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H Klosterhalfen

Publications and source records attributed to H Klosterhalfen.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Pyelonephritic scar formation].

Pyelonephritic scars almost never develop after urinary tract infections alone, but require in addition certain risk factors. The most important risk factors are: vesicoureteral reflux, intrarenal reflux, obstructive uropathy, and nephrolithiasis. Most of the pyelonephritic scars develop in early childhood, where we find the combination of vesicoureteral reflux, intrarenal reflux, and urinary tract infections. Urinary tract infections alone almost never result in pyelonephritic scars. After the age of 3 years the risk to develop pyelonephritic scars is not more than 10% in those with the combination of urinary tract infections and vesicoureteral reflux. In this age group the risk to develop pyelonephritic scars is not altered by antireflux operation.

Adult↗
PubMed1986

[Determination of steroid receptors in prostate cancer: possibilities and limits].

In most cases, the prostatic carcinoma (PCA) is a hormone-dependent malignant tumor. Since sexual steroids seem to act upon their target organs by means of specific steroid receptors the determination of receptor concentration in PCA is of great theoretical and practical interest. The state of art of receptor research in PCA can be summarized as follows: 1. The prognostic relevance of receptor determinations in PCA is controversial. The contradictory assessments of the value of receptor measurements may be mainly caused by methodical problems. 2. A possible heterogeneity of the receptor distribution in PCA tissue can not be detected by biochemical receptor determinations. 3. This heterogeneity could be one reason for a lack of response to endocrine therapy in cases which are biochemically receptor-rich (selection of receptor-poor cell clones). 4. The available (immuno)histochemical fluorescence techniques, which have been developed for direct detection of heterogeneous receptor distribution in the tissue, are neither sufficiently sensitive nor specific. 5. It is an open question whether the development of an appropriate (immuno)histochemical method will succeed.

Humans↗
PubMed1983

[Pathogenesis and therapy of rupture of the transplanted kidney. Experiences in 186 transplantations].

Ruptures after kidney transplantations within the first two postoperative weeks were observed in 10.5% in adults and in 12.1% in children. In all cases acute rejection was demonstrable histologically. Immediately following diagnosis and intraoperatively at the latest first measures consisted of treatment of rejection using methylprednisolone as bolus. Operative care was always successful if visible detumescence of the organ following bolus treatment occurred. In one case surgery could be evaded by early treatment of rejection. Successfully treated ruptured kidneys do not differ in their long term results from kidneys which have undergone acute rejection in the early stage after transplantation. Rupture of the transplant is interpreted as special form of acute rejection.

Adolescent↗
PubMed1983

[Curative radiotherapy in stage C prostatic carcinoma. Experiences with radiotherapy-endocrine treatment].

In a prospective study 209 patients with prostatic cancer stage C who were seen between 1968-1974 received endocrine treatment and radiotherapy (6000 r) of the prostate without inclusion of regional lymph nodes. The patients were seen every 6 months up to 8 years. 247 transrectal biopsies and 7 transurethral resections of the prostate were performed. The analysis of the biopsies revealed that the combined endocrine and radiotherapy is followed by tumor neutralisation of about 70% in highly differentiated prostatic cancers and less effective in lower differentiated tumors. 80% of biopsies from tumors responding to therapy still show tumor cells. The 5-year-survival corresponded with tumor regression and tumor size. However a prognosis on the basis of these findings is not possible for the individual case.

Adenocarcinoma↗
PubMed1983

[Surgical results of epididymovasostomy and vaso-vasostomy].

In the Urology Clinic of the University of Hamburg 326 epididymo-vasostomies have been done. A follow-up of 241 men was possible. Bilateral anastomosis resulted in a 47% permeability; after unilateral recanalisation a patency-rate of 32% was obtained. Vaso-vasotomy after vasoresection was performed in 56 men. Following a splinted one-layer anastomosis, which we abandoned in the meantime, patency was obtained in 64% of patients. Current techniques in one or two-layers without a splint resulted in a 88% permeability. The double layer anastomosis does not offer an advantage over the one-layer method.

Epididymis↗
PubMed1982

Comparison of steroid concentrations in venous and arterial blood across the human testis. Unconjugated 5 alpha-androstane-3 beta, 17 beta-diol: an important androgen metabolite of the human testicular-epididymal unit.

