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Biomedical subjects

H Koch

Publications and source records attributed to H Koch.

At least 415 records · Page 23Linked to original sources
PubMed1976

[Culture media for Salmonella dublin on a chemically defined basis].

The nutrient demand of S-dublin strains was investigated. Media on chemically defined basis for culturing of S. dublin are recommended with reference to the above studies. The definition includes Na2HPO4, KH2PO4, NaCl, glucose, the amino acids L-asparaginic acid, L-cystine, L-glutamic acid, serine, and L-threonine, and nicotinamide as vitamin component. Such media will be quite favourable for certain culturing problems, but complex substrate (yeast extract, peptone, tryptone) should be added for high yields.

Culture Media↗
PubMed1975

[The significance of endoscopic retrograde cholangiography (ERC) in biliary stasis and the postcholecystectomy syndrome (author's transl)].

In a group of 103 patients with biliary tract disease only 27% had findings of ERC which were concordant with the operative observations. False-negative results were present in 20%, while in 55% conventional cholangiography did not provide enough opacification for exact diagnosis. The size of the common bile-duct lumen correlated with the degree of biliary stasis. It can, therefore, be used as a good diagnostic indicator. The normal lumen diameter as measured by ERC was 6.29 +/- 1.29 mm in the suprapancreatic part of the common bile-duct. All cholecystectomised patients had a dilated lumen, the borderline value for biliary stasis being at 13-14 mm.

Bile Duct Neoplasms↗
PubMed1975

[The effect of caerulein on gastric mucosal blood-flow and gastric secretion (author's transl)].

The effect of Caerulein, a decapeptide produced from the skin of the Australian frog Hyla caerulea, on the mucosal blood-flow and the gastric acid secretion as well as the pepsin secretion has been investigated in 15 patients. Caerulein administered at a dose rate of 0.1 mug/kg-h significantly inhibited the gastric mucosal blood-flow (p greater than 0.005) and the acid secretion (0.05 greater than p greater than 0.01), which had been stimulated by pentagastrin at a dose rate of 1.5 mug/kg-h. The pepsin secretion stimulated with pentagastrin also decreased, but not significantly. Caerulein at the above mentioned dose rate however caused a slight but not significant increase of the acid secretion stimulated by 40 mug histamine/kg-h. At the same time, gastric mucosal blood-flow and pepsin output decreased slightly but not significantly. Caerulein given alone stimulates acid secretion, yet it causes a significant reduction of the acid output when administered together with pentagastrin. This response has to be explained by the fact, that the similar chemical structure of pentagastrin and caerulein leads to a competitive inhibition. The mucosal blood-flow of the stomach measured with the heat-clearance technique also decreases with the administration of caerulein after pentagastrin stimulation. The fact that the mucosal blood-flow remains unchanged after the administration of histamine, suggests that the reduction in mucosal blood-flow observed with pentagastrin is a consequence and not the cause of the acid inhibition occurring at the same stage.

Adult↗
PubMed1975

[Endocrine and morphological investigation in undescended testis (author's transl)].

Determination of the basal and LH-RH-stimulated luteinizing hormone (LH) levels as well as testicular morphology in patients with surgically treated (n equals 112) and non-treated (n equal 96) undescended testes gave the following results: Unilateral of bilateral undescended testes are probably a form of primary, secondary or tertiary hypogonadism. In a high percentage abnormal basal and stimulated serum-LH values can be demonstrated. The testosterone values are within normal limits. The gonadal tissue damage in the abnormally situated testes of prepubertal boys seem to be congenital. With increasing duration of the malposition, particularly after the onset of puberty, a secondary tissue degeneration in the dystopic testis occurs. The damaging influence on the testicular tissue caused by the abnormal position seems to take place mostly at the end of prepuberty. A decrease in the number of spermatogonia in the tubuli of dystopic testes during the first 2 years of life is physiological. A surgical repositioning of the dystopic testis into the scrotum within the first 2 years of life is not indicated. Damage of gonadal tissue in the scrotal testis caused by the dystopic testis in unilateral maldescent could not be demonstrated. The optimal space for orchidopexy is between the third and fifth year of life.

Adolescent↗
PubMed1975

[Embryotoxicity and teratogenicity of derivatives of 1,3-indandion (author's transl)].

The embryotoxicity and teratogenicity of 1,3-indandion and of 3 of its derivatives were proved. Pregnant SWS mice were given single i.p. injections on day 9 of gestation. A mixture of physiologic saline and TWEEN20 (3:1) was used as a solvent. The results refute the hypothesis of the action of thalidomide as an acylating agent responsible for the embryotoxic and teratogenic effect. The results favor instead the hypothesis of an intercalation of the flat purine-like molecule moieties of thalidomide and some of its analogues between base pairs of the DNA double helix.

Animals↗
PubMed1975

Endoscopic findings of maxillary sinus after middle face fractures.

Of 93 patients with fractures of the mid-face who appeared for postoperative check-up, 25 were selected by chance for sinuscopy of the maxillary sinus. Chronic inflammatory mucosal changes occurred in 35 per cent; other pathological sequelae included solitary polyps, mucocele, scarry synechia, and prolapse of orbital fat and osteoma. In spite of these findings, all patients were free of complaints. The primary surgical revision was therefore declined in favour of a waiting attitude. For the diagnostic clarification of late complications, sinuscopy with Hopkin's optics offers a simple and efficient procedure, which should be routinely utilised.

Cicatrix↗
PubMed1975

Effect of radiation injury on the growing face.

The literature on the effect of ionizing radiations on developing and rapidly growing tissue has been reviewed, and the effect especially on children who received radiation therapy in the Clinic for Maxillo-Facial and Plastic Surgery of the University of Dusseldorf for various tumours of the head and neck presented. Our findings indicate that we do not yet know the minimal irradiation dosage that may cause growth retardation in infants and children. It has therefore been suggested that surgery should be more frequently considered in the treatment of childhood tumours, since this caused less side effect, and reconstructive surgery is today able to do much for patients who have had parts of their jaws resected.

Adolescent↗
PubMed1975

On the biological behaviour of basaliomas.

On the basis of our experience in 250 clinically and histologically proved cases of basaliomas, these tumours are classified as benign. Facts which seem to argue in favour of malignancy are refuted systematically. The criteria of the nature of carcinomas therefore do not apply to basalioma. Nevertheless the fact should not lead to underestimation of these tumours and to inadequate treatment.

Basal Cell Carcinoma↗