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Biomedical subjects

H Mizoguchi

Publications and source records attributed to H Mizoguchi.

At least 451 records · Page 25Linked to original sources
PubMed1981

Suppression of in vitro granulocyte-macrophage colony formation by the peripheral mononuclear phagocytic cells of patients with idiopathic aplastic anaemia.

To investigate whether phagocytic cells play a role in the pathogenesis of aplastic anaemia, we studied the effect of the mononuclear phagocytic cells in the peripheral blood from patients with idiopathic aplastic anaemia on granulocyte-macrophage colony (GM-colony) formation. There was no apparent infection in the studied patients. In nine out of 20 cases the mononuclear cells suppressed the formation of GM-colonies by normal bone marrow. Removal of the phagocytic cells by carbonyl iron powder caused a loss of this suppressive effect. These results suggest the requirement for phagocytic cells in this suppressive effect and the possible involvement of phagocyte-mediated immunological mechanism in the pathogenesis of some cases of idiopathic aplastic anaemia.

Adult↗
PubMed1981

Fertilizability of ova from young or old hamsters after spontaneous or induced ovulation.

Young or aged hamsters, subjected to spontaneous or induced ovulation, were examined for ovulation rate, fertilization rate, and chromosomal normality. The fertilization rate in aged animals was decreased but there were no differences in ovulation rate. Abnormal chromosomes and degenerated oocytes occurred in the aged animals after induced ovulation. The fertilizing ability of sperm incubated in the uteri of young or aging animals showed no obvious differences when used for in vitro fertilization. These results indicated that defective ova represent one of the major factors leading to increased preimplantation loss in aged animals and also that superovulation of aged animals results in no beneficial effect, over spontaneous ovulation, on the fertilization process.

Age Factors↗
PubMed1980

Erythroid precursor cells in primary acquired and secondary sideroblastic anemia.

In order to study the changes in erythroid precursor cells in primary acquired and secondary sideroblastic anemia, bone marrow cells from 4 patients with primary acquired sideroblastic anemia (PASA) and 3 patients with refractory anemia with excess of myeloblasts (RAEM) or erythroleukemia associated with an excess of ringed sideroblasts were cultured for erythroid colony-forming units (CFU-E). The number of CFU-E was markedly decreased in all 7 cases, and erythroid colonies formed consisted exclusively of normal-appearing erythroblasts, while ringed sideroblasts were observed in scattered single erythroblasts or in small aggregates of erythroblasts in primary as well as in secondary sideroblastic anemia. These findings may indicate the presence of 2 populations of erythroid progenitor cells in the bone marrow of patients with primary acquired and secondary sideroblastic anemia. A slight to moderate decrease in granulocyte-macrophage colony-forming units (GM-CFU) was observed in 3 cases of PASA. The decrease in GM-CFU, however, was marked in sideroblastic anemia associated with RAEM or erythroleukemia.

Aged↗
PubMed1980

Enhancement of granulocytic colony formation of deletion of phagocytic cells in the bone marrow patients with idiopathic aplastic anemia.

To study the pathogenesis of aplastic anemia, phagocytic cells from the bone marrow of patients with aplastic anemia were investigated. From 10 of 10 patients with this disease the concentration of CFUc in the bone marrow cells significantly increased after the removal of phagocytic cells. On the other hand, in bone marrow from only 4 of 27 controls, 22 non-aplastic anemia patients and 5 normal volunteers, the concentration of CFUc increased after the same treatment. From these findings, it may be inferred that phagocytic cells from the bone marrow of patients with aplastic anemia suppress proliferation and differentiation of granulocytic progenitor cells, and that this phenomenon is related to the development of this disease.

Adolescent↗