymphatic transport as in cases with severe, indurated lymphedemas no effect on the lymph kinetics could be demonstrated. 3. Decrease of albumin content in the tissues. However there is an increase of local albumin concentration in lymphedema by overproportional water reduction. Therefore compression bandages should be applied between the Lymphapress massages for maintenance of the effect.
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In a prospective study 169 patients with clinically suspected leg/pelvic-vein thrombosis were tested by 131 I fibrinogen uptake-test and radionuclide venography for confirmation of this diagnosis and also by a nuclearmedical lung investigation. In all cases of an abnormal perfusion scan a supplementary ventilation scan was performed. The perfusion scan has a sensitivity for pulmonary embolism of near 1.0 but its specificity is only 0.57. An additional ventilation study (133 Xenon, 81m Krypton) improves the specificity to 0.95. A mismatch of regional ventilation and perfusion is the nuclearmedical substrate of pulmonary embolism. The diagnosis of thrombosis was confirmed in 105 of 169 cases (62%). Thrombosis was located in the lower legs in 56%, in the thigh veins in 23% and in the external iliac veins in 21%. From 105 patients with leg/pelvic-vein thrombosis 60 (57.1%) had pulmonary emboli, from 64 patients with negative tests concerning thrombosis only 3 (4.7%) (p < 0.001). Pulmonary emboli were present in 46% when thrombosis was located in the lower legs, in 67% when thigh veins and in 77% when pelvic veins were involved. The average frequency of 57% emboli found in patients with leg and pelvic vein thrombosis agrees with data from pathologic-anatomical studies. An analysis of these patients with embolism showed that 70% of them were over 70 years old, that 52% of the emboli originated from thigh and pelvis and 43% from the lower leg and that 59% had no clinical signs of embolism. 80.4% of the patients had multiple perfusion defects (up to 9) which correlated in size with the severity of the clinical symptoms and which were about equally distributed in both lungs. Larger perfusion defects occure more frequently with thromboses of the thigh and pelvis than in thromboses of the lower leg. According to the chest x-ray pulmonary emboli were suspected to only 6 of 26 patients with clinical evidence of embolism (23%).