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Biomedical subjects

H Heine

Publications and source records attributed to H Heine.

At least 127 records · Page 7Linked to original sources
PubMed1978

[Viral acanthomas and specialized forms of keratinosome "membrane coating granules" (author's transl)].

In the case of viral acanthomas, the stratum spinosum and granulosum presents ballooned cells which contain all transitional stages from multivesicular bodies (MVB) to keratinosomes. A particularity in condylomata acuminata are the "wagon-wheel" bodies. These structures are typical for the non keratinazed squamous epithelium. The participation of intercellular extruded "wagon-wheel" bodies, MVB and atypical keratinosomes on an irregular baso-apical diffusion-barrier in the epidermis of cases with viral acanthomas has been discussed. On the basis of the relation seen between MVB and the Golgi-apparatus, their transition to partially atypical keratinosomes in cases of viral acanthomas and their "expulsion" into the intercellular space could indicate that in keratinozytes the enzymatically regulated feed-back between the cellular surface and the capability to synthesize is changed by viral agents. The interference appears to manifest itself in the Golgi-apparatus and also appears to be "specified" by the terrain present.

Condylomata Acuminata↗
PubMed1978

[Experimental investigation of thoracic aorta myocytes in mice. Contribution to the problem of the cause of arteriosclerosis].

The reactivity of myocytes has been ultrastructurally investigated. Pieces of aorta thoracic from mice were organ-cultured on the chorioallantoic membrane of chicken eggs incubated for 14 days. The outstanding finding were individual myocytes of the media--probably in a particular cytoenergetic stage--undergoing necrosis. They were enclosed from almost unaffected myocytes. Transferred to in vivo conditions, these findings may serve as a model for a participation of myocytes in the devleopment of disseminated multifocal arteriosclerotic plaques. The reactivity of the myocytes as to their ability of proteoglycan and lipid synthesis was opposed to Benditt's hypothesis of the genesis of an arteriosclerotic plaque caused by a monoclonal cell line originating from a mutated myocyte of the artery wall near the site of the plaque. The hypothesis of Kaunitz has been discussed, according to which the high serum cholesterin level with severe arteriosclerosis may be rather a consequence of cholesterin synthesis by the 'reparative' tissue of the arteriosclerotic lesion than its reason.

Animals↗
PubMed1978

[Viral acanthomas and specialized forms of keratinosome "membrane coating granules" (author's transl)].

In the case of viral acanthomas, the stratum spinosum and granulosum presents ballooned cells which contain all transitional stages from multivesicular bodies (MVB) to keratinosomes. A particularity in condylomata acuminata are the "wagon-wheel" bodies. These structures are typical for the non keratinazed squamous epithelium. The participation of intercellular extruded "wagon-wheel" bodies, MVB and atypical keratinosomes on an irregular baso-apical diffusion-barrier in the epidermis of cases with viral acanthomas has been discussed. On the basis of the relation seen between MVB and the Golgi-apparatus, their transition to partially atypical keratinosomes in cases of viral acanthomas and their "expulsion" into the intercellular space could indicate that in keratinozytes the enzymatically regulated feed-back between the cellular surface and the capability to synthesize is changed by viral agents. The interference appears to manifest itself in the Golgi-apparatus and also appears to be "specified" by the terrain present.

Animals↗
PubMed1977

[Annulate nexus and "virus like particles" (author's transl)].

Dependent on the direction in which the specimens are sectioned annular shaped nexus of neighbouring cell membranes may be misinterpreted as "virus like particles". It is suggested that many of the "virus like particles" described in tumor research may be annulate nexus.

Animals↗
PubMed1977

Ultrastructural study of a hitherto unknown disturbance of the synthesis of collagen precursor molecules in human cutis.

The ultrastructural characteristics of on hitherto unknown disturbance of collagen precursor molecules in human skin were studied. A severe disturbance of the synthesis of collagen exists at the procollagen stage. The paracrystalline accumulation of a form of procollagen in the tubes of the smooth ER and an increase in its appearance in the extracellular space, distinguish this clinical picture from all other previously described connective tissue disorders, especially from Dermatosparaxis and Ehlers-Danlos syndrome type VII. For this clinical picture we suggest the name "Dermatosparaxis endoplasmatica".

Adult↗
PubMed1977

[Light- and electron microscopical investigation on the pathogenesis of Kaposi's sarcoma (author's transl)].

In Kaposi's sarcoma (K.S.) the regular metabolism between endothelial cell, extracellular matrix and fibrocyte is disturbed. Thereby the composition of the extracellular matrix change and via a feed-back to the CNS and hormonal system in return changes of endothelial cells and fibrocytes appear. Processing of misinformation sum up in transformation of fibrocytes to tumor cells and destruction of endothelial cells. Initial a widening of the interendothelial borders of the capillary bed seem to be of great importance for the pathogenesis of K.S., because for long time spaces lymphedemas preceed the tumor. With this immunoreactions occur which probably are accompanied by autoimmuno-processes

Aged↗
PubMed1977

[Comparative and functional morphology of musculus canalis ani in tetrapod mammals and primates].

