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Biomedical subjects

H Lindemann

Publications and source records attributed to H Lindemann.

At least 55 records · Page 3Linked to original sources
PubMed1990

Autogenic drainage: efficacy of a simplified method.

A simplified and modified technique of the original autogenic drainage (AD) is described which is supplemented by breathing against an external flow resistance. The new method allows a better teaching and learning. It's efficacy is proven by means of a comparative trial of AD and PEP physiotherapy (i.e. expiration against a defined stenosis). The autogenic drainage (AD) was introduced by a Belgian working group (2). The basic idea was to support the elimination of mucus by deep breathing and by repressing the cough as long as possible. However, a rather sophisticated method impeded teaching and learning of AD (1). Thus, till now, there are only preliminary results which suggest the efficacy of AD (e.g. 3). Therefore, a simplified technique was developed and examined with regard to its sputum eliminating effect.

Adolescent↗
PubMed1990

[Inhalation treatment of obstructive bronchitis in infants and young children with bronchodilator agents].

In 100 infants and young children with obstructive bronchitis, pulmonary function investigations were carried out following prior inhalation of 1. ipratropium bromide, 2. fenoterol, 3. fenoterol after a prior single administration of predisone, 4. adrenaline, 5. isotonic saline solution. The results show that bronchodilation may be expected in approximately 22% of the cases. As a result of vasoconstriction, a dilatation of the airways can be achieved in roughly 35% of the patients.

Administration, Inhalation↗
PubMed1990

[Elimination of secretions in CF patients under amiloride inhalation].

Inhaled amiloride reduces active absorption of sodium of respiratory epithelium in CF patients and so, transiently, diminishes loss of water. 10 CF patients, 8 to 28 years of age, were examined on two days. First day, they inhaled in a randomised order isotonic saline and a solution of amiloride hydrochloride (0.3 mg/ml) one after another, each inhalation taking twenty minutes. Second day, inhalations were performed in an inverse order. To intensify the effect of inhalation, the inhalation procedure was combined with "autogenic drainage", a special kind of physiotherapy. Main criterion for evaluation was the amount of expectorated sputum. Mean increase of sputum during amiloride inhalation in comparison to saline was +50.4%. Patients and physiotherapist observed a liquefaction of secretion and a decrease of coughing by amiloride and a support of physiotherapy. These results suggest a beneficial clinical effect of regular amiloride inhalation in CF patients.

Absorption↗
PubMed1990

[The effects of bronchodilating substances in acute obstructive bronchitis in early childhood].

In 120 infants and young children with wheezy bronchitis, pulmonary function examinations were carried out prior to and following inhalation of 1. ipratropium bromide, 2. fenoterol, 3. fenoterol after a prior single administration of prednisone, 4. adrenaline, 5. theophylline administered via a gastric tube, 6. isotonic saline solution. The results show that bronchodilator drugs may be effective in approximately 27% of the patients.

Asthma↗
PubMed1989

[Angiotensin converting enzyme (ACE) in the follow-up control of children and adolescents with allergic alveolitis].

We studied the concentration of angiotensin-converting enzyme (ACE) in 80 respiratory and hepatologic healthy patients aged 4 months to 35 years. The normal values ranged from 9.4-38.8 U/ml with a tendency of lower ACE-concentrations in the older patients. In the follow up of 16 patients with hypersensitivity pneumonitis a decrease of initially elevated values of ACE was observed in 12 cases. In two patients with a recurrent course of hypersensitivity pneumonitis ACE rose to levels above 30 U/ml. These findings suggest that ACE-concentration in serum is an additional parameter to evaluate the acute stage of disease in patients with hypersensitivity pneumonitis.

Adolescent↗
PubMed1989

[Pneumonia in childhood: peculiarities in diagnosis and therapy].

Pneumonia in childhood is associated with a number of peculiar features with respect to the pathogens, the course of the disease, and its radiological appearance. The maturation of the immune system also plays a major role. Special diagnostic features involve the - sometimes discrete - clinical signs, problems with the collection of sputum, the technique employed for obtaining x-ray films of the chest, and the procedure for broncho-alveolar lavage. Only rarely is it possible to clarify the aetiology in good time. For this reason, an initial course of antibiotic treatment targeted to the probable pathogens involved, makes good sense. In accordance with the subsequent identification of the organisms responsible (successful in about 50 per cent of the cases), and the antibiogram established, the form of treatment is subsequently modified.

Anti-Bacterial Agents↗
PubMed1989

[Oscillo-resistometry in bicycle ergometry stress].

With the aid of a Siregnost FD 5, modified with a reference resistance of 2 kPa/l/s, measurements of the oscillatory airway resistance were carried out in 16 healthy subjects and 22 patients with asthma aged between 7 and 22 years, during and after physical exercise. As a consequence of increasing turbulent flow, in the case of the patients with healthy airways, a significant increase in the airway resistance (RmOS) occurred under conditions of physical exercise, which was due to the most part to an increase in the phase angle. Initial measurements with the custo vit suggest that the used reference resistance in the FD 5 is responsible for this. In the case of asthmatic patients, the average increase in RmOS was more marked. However, two groups of patients were differentiable: in the first group, under conditions of exercise, a decrease in the initially slightly elevated airway resistance occurred, while in the other patient group the airway resistance remained unchanged at a high level, even after exercise. In two patients, marked obstruction occurred on conclusion of the exercise examination. In one of the subjects with supposedly healthy airways, a bronchospasm developed during physical exercise and made it necessary to abandon the examination. Thus, there can be no doubt as to the clinical relevance of such measurements during and after physical exercise.

