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Biomedical subjects

H Heine

Publications and source records attributed to H Heine.

At least 109 records · Page 6Linked to original sources
PubMed1981

[Antithrombotic prophylaxis of the complications of arteriosclerosis obliterans].

The clinical efficacy of antithrombolytic drugs in different combinations was studied on a large contingent of patients with cerebral, coronary atherosclerosis and obliterating atherosclerosis of the vessels. It was shown that regular administration of acetylsalicylic acid with coumarin derivatives prolongs life of patients with cardiovascular diseases and decreases the number of vascular catastrophes.

Anticoagulants↗
PubMed1981

[Development and functional morphology of the Weibel-Palade-bodies in endothelial cells (author's transl)].

Our results presented indicate a transformation of multivesicular bodies from the Golgi-apparatus into Weibel-Palade-Bodies (WPB). A morphological series of different developmental phases of the WPB can be demonstrated by an increase of a certain intervesicular electron dense material. There is a striking coincidence with early developmental phases of myocardial Z-band material. The WPB are directly related to the microfilament system of the endothelial cells. The capillary endothelium of diseases and tumors of the human skin show a drastic reduction of the WPB-microfilament system towards the central parts of the tissue changes; this is accompanied with a simultaneous reduction of the pinocytotic activities. The endothelial cells are transformed into a conical shape with nearly an occlusion of the capillary lumen and an opening of the interendothelial junctions. This is interpreted as a loss of tone rather than a contraction of endothelial cells.

Animals↗
PubMed1980

[Significance of multivesicular bodies in synthetic cell processes].

Phosphatase-positive and -negative multivesicular bodies (mvb) are discernable by ultrastructural and ultracytochemical findings. The phosphatase-negative mvb are actually not considered to belong to the group of lysosomes. Because, they are obviously involved in synthesizing the cell-specific lamellated bodies (i.e. multilamellated bodies of type II alveolarepithelium cells, keratinosomes, praemelanosomes). By studying the literature about ultrastructural findings in tumors we found that mvb are generally increased in number in tumor cells. The changes in structure of the tumor cell membrane might be interpreted in a way that the synthesizing ability of mvb would generally provide phospholipoproteins to adjust a structural steady state of cell membranes. Our findings suggest that the synthetical activities of the mvb are coupled with multi-enzyme complexes of the vesicle membranes. Obviously, these membranes originate fro the Golgi-apparatus being closely related to the smooth endoplasmic reticulum.

Animals↗
PubMed1979

[Synthesis of elastoidic fibers in the organ culture of human dermis (author's transl)].

Organ cultures of human dermal excisions placed on the chorioallantoic membrane (CAM) of incubated chick eggs showed that a elastoidic fiber type could be achieved under experimental conditions within 5 h. The stages leading up to fiber formation could very well be produced by fibrocytes as well as by the splitting of collagen fibrils. The microfibrils (lacking a periodicity and with a diameter of 60-100 A) are characterized by a strong capacity to bind carbohydrate-proteinrich complexes (proteoglycans and glycoproteins). These then aggregate to elastoidic fibers. The amorphous fiber center remains strongly attractive for binding cations. This fiber type is then compared to the (elastoidic) fibers present in senile Elastosis and Pseudoxanthoma elasticum. Finally, the possibility of using CAM-cultures as experimental means for simulating such diseases is discussed.

Animals↗
PubMed1979

[Information regulation in the vegetative periphery].

The importance of the proteoglycans (PG) of the extracellular matrix in regulating the information reaching the vegetative periphery is demonstrated. Information brought to the vegetative periphery by autonomic nerves and the microcirculatory system are coded by the PG, thereby changing their biochemical structure. These changes (i.e. degree of polymerisation, capacity of ion-exchange and water-binding, electrostatical tonus) stimulate via the specific cellglycocalyx the cAMP-adenylcyclase-system of the cells in the vegetative periphery. In this way the information becomes decoded and is followed by the enzymatically steered answer of the cell. The center for all of these relations is the fibrocyte. The fibrocytes form the metabolic active center in the vegetative periphery and answer to "informative" changes in the extracellular matrix with a situation-dependent synthesis of PG. The possibilities of modulating the intercellular transfer of informations --- various cell contacts, temporary intercytoplasmic connections (fusomes), the role of mastcells.

