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Biomedical subjects

H Gall

Publications and source records attributed to H Gall.

At least 127 records · Page 7Linked to original sources

[Modern syphilis serology. Immunology, tests and their validity].

In the immunological chapter the appearance of the antibodies in several stages of the lues infection and the methods of demonstration are described. With the lipoid-antigen reactions and the antigen-specific tests modern lues serology can give an answer to the three important questions: Exists a lues infection? Is the demonstrated lues infection active? Was the treatment successful? To diagnose a lues infection one should carry out the Treponema Pallidum Haemagglutination (TPHA) test as screening reaction; the Fluorescent Treponemal Antibody Absorption (FTA-Abs) test should be used for confirmation. The quantitative Cardiolipin Microflocculation test (CMT) decides on the activity of the lues infection and can be used to follow up the effectiveness of treatment. In some cases the Treponema Pallidum Immobilization (TPI) test or the demonstration of the 19S-IgM-antibodies must be used for clarification.

Fluorescent Antibody Technique↗

[Protection of the skin].

The toxic or allergic contact dermatitis is the most frequent occupational disease of the skin. It is caused by repeated contact with irritant or sensitizing occupational substances. The aim of the skin protection is to prevent or at least to lessen the contact with these injuring substances. Protective gloves as well as skin protective unguents are of use for preventive skin protection. We differentiate two types of emulsions among the skin protective unguents: O/W-emulsions protect against injuring components, insoluble in water, and W/O-emulsions protect against injuring stuffs, soluble in water. The cleaning agents of the skin have to be chosen according to the degree and kind of the contamination; today surfactants such as soap and detergents are chiefly used. THe preserving skin protection is very important: with the regenerating care of the skin the water and fatty constituents of the injured skin are repaired.

Clothing↗

[Contact allergy due to the topical antiperspirant propantheline bromide (author's transl)].

After a treatment of 6 months with the antiperspirant Hydonan a contact dermatitis was found in the axillae of a 42 year-old soldier. Hydonan is a combination of 2 emphatic substances: aluminium hydrochloride and propantheline bromide. Aluminium hydrochloride is an adstringence substance, propantheline bromide is a topical active anticholinergic agent. As side-effect an irritation due to aluminium hydrochloride and a contact allergy due to propantheline bromide can occur. In our case there was a contact allergy to propantheline bromide 5% aq.

Adult↗

Characterization of a new aberration of the human Y chromosome by banding methods and DNA restriction endonuclease analysis.

Comparative cytogenetic analyses were performed with ten different banding methods on a previously undescribed, inherited structural aberration of a Y chromosome, and the results compared with those of normal Y chromosomes occurring in the same family. The value of the individual staining techniques in investigations of Y chromosomal aberrations is emphasized. The aberrant Y chromosome analyzed can be formally derived from an isodicentric Y chromosome for the short arm with a very terminal long-arm breakpoint, in which the centromere, an entire short arm, and the proximal region on one long arm was lost. This interpretation was confirmed by determining the amount of the two Y-specific DNA sequences (2.1 and 3.4 kb in length) by means of Hae III restriction endonuclease analysis. The karyotype-phenotype correlations in the men with this aberrant Y chromosome, especially the fertility dysfunctions (oligoasthenoteratozoospermia, cryptozoospermia), are discussed. The possibility of the existence of fertility factors involved in the control of spermatogenesis within the quinacrine-bright heterochromatic region of the Y long arm is presented.

Adult↗

[Varicocele and subfertility].

At first the anatomic conditions are represented: the anastomosis between the left and the right pampiniform plexus and the causes for the dominant occurrence on the left side of the idiopathic varicocele. The author deals with the consequences, anatomic changes and disturbances of the function caused by the varicocele as well as its targets. The relation between varicocele and subfertility is proved, in the course of which the importance of the progressive motility is accentuated. The theories of the mechanism of damage are discussed. The methods of treatment, ligation and sclerosing of the left internal spermatic vein are described; the results after the operation are compared.

Humans↗

[Allergic eczematous contact dermatitis due to fatty acid polypeptide condensates (author's transl)].

After an electrocardiogram an eczematous contact dermatitis was found on the skin of a 34-year-old soldier, where the contact of the leads had been fixed to the chest and extremities. 5 months later, he caught an eczematous contact dermatitis which spread over the face after irrigation of the external auditory meatus. In both cases, the contact allergen was a fatty acid polypeptide condensate. This article describes the production, properties and application of the fatty acid polypeptide condensates as well as effects and side-effects in comparison to other detergents.

Adult↗

[Improvement of male fertility through ligation of varicocele? A study of 100 subfertile varicocele patients three months after ligation (author's transl)].

