Biomedical subjects

H Heine

Publications and source records attributed to H Heine.

At least 91 records · Page 5Linked to original sources

PubMed1983

[Cytidine monophosphatase (CMPase), a transport hydrolase of membrane-bound glycoconjugates].

Membrane bound glycoconjugates (glycoproteins, -lipids and proteoglycans) of the plasmalemmaa and of the cytoplasmic membrane tube system are responsible for essential cell function. Accordingly it is necessary to keep them in a proper functional state. Our results indicate a possible involvement of cytidine monophosphatase (CMPase) in these events. Study is published by Novikoff (1967) and Clermont et al. (1981) the CMPase being a hydrolase which participates to a major part in the sequestration process and vesicular packaging from the GERL system. The enzyme is carried on towards the cell surface bound to the membrane of transport vesicles. Our observations suggest a possible incorporation of glycoconjugates in the plasmalemm by involvement of CMPase. In addition, the enzyme takes part in the endocytotic reuptake of glycoconjugates having lost their complete function with recycling and rebuilding in the GERL and Golgi apparatus. By using antigen provoked mononuclear and neutrophilic leucocytes the membrane bound response of CMPase is seen to be very distinct. The same is true for enterocytes exposed for a short-time ischemia. A strictly localized appearance of the CMPase in close vicinity to the couplings of short-time ischaemic muscle fibres in apparently of relevancy fr restructuring and availability of membrane bound glycoconjugates. This suggest a direct influence on the mechanism of excitation-contraction couplings of skeletal muscle fibres.

Animals↗

PubMed1983

[Studies on central and peripheral hemodynamics using radiocardiography and Xenon-133 muscle clearance in patients with essential hypertension].

Examination of 80 patients with essential hypertension revealed a significant correlation between the tonus of peripheral muscular arterioles on the one hand, and the stage and duration of hypertension and age of the patients, on the other hand. The correlation between arteriolar tonus and indicators of cardiac pump function was less marked. The results confirmed the close relationship between changes of peripheral blood bed and development of hypertension. The use of 133Xe half-period for measuring the peripheral arteriolar tonus proved a simple, but informative method adding an important indicator of peripheral haemodynamics to the results of haemodynamic examination.

Adolescent↗

PubMed1983

Proteolytic enzymes and catabolism: enhanced release of granulocyte proteinases in uremic intoxication and during hemodialysis.

Proteinases are classified into four groups according to their catalytic mechanisms: the serine, cysteine (thiol), aspartic (carboxyl), and metallo-proteinases. Neutrophil granulocytes contain a variety of neutral proteinases and two acid proteinases. Lysosomal proteinases are released from cells during phagocytosis, cell death, or exposure to antigen-antibody complexes, complement factors, and toxins. Under pathological conditions, massive proteinase release may cause tissue injury and degradation of plasma proteins. Plasma proteolytic activity is controlled by inhibitors of blood systems (antithrombin III, C1 inhibitor, and plasmin inhibitor) and by inhibitors against proteinases of various body cells (alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, beta 1-collagenase inhibitor, and inter-alpha-trypsin inhibitor). Intracellular proteinases are controlled by different cytosolic inhibitors. In hypercatabolic states (septicemia, trauma, burns), the concentrations of many plasma proteins, including proteinase inhibitors, are decreased. Kallikrein-kinin, complement, and fibrinolytic systems may be activated, probably due to enhanced proteinase activity. In acute renal failure, there is a release of granulocyte neutral proteinases. The plasma concentration of the elastase-alpha 1-proteinase inhibitor complex is simultaneously increased. Granulocytes of chronically uremic patients treated with diet or regular dialysis have a slightly to markedly reduced proteinase content as compared with normal controls. There is a dramatic rise of the plasma elastase alpha 1-proteinase inhibitor complex during hemodialysis treatment.

Acute Kidney Injury↗

PubMed1983

[Post-traumatic cholecystitis].

Post-traumatic cholecystitis occurs mostly in young males 8-16 days after severe injury. Gallstones are of no importance in its pathogenesis. Circulatory shock causes severe damage to the small bowel and the liver, particles of the destroyed cells becoming endogenous toxins. Presumably an increased excretion of lysosomal proteases in the biliary duct takes place. This excretion reaches the gallbladder via the accessory ducts and may cause necrosis. Pain in the right upper quadrant, septic temperature and an increase of leucocytes, bilirubin and gamma-GT in the serum suggest this complication.

Acute Disease↗

PubMed1983

[Unfolding of the brain and secondary mandibular joint and face development in mammals: a synergetic and synchronous event].

The connection of phylogenesis and ontogenesis is discussed in terms of the interdependence of the development of face, secondary mandibular joint, and brain. The results show that phylogenesis can be explored from preadaptations which become functionally effective during ontogenesis. Therefore phylogenetically "old" functions will not be eliminated but functionally changed and then integrated into new ones. This is discussed as "synergetic events". Changes in the genetic material cannot be correlated with these functional changes, they are acausally connected. This is termed "synchronizition". Synergetic and synchronistic events together cause new functions thus forming archetypical organisms continuing evolution. It is further discussed that the essential role of ontogenesis during phylogenesis could be facilitated by an immaturity of the genome in the early embryological stages.

Adaptation, Physiological↗

PubMed1983

[Proteoglycan synthesis in the endothelium of embryonal vertebrate hearts: significance for the development of cardiovascular function].

The endothelium of the embryonic heart is able to synthetize proteoglycans (PG) as it is the myocardium. In the extracellular matrix, PG form highly polymeric visco-elastic networks, which besides others act as shock absorber. That is apparently of evidence for the modulation of embryonic heart actions. Because during the embryonic period the large arteries are simple endothelial tubes without having an elastic-muscular wall. That means the typical "windkessel" function such as dumping of pulse waves or a continues pressure distribution is not existent. The embryonic vessels are perfused like rigid tubes. The continuous rhythmic flow pattern in the endothelial tubes, necessary for perfusion of the different organs, is apparently compensated by a high initial pressure level initiated by the heart. It is concluded that the continuity of the pressure profile is caused by intracardial PG. The endothelial synthesis of the PG of the heart decreases with increasing development of the muscular wall of the vessels and disappears completely post partum.

Animals↗

PubMed1983