Autonomic Nervous System↗
PubMed1979

[Long-term course of aortic arch syndrome caused by arteriosclerosis].

The course of the extracranially conditioned cerebrovascular disease is characterized by a worse prognosis in comparison with the average population of the GDR (11 years older) and by increased cardiovascular complication rate (every fifth patient suffered a myocardial infarction, every fourth patient suffered an apoplexy). Younger age of manifestation and increasing number of concomitant diseases form the basis of a course which is altogether endangered by complications, which, however, compared with peripheral and coronary arteriosclerosis, is more favourable. Operative reconstruction of the path of a vessel leads to an enduring improvement of the picture of the complaint. The total prognosis corresponds to the so-called spontaneous course. Under permanent treatment with anticoagulants a retardation of the general progressing of arteriosclerosis and improvement of the survival rates is to be proved.

Aged↗
PubMed1979

[Clinical diagnosis and course of arteriosclerosis obliterans].

The great diagnostic importance of the clinical heart and circulation state as well as of the simple clinical functional tests in comparison to the apparative bloody and unbloody diagnostics is emphasized. Concerning the course the unfavourable prognosis is elaborated on the basis of the survival rates and the appearance of cardiovascular complications. The role of the essential prognostic influence factors, such as age of manifestation, concomitant diseases and long-term therapy is proved by instances. It is referred to the favourable effect of the prolonged treatment with anticoagulants on the prognosis quoad vitam and to the retardation of the cardiovascular progressing. The long-term dispensary care is generally recommended.

Angiography↗
PubMed1979

Origin and function of 'rod-like structures' in mitochondria.

Both organ culture (choriallantoic membrane) of striped muscle from mouse diaphragm and freeze-drying of myocardial cells presented very characteristic structures in mitochondria. The organ culture evidence 'rod-like structures' in the intracristal spaces of the cristae mitochondriales. It is believed that these structures are the central apparatus responsible for mitochondrial division. On the other hand, the freeze-dried mitochondria presented neither intracristal spaces nor a space in the outer mitochondrial membrane. Because these spaces appeared only after fixation and dehydration, it is discussed if they are really artifacts. The mitochondrial cristae appearing as united structures after the freeze-drying process have been compared to the rod-like structures appearing intracristally after organ culture and conventional preparation techniques.

Animals↗
PubMed1979

[Functional morphology and ultracytochemistry of the specific granules of atrial muscle cells in mammals].

The carbohydrate content of the specific granules of atrial muscle cells has been confirmed by ultracytochemical and ultrastructural findings. The carbohydrate proteins of the granules seem to consist mainly of proteoglycans, probably with a great content of dermatan sulfate. Therefore, in mammals only the atrial muscle cells seem to retain postnatally the capability of embryonic heart muscle cells to synthesize proteoglycans. Secreted into the blood of the atria and atrial coronary vessels, they may bind lipoproteins of the blood serum, especially the atherogenic low-density lipoproteins. On the other hand, the antithrombotic effect of proteoglycans could be able to prevent a raised coagulability of the blood in the heart cavities caused by the beat of the heart cusps.

Animals↗
PubMed1979

[Prevention of cardiovascular complications in manifest arteriosclerosis by the use of Micristine].

A long-term clinical trial in micristin-treated patients suffering from organic arterial circulatory disturbances is reported. Problems of therapy monitoring by determination of the ASA level in plasma and of control of platelet aggregation are discussed. Acute cardiovascular complications (myocardial infarction, stroke, acute vascular occlusion, amputation and angiographically demonstrated progression) were observed. The observation time did not suffice to establish statistically significant differences between micristin therapy anticoagulant treatment and basic cardiovascular therapy. The results are suggestive of a more beneficial effect of anticoagulant treatment.

Adenosine Diphosphate↗