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Biomedical subjects

H Partsch

Publications and source records attributed to H Partsch.

At least 127 records · Page 7Linked to original sources
PubMed1978

[Influence of dihydroergotamine and leg compression on the blood volume in different regions of the body (author's transl)].

After intravenous injection of 99mTc labelled autologous erythrocytes the radioactivity of a definite body-region is proportional to the local blood volume. By whole body scintigraphy it is possible to assess simultaneous changes of blood volume in different interesting regions. By this method the influence of 1 mg dihydroergotamine i.v. was investigated in 10 patients and of compression of both legs by inflatable leg cuffs (Jobst) with pressures of 25 and 40 mmHg (3,3 and 5,3 kPa) in 7 patients. After dihydroergotamine statistically significant decreases of blood volume were found in the legs and arms and increases in the thorax and liver. Over the abdominal region there was a statistically not significant decrease of blood volume. After leg compression a statistically significant decrease of blood volume in the legs and an increase in thorax, liver and abdomen were found. The arms showed a statistically not significant blood volume increase. The blood volume diminishing effect of dihydroergotamine in the legs was 20,4% in average, of a leg compression (25 mmHg=3,3 kPa) 33,4%. Contrary to the general opinion a reduction of blood volume was also found in legs with severe varicosis. The diminution of blood volume is even more intense in such cases than in normal legs. The results after dihydroergotamine are explained by its well known constrictor effect on the capacitance vessels in the extremities.

Abdomen↗
PubMed1978

[Clinical diagnosis of acute gonorrhic perihepatitis].

At the end of her menstruation a 25 years old woman develops acute pain in her right lower and upper abdomen radiating into the right shoulder. There are pains during breathing, coughing, and changing of position, vomitus, and local signs of peritonitis in the right lower and upper abdomen, subicterus and leucocytosis. Gonococci in the cervical smear are demonstrated by Grams stain and by culture. Two days after treatment with 3,5 millions IU of penicillin G sodium and 500.000 IU procaine penicillin per day the complaints disappeared. The demonstrated signs and symptoms are characteristic for acute perihepatitis gonorrhoica which seems to occur more often as a complication of gonococcal adnexitis than is suspected. The symptoms are so typical that the diagnosis can be made also without confirmation by laparascopy.

Adult↗
PubMed1977

[Functional indications for stripping in the treatment of varicose veins (author's transl)].

The venous pressure was measured in a dorsal foot vein with the aid of a Statham transducer and the foot volume was simultaneously registered by a water plethysmograph in 37 legs of patients with varicosis of the internal saphenous vein. 17 legs showed signs of chronic venous insufficiency of post-thrombotic syndrome. These measurements were carried out in the standing position and during standardized knee-bending exercises. They were repeated after elimination of the varicose veins by a tourniquet on the distal thigh and lower leg and between 2 and 6 weeks after a stripping operation. There was a statistically significant correlation between the functional improvement after elimination of the varicose veins by tourniquet and by operation. It is concluded that the elimination of varicose veins by compression allows a reliable prognosis of the functional gain obtained by the operation (accuracy of the prognosis for the pressure measurements: 95%, for volume measurements: 80%). The results were compared with the values in a healthy control group (n = 17), a non-operated group of patients with chronic venous insufficiency (n = 30) and a group of patients with post-thrombotic syndrome (n = 30). The investigation of the function of the calf-muscle pump and the amelioration obtained by compression of varicose veins is a helpful guide in the decision whether to operate or not on patients with chronic venous insufficiency or with post-thrombotic syndrome. A significant functional gain can be sometimes obtained in such patients after stripping, whilst in other cases, which cannot be differentiated on a merely clinical basis, bad results are reported. The described functional investigations allow a better differentiation of these alternatives than phlebography and are, therefore, recommended as routine methods in such cases.

Adolescent↗
PubMed1977

[The influence of dopamine on the regional blood volume in liver, abdomen, chest and extremities (author's transl)].