With 100 subfertile varicocele patients, three months after ligation (high ligation of the left internal spermatic vein in accordance with Bernardi) had control spermiograms made. An improvement of sperm count (upgrade in a higher class according to MacLeod's partition) was found in 28% of the cases, whereas an improvement of progressive motility was found only in 13%. The percentage of patients reaching the normal value in sperm count of over 40 mill./ml increased from 23% to 39%. The increase in these patients came primarily from the class of 20--40 mill./ml. In progressive motility, there was an increase of patients reaching the standard value of over 40%, from 6 to 11. However, if sperm count and progressive motility together were evaluated in the individual patients after ligation, only 6 patients presented a normospermia, i.e. a sperm count of more than 40 mill./ml with normal progressive motility. Thus 94 of the 100 patients must be considered as subfertile three months after ligation. A significant fertility improvement through ligation of varicocele has not yet taken place.

Adult↗

[Circadian rhythm of plasma testosterone levels. III. Determination of the daily serum testosterone maximum].

Testosterone levels in plasma in 50 young males are found on a plateau between 07,00 h and 10,00 h. As this plateau represents the highest level throughout the day, it is necessary to take blood sample only once during this period. Therefore a statement about endocrine testicle function can be given by only one determination of testosterone between 07,00 h and 10,00 h. This faciliates endocrine examination in ambulant patients.

Adolescent↗

[Treatment of neurotic sleep disorders with the use of V. E. Frank's logotherapy].

V. E. Frankl's logotherapy is a useful method of treatment in the psychotherapy of neuroses. Its systematic approach to reorientation, the assistance it provides is adopting an optimistic outlook on life, and its dynamic character and comparative limitation in time make it ideal for outpatient therapy. Patients easily adopt its two recommendations, the "paradoxical intention" and "dereflection", and these have a capacity for overcoming symptoms. This frees the patient sufficiently to make it possible for him to deal with the causes of his crisis. Through analyzing his conflict with the environment he can arrive at a new synthesis and find a meaningful philosophy of life.

Adult↗

[The effect of varicocele on male fertility with particular consideration of progressive motility (author's transl)].

Two-hundred patients with varicocele were examined for fertility, which was found to have diminished in 75% of the cases because of a decreased sperm count (less than 40 million/ml); 40% of these, the largest group (categorized only with regard to oligospermia), had a sperm count of 21--40 million/ml. The most remarkable finding was restrained fertility in 90% of the cases because of decreased progressive motility (speed of forward progression). Here, the largest group (nearly 50%) was in the category of 21--30%. Decreased progressive motility was mostly combined with a diminished sperm count to an oligoasthenospermia. In 20% of the cases, however, fertility was restrained only by decreased progressive motility in the sense of an asthenospermia. The first effect, due to varicocele, is seen in decreased progressive motility. However, because spermatozoa acquire their progressive motility by means of maturation in the epididymis, the varicocele causes the first damage to the epididymis.

Cell Count↗

[Studies on the treatment of male infertility with kallikrein].

70 subfertile patients were given oral (600 K.U./daily) or parenteral (3 X 40 K.U./weekly) Kallikrein-treatment for seven weeks. Statistical evaluation of the findings yielded positive changes (level of significance alpha less than 1%) in cases of reduced spermatozoa count, motility, and morphology. In respect to clinical diagnosis the most satisfactory effects were achieved in cases of the vegetative congestion syndrome, which includes functional disturbances of the epididymis, the testicular outlet of spermatozoa, and the last phase of spermatid maturation. In cases of testis parenchyma disorders a true effect was not noted. Probably Kallikrein influences the function of epididymis and SERTOLIcells, which can be concluded by the results of the spermatological examinations in the course of the treatment. Because of the short duration of treatment, it is impossible to decide, wether the proliferation of the germinal epithelium is increased as well. A negative effect was observed in cases of chronic inflammations of the genital tract, the inflammatory process being activated by Kallikrein, which was not unexpected.

Administration, Oral↗

[Allergic reactions of the eczema type due to drugs (author's transl)].

Drug-induced allergic skin reactions of the eczema type may relatively frequently appear as allergic contact eczema or more rarely as "hematogenous contact eczema." In both types of eczema, a positive patch test to one or more allergens is essential for diagnosis. In 1971 and 1972, there were 85 patients with drug-induced eczema reactions (allergic reactions to the ointment bases and preservatives have not been taken into consideration). In 80 cases, topical applications were the contact allergens. The frequent contact allergies to benzocaine and Balsam of Peru seems significant. In 5 isolated cases we saw hematogenous contact eczema due to internal medication, e.g. with antibiotics.

Anti-Bacterial Agents↗