Comparative anatomy of structure and function of the M. canalis ani in tetrapode mammals and primates is described for the first time. The muscle itself lies on the sphincter ani internus in the area between the anorectal ("pectinate") and anocutaneal ("white") lines and its circumference is intact around the entire anal canal. The canalis ani muscle orginates from the superior part of the sphincter ani internus and concomitantly receives additional fibers from the longitudinal muscle. Caudally the muscle dips back into the sphincter ani internus and, at the same time, a small portion of the fibers go to the longitudinal muscle and, likewise, a portion also sets itself on the perinaal skin. On the basis of its morphological relationship to the convoluted vessels of the rectal venous plexus, the canalis ani muscle appears to be able to complete the closing of the anus in the continence phase to such an extent that a complete closing of the anal lumen is guaranted.

Anal Canal↗
PubMed1977

[Origin and function of globular leukocytes].

The morphology of the globule leukocyte (GL) has been investigated by light and electron microscopy in normal (decidua of mouse placenta) and pathologically altered tissues (tumors of epidermis and mucous membrane in men). The results make it probable that the GL my originate from mast cells as well as from eosinophil granulocytes. The high content of basic proteins within the globules of GL has been interpreted as a nutritive function by this cell type to the surrounding tissue.

Animals↗
PubMed1977

[Syntropy of dermatochalasis and urticaria pigmentosa as sequelae of dermatosparaxis endoplasmatica].

A 44 years old male is reported who had aquired dermatochalasis and urticaria pigmentosa at the same time. This is interpreted as a subsequent phenomenon of a dermatosparaxis endoplasmatica. Clinic, histology and electron microscopy are elaborated. Systemic involvement is verified by x-rays. Histologically, predominant is the severe atrophy of the elastica, the collagenous degeneration, the presence of mastocytes, the subepidermal blister formation and the secondary xanthomatosis. The picture deviates from the common dermatosparaxis occuring in calves by the paracrystalline content of the procollagene in the endoplasmatic reticulum as verified by electron microscopy. A severe disturbance of the synthesis of collagene exists in the state of procollagene for which here the term "dermatosparaxis endoplasmatica" is suggested.

Adult↗
PubMed1977

[Ultrastructure of the contact between interstitial cells and myocardial cells in mammalian hearts].

By combination of light, electron-microscopical and histochemical findings in the myocardium of dog and mice, the hypothesis of an intimate contact between a widely branched interstitial cell type, rich in proteoglycans, and myocardial cells could be strengthened. The branches seem to penetrate the transversal tubular system of the myocardial cells. Functionally, this interstitial (mast cell-like) cell type might influence via proteoglycans - delivered into the transversal tubuli - the excitation phenomena of the myocardial cell membrane. One of the earliest pathomorphological changes in the myocardium, as revealed by the light-microscopie, is the disengagement of these interstitial cells and the myocardial cells. From this point of view the genesis of myocardial cell necrosis has been discussed.

Animals↗
PubMed1977

[Ultrastructural relationships between terminal vegetative nerve fibers, ground substance and differentiations of cell surface (author's transl)].

Ultrastructural findings concerning the terminal vegetative nerve formation indicate a functional coupling via proteoglycans of the extracellular matrix with effector cells. The biological function of proteoglycans in the ground substance and in surface coats of axons and cells are discussed in connection with fusiform varicose swellings along terminal vegetative nerve fibers. These contain accumulated vesicles which probably are active in releasing transmitter substances.

Animals↗
PubMed1976

[Ultrastructural investigations on the pathogenesis of hyperplasias and tumors of skin connective tissue (author's transl)].

Results of an ultrastructural investigation of 4 tumors resp. hyperplasias of skin (endometriom, lymphadenosis cutis benigna Bäfverstedt, mastozytom, oral papillomatosis) show that the substance of granules from mastcells and eosinophilic granulocytes influence the composition and synthesis of the groundsubstance and its fibrous materials. Synthesis of the groundsubstance by fibrocyte like cells can be affected by intracytoplasmic uptake of the granules or by liberated granules which can change the composition of the groundsubstance. Fibrocyte like cells can take up the granules direct from the groundsubstance and (or) possibly by intercytoplasmic bridges ("Fursome"). Composition and synthesis of groundsubstance and fibrous elements are related by a feedback system. Therefore an irregular composed groundsubstance cause an irregular synthesis by fibrocyte like cells and vice versa. From that a circulus vitiosus arise that, by our opinion, may contribute to the development of tumors, resp. hyperplasias of skin with essential participation of the connective tissue.

Adult↗
PubMed1976

Long-term tissue culture of epithelial-like cells from human skin (NCTC strain 2544). I. Measurement of viscosity.

Viscosities of cell suspensions of human skin epithelium (NCTC strain 2544) were determined by a Wells-Brookfield rotation viscosimeter. A structure viscosity may be postulated by the form of the viscosity curves at different shear-rates. At a cell number of 0.5 X 10(6) cells/ml a viscosity of 1.094 centipoise (25degrees C, shear-rate 230 s-1) could be found. Since a suspension of single cells may be easily formed mechanically (mopping) the NCTC 2544 cells are useful as investigational model regarding the investigation of membrane characteristics.

Cell Membrane↗