By means of specific radioimmunoassays unconjugated testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol and estradiol-17 beta as well as testosterone-glucosiduronate were estimated in the plasma of the spermatic vein and artery simultaneously with the determination in peripheral venous and arterial plasma in ten male patients undergoing orchiectomy for prostatic cancer. The following results were obtained: A positive concentration gradient was found for all steroids. The testicular "secretion" of 5 alpha-androstane-3 beta, 17 beta-diol was established for the first time. The venous-arterial transfer of the mentioned steroids within the plexus pampiniformis yielded the following figures: 5.1%; 17.4%; 6.5%; 5.4% 5.1% and 6.5%, respectively. The testicular and/or epididymal origin of the different steroids was calculated to be of the following order of magnitude (mean values): Dihydrotestosterone 28%, 5 alpha-androstane-3 alpha, 17 beta-diol 45%, 5 alpha-androstane-3 beta, 17 beta-diol about 100% estradiol-17 beta 63% and testosterone-glucosiduronate 3%.

Aged↗
PubMed1982

[Pathogenic mechanism, morphology, diagnosis and therapy of the rejection of the transplanted kidney].

A review of renal rejection is given. The immunology, morphology, clinical presentation, diagnosis and therapy of hyperacute, accelerated, acute and chronic rejection is given. Own data are given showing that repeated bedside renograms and repeated bedside sonograms are extremely helpful in confirming the rejection diagnosis especially in anuric patients. New fast fixation method is described, so morphological workup can be done within 4 h after renal biopsy is taken.

Biopsy↗
PubMed1981

The value of coagulum pyelolithotomy.

Coagulum pyelolithotomy is a time-saving and tissue-conserving method which minimizes the danger of small crystallizations being left behind for new stone formation. A coagulum of excellent elasticity and tenacity can be obtained from the following mixture: first syringe, 20 ml thrombocyte-enriched plasma plus 5 ml human fibrinogen, and second syringe, 1 ml thrombin plus 4 ml calcium chloride. During the last 7 years this procedure has been employed in 120 selected patients; of these 84 involved multiple stones and 36 a single stone in a dilated intrarenal system. In only six cases were there residual caliceal fragments. The risk of hepatitis seems to be negligible since (1) only HBsAG-negative plasma and blood extracts are used, and (2) a comparison of two groups of 120 pyelolithotomies, with and without the coagulum, showed only two cases of hepatitis in each group while preoperative hepatitis occurred in five and seven cases, respectively. The enzymatic action or urokinase ensures that missing fibrin particles are dissolved before encrustation can occur. All free stones are caught and extracted with the coagulum. In 23% of cases additional fragments, not indicated by preoperative X-rays, were extracted as well.

Blood Coagulation↗
PubMed1981

[The bladder neck suspension according to Stamey-Pereyra for stress urinary incontinence (author's transl)].

The bladder neck suspension technique according to Stamey and Pereyra are described. 89% of 50 patients with stress urinary incontinence were cured regardless of previous operations. The technique proved to be simple and effective even if scarring from previous operations are present. There is no compression of the urethra. The bladder neck suspension should be widely used to cure stress urinary incontinence in the female.

Adult↗
PubMed1980

[Vasectomy].

Explore the source record for details and available documents.

Humans↗
PubMed1980

[Bioavailability of cyproterone acetate after oral and intramuscular application in men (author's transl)].

Cyproterone acetate was administered orally and intramuscularly to 5 male patients. The level of the active substance in plasma was monitored at intervals during the period of application using radioimmunoassay specific for cyproterone acetate. The areas under the drug level curves were similar after oral and intramuscular application of cyproterone acetate when taking into consideration the different doses used. Accordingly, cyproterone acetate is not dependent upon a "first-pass" effect. The bioavailability of the active substance was complete following oral application.

Administration, Oral↗
PubMed1980

[Hypophysectomy in the advanced stage of carcinoma of the prostate (author's transl)].

22 patients with advanced prostatic cancer underwent transnasal-transsphenoidal hypophysectomy. 2 patients died immediately after the operation, when this method was introduced. Of 19 patients, who were followed at short time intervalls, 13 = 68,5% showed a good remission, which lasted on an average of 5.5 (3-8) months. The survival time of these patients with a good remission was 11.5 months, whereas in patients without any remission it was 4.8 months. We recommend the hypophysectomy in individual cases as a possible form of treatment, which might lead to relief of pain and to objective tumor remission.

Humans↗