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Biomedical subjects

H Oshima

Publications and source records attributed to H Oshima.

At least 307 records · Page 17Linked to original sources
PubMed1983

[Testicular functions in pubescent and adult patients with cryptorchidism--comparison between descended and undescended sides].

Ten pubescent or adult patients with unilateral cryptorchidism were examined for abnormal findings of the epididymis and of the gabernaculum Hunteri in the undescended sides at orchidopexy. Histological examinations and the experiments for enzyme activities relating to androgen biosynthesis in vitro were also performed using biopsied specimen obtained from both sides at the operation and the results for the descended and the undescended sides were compared. The results are as follows. The undescended sides were accompanied by either morphological abnormalities of epididymis or shortening of the testicular blood vessel. Ectopy of the gaberunaculum was observed in the undescended side. Both Johnsen's mean score and enzyme activities relating to androgen biosynthesis in the undescended sides were lowered compared to those of the descended sides. One case showed an elevated FSH level in the blood associated with a low Johnsen's score in the descended side and in other case the LH level in the blood was elevated. These results indicate that not only the spermatogenesis but androgen biosynthesis in the undersended sides are lowered compared to the descended sides. The results, moreover, suggest the possibility of the involvement of congenital testicular disorder even in the descended side of the cryptorchidism.

3-Hydroxysteroid Dehydrogenases↗
PubMed1983

Induction of polymorphonuclear leukocyte-mediated cytolysis by wheat germ agglutinin and antitumor antibody.

The role of polymorphonuclear leukocytes (PMNs) as effector cells in tumor lysis was investigated in vitro. PMNs were obtained from the peritoneal cavity of C3H/He Mice injected ip with 2 ml of 12% casein sodium. These PMNs could lyse murine MM46 tumor cells in the presence of the plant lectin, wheat germ agglutinin (lectin-dependent PMN-mediated cytolysis). PMNs alone did not cause cytolysis. PMNs obtained 6 hr after casein injection were effective against tumor target cells but those obtained 3 hr after the injection were not. Other lectins, such as concanavalin A, phytohemagglutinin, pokeweed mitogen, soybean agglutinin, Ulex europaeus agglutinin, Lens culinaris hemagglutinin and Bauhinia purpurea agglutinin, did not cooperate with PMNs in tumor lysis. Antitumor antibody was another mediator that induced tumor lysis in cooperation with PMNs (antibody-dependent PMN-mediated cytolysis). These results indicate that PMNs can lyse tumor cells in the presence of appropriate mediators.

Animals↗
PubMed1982

[A measurement of 5-androstene-3 beta, 17 beta-diol in human serum (author's transl)].

A radioimmunoassay using specific antisera against 5-androstene-3 beta, 17 beta-diol-11 alpha-succinoyloxy-BSA was developed, and serum concentrations of 5-androstene-3 beta, 17 beta-diol (AD) in normal men and women (maternal vein during pregnancy and cord blood at delivery) were measured. The reliability of the method was assessed by means of the recovery rate (97-109%) and the co-efficient of variation of inter- and intra assay (10-14%). The concentrations in serum samples obtained from various sources were as follows (ng/ml of free steroid mean +/- SD): spermatic vein, 48.57 +/- 50.64, peripheral vein in men aged 57-84, 1.24 +/- 0.47; ovarian vein during follicular phase, 3.81 +/- 3.27, peripheral vein, 1.03 +/- 0.44; maternal vein at delivery, 3.03 +/- 0.77, umbilical artery, 6.58 +/- 3.00, umbilical vein, 6.32 +/- 2.82. Plasma AD levels in the spermatic and ovarian vein were significantly higher than in the peripheral vein, suggesting the gonadal secretion of this steroid. Maternal serum AD concentration increased as pregnancy advanced, and AD levels in cord blood at delivery were significantly higher than that in maternal blood. These results also indicate that AD is one of the products of the feto-placental unit.

Adult↗
PubMed1982

Studies of the human testis. XVI. Evaluation of multiple indexes of testicular function in relation to advanced age, idiopathic oligospermia, or varicocele.

Testicular function was evaluated by morphologic and biochemical methods in 11 infertile men with idiopathic oligospermia, 12 men with varicocele, and 14 elderly men. The results indicate the presence of two separate subgroups with idiopathic oligospermia with distinct endocrine and morphologic parameters and suggest the involvement of different pathogenetic factors for testicular disorders among these four groups. Biochemical indexes provide further confirmation of the validity of the Leydig cell cluster index (number of Leydig cell clusters per tubular section) as a useful evaluation guide. The results support the importance of combined studies of circulating hormones and testicular histologic features in providing insight into spermatogenic disorders. Recognition of etiologic diversity is an essential basis for further efforts to delineate and apply current or new hormonal techniques for therapy.

Adult↗
PubMed1982

Studies of the human testis. XVII. Gonadotropin regulation of intratesticular testosterone and estradiol in infertile men.

Serum levels of LH and FSH and the intratesticular concentrations of testosterone (T) and estradiol (E) were measured in biopsy tissue from 40 infertile men, aged 21-36 yr, of whom 21 were oligospermic men with varicocele and 19 were men with idiopathic oligospermia. Intratesticular T and E concentrations were negatively correlated (P less than 0.001) with testicular volumes, as measured with a calibrated orchidometer, suggesting that differences in measured intratesticular steroid levels in part reflect altered relative Leydig cell density as seminiferous tubular volume changes. To gather information about the regulation of intratesticular T and E by gonadotropins, we calculated an index of intratesticular steroid content by multiplying steroid concentration by testicular volume and compared these values with circulating LH and FSH levels. Highly significant positive correlations were found between both serum LH and FSH and intratesticular E content and between LH and FSH and intratesticular T content. Multivariant stepwise regression analysis revealed that while serum FSH is a strong predictor of intratesticular E (r = 0.72; P less than 0.001), serum LH is not (partial r = 0.00 when controlling for the influence of FSH). Instead, the apparent relationship between Serum LH and intratesticular E results from the highly positive correlation between serum LH and FSH in the patients studied (r = 0.71; P less than 0.001). Similarly, circulating LH levels are independently related to intratesticular T content (r = 0.67; P less than 0.001), whereas the relationship between FSH and T is indirect (partial r = 0.06 when controlling for the influence of LH). We believe that these associations suggest that the major regulator of intratesticular T content is LH and that FSH may be the important gonadotropin regulating intratesticular E.

Adult↗
PubMed1980

The male factor.

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Antibodies↗