Adolescent↗
PubMed1987

[Mucoviscidosis and precapillary pulmonary hypertension].

Various pathomechanisms are responsible for the development of pulmonary arterial hypertension (PAH) in cystic fibrosis (CF). Main factors are chronic hypoxia and the loss of peripheral vessels caused by recurrent infectious lung disease and lung fibrosis. Measurement of pulmonary artery pressure and pulmonary resistance provide reliable information on PAH. Many non invasive procedures, including echocardiography, myocardial and pulmonary imaging by radionuclide, proved to be not sensitive enough to diagnose PAH. Arterialized pO2 (taken from the hyperemized ear lobe), however, measured during standardized submaximum work load, seems to be a valuable parameter to estimate PAH (r = 0.92). Treatment of PAH in CF-patients is, at the moment, predominantly based on the improvement of the general therapeutical regimen of CF and on long-term oxygen insufflation, which should be initiated as soon as there are first signs of PAH.

Child↗
PubMed1985

Application of restriction endonucleases as a tool for studying the action of 4-S-ethanolsulfido-cyclophosphamide on DNA with known sequences.

Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle changes in DNA structure due to CPA-P1 interaction. In the case of pBR 322-DNA the CPA-P1 treatment of supercoiled circular DNA was more inhibitory to subsequent digestion as compared to the treatment of linearized plasmid DNA molecules.

Bacteriophage lambda↗
PubMed1985

[Monitoring long-term therapy with theophylline preparations in children with asthma].

In 78 children (4 to 17 years of age) with moderate or severe asthma who were additionally treated with sustained-release theophylline preparations, different ways of drug monitoring were examined. Analysis of plasma and saliva theophylline was performed by means of high performance liquid chromatography. Saliva theophylline turned out to permit a reliable prediction of plasma theophylline, if an individual regression is calculated for each patient, basing on 3 simultaneously performed measurements of theophylline levels in saliva and plasma within the therapeutic range of 8 to 20 mg/l. In 25 patients theophylline levels were determined in venous and capillary blood. There was an excellent agreement (r = 0.97). Thus, a convenient monitoring of theophylline treatment in children is possible.

Adolescent↗
PubMed1984

[Body plethysmography in infants and small children. Respiratory function diagnosis using a special baby plethysmograph].

Successful body plethysmographic examination of infants and toddlers can now be performed by means of a special baby plethysmograph which is commercially available (Fa. Jaeger, Würzburg, Fed. Rep. of Germany). The apparatus is equipped with a heated rebreathing system and manipulation ports. Examinations require paying attention to certain potential sources of error: the consequences of necessary sedation; possible undefined leaks due to non-airtight manipulation ports; the influence of irregular breathing or increasing hyperventilation; the effect of nasal resistance; the large variation in total airway resistance; problems in the quantitative evaluation of box pressure/flow curves and curve form analysis. Careful handling can overcome all these difficulties. From the clinical point of view, body plethysmographic examination is just as important for infants and toddlers as for schoolchildren and adults.

Airway Resistance↗
PubMed1982

[Bicycle ergometric examinations and pulmonary function analyses after patch aortoplasty of coarctation of the aorta in children (author's transl)].

The blood pressure of patients who underwent surgical correction of coarctation of the aorta are usually controlled at rest in the upper and lower extremities. The assessment of the success of the operation is then based on these blood-pressure readings. It is, however, more important to control the blood pressure during standardized exercise so that assessment of the capacity for work in daily life could be made. This is best realized with the bicycle ergometric examination with simultaneous blood-pressure readings 40 patients who had undergone surgical correction of the coarctation of the aorta, using the Vossschulte indirect patch aortoplasty method, were examined. The examination results were compared with those of 35 healthy children. The bicycle-ergometric exercise was carried out in stepwise increasing loads of up to 2 Watt/kg body weight. The blood-pressure, were compared based on the age of the patient at the time of the operation, in relation to the time between the operation and the ergometric examination and the age of the patient at the time of the operation. The W170 (Physical working capacity at a heart rate of 170) and the maximum oxygen intake of the subjects were also used as parameters for comparison. It could be seen that the initial blood pressure at rest was, on the average, relatively higher than those of the control subjects. This tendency was also observed during the bicycle-ergometric examination. In some subjects, the blood pressure rose to dangerously high values particularly at 2 Watt/kg body weight. The blood pressures of the patients remained on the average higher than those of the control subjects during the resting phase after the exercise (control after 1' and 5') and normalized relatively slowly. 45% of the patients showed pathological blood-pressure values. The W170 of the patients, a parameter for precise assessment of the cardiorespiratory fitness, was measured. The findings in the patients showed only very slight difference compared to those of normal subjects in all the assessment parameters. This applies also to the maximum oxygen supply, particularly when one considers the standard deviation. It is advisable to consider limitation of activities, for example sport, in the special cases where there are dangerously high blood-pressure rises during exercise even though no subjective complaints are made by the patients and the blood pressures at rest are normal. It is, on the whole, interesting to note that the operated patients compare very favourably with the control subjects in the W170 and the maximum oxygen-intake values.

Adolescent↗