Search PubMed⌕ Search

Biomedical subjects

H Huber

Publications and source records attributed to H Huber.

At least 289 records · Page 16Linked to original sources
PubMed1977

[Penicillin-induced immunhaemolytic anaemia. In vitro studies using separated monocytes (author's transl)].

Under certain conditions human monocytes were able to bind and ingest red cell-antibody complexes in vitro. Using penicillincoated red cells and purified monocytes we investigated sera of patients with penicillin allergy. It was shown that sera containing IgG-antibodies against penicillin induced the binding of penicillin-coated red cells to isolated monocytes provided IgG-antibodies of high titer were present. Inhibition and absorption tests demonstrated the specificity of the reaction in terms of IgG-antibodies and the drug. Monocyte binding was also studied in respect to the cross reactivity of penicillin antibodies and cephalosporins. We concluded that antipenicillin-antibodies of the IgG-class were able to induce an immunphagocytosis in vitro, if the drug was present in the test system. The reaction was dependent on the amount of antibodies of the IgG-class.

Anemia, Hemolytic↗
PubMed1977

[The differentiation of human peripheral blood lymphocytes by immunological methods. III. Results in acute lymphoblastic leukemia (author's transl)].

In 47 patients with acute lymphoblastic leukemia surface markers were evaluated on mononuclear cells of the peripheral blood as well as in some cases on bone marrow lymphocytes. The lymphocytes were characterized by their binding capacity for sheep red blood cells, the demonstration of Fc-receptors, complement receptors as well as surface immunoglobulins. In 6 of 23 untreated patients the blasts bound sheep red blood cells spontaneously (T-ALL), in two of these six cases the lymphoblasts had simultaneously receptors for complement. In a further patients the lymphoblasts had complement- and Fc-receptors. The blasts of 16 of 23 patients were negative in respect to the markers tested (O-ALL). By comparing two groups of patients--one with positive cells, one unreactive--the clinical features differed: the marker positive group showed a predominance of male patients, 5 of 7 patients had a massive mediastinal mass and the remission rate was lower than in the group with positive blasts. 24 patients in remission under maintance treatment had a decreased percentage of rosette forming lymphocytes as well as lymphocytes with surface immunoglobulins and Fc-receptors. There existed some correlation between the percentage of rosette forming lymphocytes and the clinical course: patients with complications had lower percentages of rosette forming lymphocytes than patients with a favourable course.

Adolescent↗
PubMed1977

[Cytostatic therapy of metastasizing cancers: therapeutic indications and limitations (author's transl)].

The role of cytostatic drugs in the treatment of patients with advanced, metastasizing tumours and certain-therapeutic regimes are discussed in respect to the following tumours: breast cancer, gynaecological tumours, urinary tract cancers, tumours of the head and neck, lung cancer and bone and soft tissue sarcomas. Recent progress in the management of these patients is outlined, whilst the limitations of cytotoxic treatment, with the inherent possibility of potentially fatal complications, are emphasized.

Antineoplastic Agents↗
PubMed1977

[T-cell lymphoma (author's transl)].

The percentage of T- and B-lymphocytes was determined by means of surface markers in 190 patients suffering from various lymphoproliferative disease. Characteristic T-cell lymphomas were diagnosed in 8 patients: 2 of these patients suffered from acute leukaemia, 2 from lymphoblastic lymphoma, 3 from mycosis fungoides and one from the Sézary syndrome. The clinical course of the disease in these patients, the clinical picture and the results obtained with various surface markers and with unspecific mitogens are described and discussed.

Adult↗
PubMed1977

[Tumorous diseases of the lymphatic system (in 2 parts)].

Diagnostic approaches in the management of Hodgkin's Disease and Non Hodgkin Lymphomas are discussed. The importance of recent histological classifications in Non Hodgkin Lymphomas is emphasized particularly with respect to the differentiation between lymphomas of "low grade" and "high grade" malignancy. Complication in the course of treatment in these patients are reviewed and the therapeutic implications of particular organ involvement are summarized.

Biopsy↗
PubMed1976

Immunological characterization of lymphoproliferative disorders by membrane markers.

The characterization of lymphocyte subpopulations by means of surface markers improved our understanding of the immunopathology of lymphoproliferative disorders. In chronic lymphocytic leukemia an accumulation of B-lymphocytes have been documented. The antibody deficiency syndrome in these patients might well reflect a maturation defect of the leukemic B-lymphocytes. In patients with Hodgkin's disease the relative number of B- and T-lymphocytes in the blood was not markedly altered in comparison to normal controls. An increased proliferation primarily of T-lymphocytes however, might suggest their accelerated turnover as an indication of the host response. In most patients with "Non-Hodgkin" lymphomas high numbers of B-lymphocytes were found in affected lymph nodes, and these appear occasionally in the peripheral blood. Differences in immunopathological manifestations of the various subgroups of the "Non-Hodgkin" lymphomas are emphasized and the rare occurrence of lymphomas of T-lymphocytes (mainly observed in lymphoblastic lymphomas and in Sézary syndrome) is discussed. Immunopathological alterations in immunocytomas and the myelomas are considered in respect to the involvement of B-lymphocytes at different stages of maturation.

B-Lymphocytes↗
PubMed1976

[Rosette tests in lymphoproliferative diseases].

The percentage and absolute count of B- and T-lymphocytes in the peripheral blood of 170 patients with various lymphoproliferative diseases was determined. T-lymphocytes were assessed by their capacity to form rosettes with unsensitized neuraminidase treated sheep red blood cells, and B-lymphocytes by their capacity to bind immune-complement complexes. The results in CLL, in non-Hodgkin lymphoma and in Hodgkin's disease are discussed with respect to the immunopathology of these diseases.

B-Lymphocytes↗
PubMed1976

Reactive microglia with membrane features of mononuclear phagocytes.

An inflammatory response was induced by the implantation of cover-slips into the brains of rabbits. The cytomorphology of the glass-adhering cells, their phagocytic properties and their enzymatic activity were characterized and these features were correlated with the presence of membrane markers. Mononuclear cells with foamy cytoplasm, with marked phagocytic potential and strong activity of nonspecific esterases consistently showed IgG- and C-receptor activity. Multinuclear giant cells, which increased in number after prolonged implantation, exhibited comparable features. In contrast, mononuclear cells of fusiform appearance with a low activity of nonspecific esterases and a poor phagocytic potential lacked the IgG-receptor. A close relationship between the mononuclear phagocytic cell and reactive microglia is postulated. The authors conclude that the inflammatory response observed under their test conditions was characterized by the prevalence of phagocytic cells with membrane characteristics of the monocyte-macrophage series.

Acid Phosphatase↗
PubMed1976

Antibodies for T lymphocytes in systemic lupus erythematosus.

Sera of twenty-four patients with systemic lupus erythematosus were evaluated for antibodies cytotoxic for autologous lymphocytes. Such antibodies were domenstrable in twenty-two of these sera, whereas only one out of twenty patients with other connective tissue or lymphoproliferative disease showed a positive test. The antibodies remained detectable even when the patients went into remission. Sera containing the lymphocytotoxic antibodies were tested on cell fractions enriched for T or B lymphocytes. Primarily T lumphocytes wree affected by these antibodies. The presence of antibodies cytotoxic for T lymphocytes corresponded with a deficit of circulating T lymphocytes observed in most of our patients with systemic lupus erythematosys.

Adolescent↗