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Biomedical subjects

H Partsch

Publications and source records attributed to H Partsch.

At least 91 records · Page 5Linked to original sources
PubMed1987

[Angiodysplasias of the extremities].

The term "angiodysplasia" is defined and a historical review of vascular malformation given, particularly the Klippel-Trenaunay, F.P. Weber, and Servelle-Martorell syndromes. The casual, uncritical use of these terms in the past, especially the combination of these entities into one syndrome, has resulted in considerable confusion. Current classifications are based on nosologic, pathophysiologic, anatomical, clinical, and didactic criteria. Modern diagnostic methods and the results of surgical corrections of vascular malformations have led to a better understanding of the underlying pathomechanisms and have offered new prognostic and therapeutic aspects.

Arm↗
PubMed1986

[Regional hypoplasia of dermal lymphatic vessels--a new variant of congenital lymphedema].

The value of new investigative methods of the most peripheral lymphatics of the skin (fluorescence microlymphography, indirect lymphography) is demonstrated by the case report of an 18 year-old girl. Regional hypoplasia of dermal lymphatics was detected in the lymphoedematous proximal and middle phalanges of the fingers while the initial lymphatics of the normal-appearing distal phalanges showed no obvious change. The subcutaneous lymph-collectors were ectatic and increased in the oedematous parts as well as in the normal-looking ends of the fingers. Hence, this is a new variant of lymphoedema, which is not caused by hypoplasia of lymph-collectors, but by a regional lack of initial lymphatics of the skin.

Adolescent↗
PubMed1986

Lymphomatoid papulosis: remission following intravenously administered acyclovir.

In a 54-year-old male patient suffering from Hodgkin's disease, lymphomatoid papulosis occurred. Complete clearing of the skin lesions was observed immediately after intravenously administered acyclovir. The patient had numerous relapses of his skin eruption with complete responses after each course of intravenously applied acyclovir. This striking therapeutic effect parallels reports of regression of mycosis fungoides and chronic generalized lymphadenopathy after acyclovir application. The mode of action of acyclovir in these disorders is not known. They all are characterized by involvement of the T cell system, and in all these diseases, a virus etiology has been proved or is suggested. Thus, a specific effect of acyclovir on T lymphocytes or selectively on helper T cells is discussed. Alternatively, the virustatic effect of acyclovir could be responsible for the therapeutic success.

Acyclovir↗
PubMed1985

[Pathogenesis of the venous leg ulcer].

Based on different experimental findings, the following sequence of pathogenetically important factors for the development of venous ulcers is outlined: Valvular incompetence, reflux----chronic venous ambulatory hypertension----capillary dilatation and deformation----hyperemia----increased transendothelial passage (protein), microlymphangiopathy----protein deposition in the tissue. Deficient fibrinolysis----pericapillary fibrin cuffs----diffusion block----local hypoxia, tissue death. Although other mechanisms and complex factors may also play important additional roles, for the first time a reasonable explanation can be offered for the development of venous ulcers that is in agreement with all consistent findings.

Capillaries↗
PubMed1985

[Supplementary instrumental examinations in the most frequently occurring peripheral vascular diseases in general practice].

Noninvasive investigative methods are valuable for the practical diagnosis of several peripheral vascular disorders. Doppler ultrasound is very useful for the detection of incompetent saphenous and perforating veins and for the measurement of systolic ankle pressure, which today is the best screening method for arterial stenoses or occlusions. Acral oscillography, photoplethysmography and thermography, combined with vasodilator (nitroglycerin) or vasoconstrictor (cold) stress tests, may disclose small vessel disease and vasospastic disorders (Raynaud phenomenon). To answer the question of whether varicosities should be eliminated by surgery or sclerotherapy in patients with severe stages of chronic venous insufficiency (e.g. crural ulcers), investigations of the venous pump by venous pressure measurement or (photo-)plethysmography with and without digital occlusion of the suspected leakage points are recommended. Doppler probe, plethysmography and thermography are valuable screening methods for deep vein thrombosis and help to restrict phlebography to patients on whom fibrinolysis or thrombectomy is carried out. For the majority of patients undergoing conservative treatment, these noninvasive diagnostic procedures are usually sufficient.

Arterial Occlusive Diseases↗
PubMed1984

[New aspects in the diagnosis of venous and lymphatic diseases of the legs].

A survey on new methods for the detection of deep vein thromboses and for the investigation of lymphedemas of the lower extremities is given. Doppler-ultrasound, plethysmography and tele-thermography are valuable screening procedures for the detection of a deep vein thrombosis. Nuclear medical methods such as 131 J fibrinogen or 99-m-TC-plasmin-uptake test as well as isotopic phlebography are additional non-invasive procedures. For the routine diagnosis of lymphedema, isotopic lymphography can be recommended. Recently described methods such as quantitative isotopic lymphography and indirect lymphography with the new contrast medium Iotasul will probably enhance our present knowledge concerning pathophysiology and therapeutical effects in lymphedemas.

Adolescent↗
PubMed1984

The dermal lymphatics in lymphoedema visualized by indirect lymphography.

Iotasul, a new water-soluble contrast medium, is very suitable for subepidermal infusion (indirect lymphography) for the demonstration of small (initial) dermal lymphatics in the macro-range (precollectors). By this method normal lymph vessels can be demonstrated in the healthy skin of hands and feet which are so fine that they cannot be punctured for direct lymphography. We studied thirty-eight patients with various forms of lymphoedema by indirect lymphography. In patients with congenital lymphoedema (particularly Milroy's disease) the initial dermal lymphatics in the lymphoedematous region were absent but large lymph collectors were present. Hyperplasia of dermal lymphatics in the form of an extremely fine net was seen in most patients with lymphoedema praecox and tardum. In some forms of primary lymphoedema the defect may be in the initial dermal lymphatics. In secondary lymphoedema, the changes in the peripheral lymphatics (mainly distension and congestion) are apparently a consequence of the primary lesion in the lymph nodes and large collectors. Indirect lymphography might be useful for the early diagnosis of mild lymphoedema and for excluding patients with hypoplasia of initial lymph vessels from surgery.

Adolescent↗