The influence was studied of 3 and 6 gamma/kg/min. dopamine on the blood volume in the liver, abdomen, chest, arms and legs in ten volunteers with healthy livers, and a comparison was made between the effect of dopamine and the blood volume changes caused in these body regions by inflatable whole-leg boots at a pressure of 40 mm Hg. Regional blood volumes and any induced changes were studied by means of 99 m Tc labelled autologous erythrocytes. A gamma camera with a pinhole collimator and a small computer was used, the field of vision of the camera being 148 cm in diameter. Changes in regional activity reflect changes in the regional blood volume. 1. Whole-leg compression at 40 mm Hg led to an increase in the blood volume of the liver, abdomen and chest, but to a reduction in the legs, while no significant change was observed in the arm blood volume. 2. On infusion of 3 gamma/kg/min. dopamine for 15 minutes no significant change occurred in the blood volume of the liver and abdomen. The chest blood volume increased, while the blood volume of the upper and the lower extremities showed a statistically significant decrease. 3. On infusion of 6 gamma/kg/min. dopamine for 10 minutes no significant change occurred in the blood volume of the liver, while the chest blood volume continued to rise and that of the upper and lower limbs continued to fall. 4. Ten minutes after the end of the infusion there was no significant change in liver and abdominal blood volume as compared with the last value measured during infusion of 6 gamma/kg/min. dopamine. By that time the chest blood volume had already fallen and the blood volume of the arms and legs increased. The possible action mechanisms via dopamine-specific and other catecholamine receptors are discussed in this paper.

Abdomen↗
PubMed1977

[Antithrombin III deficiency and tendency to thrombosis (author's transl)].

Antithrombin III (AT III) was determined in 290 patients with deep venous thrombosis and/or pulmonary embolism by immunological methods (radial immunodiffusion, Laurell technique) and by biological activity (heparin cofactor activity and anti-Xa activity). Patients with venous thrombosis had a significantly lower AT III concentration, as determined by the immunological methods or biological method (heparin cofactor activity), than normal persons without any history of venous thrombosis. A decreased level of AT III was found in 27 patients. In these patients the immunoreactive antithrombin III was decreased to the same degree as biological activity (heparin cofactor activity or anti-Xa activity). Thirteen out of these 27 patients belonged to 9 families and, hence, congenital AT III deficiency can be assumed in these cases. The aetiology was unknown in the other half. Patients with AT III deficiency are prone to spontaneous and/or recurrent venous thrombosis. A high incidence of pulmonary embolism and particularly, of fatal pulmonary embolism is remarkable. In more than half of the patients the first thrombotic event occurred before the age of 35. The treatment of choice in such patients is with oral anticoagulants of the coumarin group.

Adult↗
PubMed1976

[Malabsorption and vitamin B1 deficiency in familial acrodystrophic neuropathies (author's transl)].

9 members of 4 families with familial acrodystrophic neuropathies were investigated. Lowered levels of vitamin B1 (thiamine pyrophosphate) were found in all cases except one. In this patient, as in 10 healthy control persons, normal values were obtained. The D-xylose test, which was carried out in 4 patients from 3 families, revealed intestinal malabsorption in all cases. It is suggested that malabsorption and deficiency of vitamin B1 as demonstrated in this report play a role in the development of these familial disorders.

Adult↗
PubMed1976

[Detection of venous occlusions of the leg and pelvis by means of nuclear medicine].

Based upon experience with 563 patients, the 131 I fibrinogen test has proven a reliable method for the diagnosis of acute leg vein thrombosis. Investigations correlated by means of roentgenological phlebography performed by routine technique in 83 patients showed similar results in 77% of the cases. Analyzing the negative results of 23%, we consider 19% of the discrepancies to be due to faulty phlebographic and 4% to faulty fibrinogen results. Phlebography may reveal false positive results in recurrent thromboses and false negative results in thrombosis of the lower legs. The fibrinogen test may reveal false positive results after trauma, fractures, and in cases of superficial phlebitis and arthritis. Pelvic venous occlusions are detectable by radionuclid venography. This method is non-invasive (injection of 99m Tc albumin particels or microspheres in less than 1 ml, by means of a very thin needle into a dorsal foot vein). A lung scan is obtained in every examination. The results conformed in 89% of 250 patients with those obtained from Doppler ultrasonic investigations. Two thirds of all pelvic vein thromboses were located on the left side. Perfusion defects of the lungs were probably caused by pulmonary embolism (lung scanning) and were found in an average of 54% of all leg and pelvic vein thromboses (in thrombosis of the lower legs in 35%, of the thigh in 57% and of the pelvic vein in 70%). These figures are in good conformity with pathological-anatomical data concerning the frequency of pulmonary emboli and infarctions in leg and pelvic vein thrombosis.

Adult↗
PubMed1976

[Compression treatment in venous and lymphatic flow disorders of the leg].

Based on our investigations, the mode of action of compression bandages is discussed ant the physiological and physical principles of this therapy are reviewed. The different basic forms of compression therapy, for example, non-elastic bandages, elastic bandages, use of foam rubber and sponge rubber inserts as well as compression stockings, are mentioned. The side effectes of compression therapy are treated and the indications for compression therapy in superficial and deep thromboses, postthrombotic syndrome and lymphedema are discussed.

Bandages↗