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Biomedical subjects

H Hayasaka

Publications and source records attributed to H Hayasaka.

At least 91 records · Page 5Linked to original sources
PubMed1980

Studies on the etiologic mechanism of anisakiasis. --2. Epidemiologic study of inhabitants and questionaire survey in Japan.

A nationwide investigation on the incidence of anisakiasis over a period of 5 years from 1973 through to 1977 was conducted by questionaire sent to 851 main medical centers throughout Japan. The number of cases for all Japanese for a period of 5 years were 334 cases of gastric anisakiasis and 45 intestinal anisakiasis. We investigated both a random group of 3,108 inhabitants of Hokkaido and 42 anisakiasis patients using skin test, indirect hemagglutination test and measurement of serum IgE. We have demonstrated that the etiologic mechanism of acute anisakiasis involved anaphylactic reaction as well as Arthus reaction in the digestive tract.

Adolescent↗
PubMed1979

Effects of aldosterone and dexamethasone on blood chemical mediators in endotoxin shock.

Although the pathogenesis of endotoxins shock is still a matter of speculation, we attach importance to chemical mediators in endotoxin shock. We measured chemical mediators such as histamine, serotonin, bradykinin and catecholamines and investigated the anti-toxic effects of aldosterone and dexamethasone on rabbits in endotoxin shock. Histamine, serotonin and catecholamines were measured by fluorometric assay. Bradykinin was measured by bioassay using rat uteri. The blood concentration of chemical mediators after endotoxin administration was elevated. Aldosterone and dexamethasone inhibited the release of chemical mediators, thereby preventing endotoxin shock.

Aldosterone↗
PubMed1978

Mutational biosynthesis of butirosin analogs. II. 3', 4'-Dideoxy-6'-N-methylbutirosins, new semisynthetic aminoglycosides.

A pair of new butirosin analogs was isolated from the fermentation broth obtained by cultivating a neamine-negative mutant of the butirosin-producing organism Bacillus circulans in the medium supplemented with 6'-N-methylgentamine C1a. These antibiotics were characterized and elucidated as 3', 4'-dideoxy-6'-N-methylbutirosins A and B (DMB-A & DMB-B), by chemical and spectroscopic studies. DMB-A and DMB-B exhibited broad-spectrum antibacterial activities with in vitro potency similar to or slightly less than that for the butirosin A, with the exception of strains of Pseudomonas aeruginosa and Serratia marcescens against which they exhibited activities equal to or slightly greater than that for butirosin A. As expected, they exhibited stronger activities against butirosin-resistant organisms which contain acetylating enzymes AAC(6')-I and AAC(6')-IV, and phosphorylating enzyme APH(3')-II. They were also active against some of the clinical isolates resistant to butirosins, dibekacin and/or gentamicin. The acute intravenous toxicity in mice of the DMB complex (B:70 APPROXIMATELY 80%) was somewhat less than that of the butirosin A.

Animals↗
PubMed1978

Macrolide antibiotics M-4365 produced by Micromonospora. III. In vitro antimicrobial activity of antibiotic M-4365G2 (de-epoxy rosamicin).

Antibiotic M-4365G2 (de-epoxy rosamicin) produced by Micromonospora capillata MCRL 0940 is a new basic 16-membered macrolide antibiotic with activity equal to or superior to erythromycin and josamycin against Gram-positive bacteria. Of interest are the high degree of activity against Gram-negative bacilli and mycoplasmas, and striking inhibitory effects against indole-producing Proteus spp. Bactericidal activity of M-4365G2 is also to be noticed.

Aminoglycosides↗