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Biomedical subjects

H Martin

Publications and source records attributed to H Martin.

At least 397 records · Page 22Linked to original sources
PubMed1976

Isolation and genetic analysis of mutant strains of Chlamydomonas reinhardi defective in gametic differentiation.

Impotent mutant strains of Chlamydomonas reinhardi, mating-type (mt) plus, are described that have normal growth and motility but fail to differentiate into normal gametes. Procedures for their isolation and their genetic analysis are described. Five of the imp strains (imp-2, imp-5, imp-l, imp-7, and imp-8) exhibit no flagellar agglutination when mixed with mt- or mt+ gametes and the mutations are shown to be unlinked to the mt locus (with the possible exception of imp-7). Two of the strains (imp-3 and imp-4) carry leaky mutations that affect cell fusion; neither mutation is found by tetrad analysis to be linked to mt or to the other. Cells of the imp-1 strain agglutinate well with mt- gametes and active agglutination continues for up to 48 hours, but cell fusion occurs only very rarely. Analysis of these rare zygotes indicates that imp-1 is closely linked to the mt+ locus, and fine-structural studies reveal that imp-1 gametes produce a mutant mating structure involved in zygotic cell fusion. The development of sexuality in C. reinhardi therefore appears amenable to genetic dissection.

Acetates↗
PubMed1976

[Malignant stem-cell tumor of the pineal region with unusual differentiation (author's transl)].

Report on a boy aged 10 with a malignant mixed stem-cell tumor of the pineal region. The tumor consists of an adult teratoma, circuscribed teratocarcinoma, endodermal sinus-tumor-like, choriocarcinomatous and germinoma (pinealoma) tous parts. The various parts of this tumor demonstrate the multipotentiality of stem-cells. Stem-cells produce similarly composed tumors also in other region.

Autopsy↗
PubMed1976

[Adrenoleukodystrophy. Clinical-pathologic case history and literature review].

This article presents the clinical and pathological history of a 10-year-old boy with adrenoleukodystrophy as well as a tabular survey of 17 additional cases of which the necropsy records were published in the literature. So far as the case of adrenoleukodystrophy directly observed by the authors themselves is concerned, commencement of the disease was in the seventh year of life, with symptoms of Addison's disease and diffuse inflammatory cerebral sclerosis being observed at about the same time. The cerebral disease manifested itself as a progressive pseudobulbar and pyramidal tract symptomatology and as a progressive cerebral psychosyndrome reminiscent of an endocrinal psychosyndrome. Morphologically, the adrenoleukodystrophy was characterized by severe dystrophy of the cortex of the suprarenal gland and the brain are considered the points of action of a still unknown noxa.e suprarenal gland as well as by extensive sudanophilic processes of decomposition in the cerebromedullary substance, putamen, pallidum, and thalamus. Striated cells and cytoplasmic filamentous inclusions observed in the brain and suprarenal glands in a number of cases reported in the literature were not found by the present authors. The cortex of th

Addison Disease↗
PubMed1976

[About a rare teratoma of the pineal region (author's transl)].

1. Report on a man aged 33 with a rare teratoma of the pineal region (adult teratoma with pinealoma-like parts) and 8 related cases of the literature. 2. The absence of the pinealis in our case and in 4 related cases of the literature is explained as a result of destruction of pinealis by the tumor. 3. The pinealis in our case cannot be considered as the origin of pinealoma-like part of the teratoma. The pinealoma-like part seems to have the same root as the teratoma. The argumentation of this opinion is the arrangement and the seize of pinealoma-like parts in the teratoma as well as the often shown proof of an unchanged pinealis and the observation of similar histological patterns in extracranial teratomas.

Adult↗