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Biomedical subjects

H Gall

Publications and source records attributed to H Gall.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Percutaneous sclerotherapy as primary treatment of testicular insufficiency in idiopathic varicocele].

Among 1217 percutaneous retrograde phlebographies of the left renal/testicular vein 1069 were performed for primary treatment of left-sided idiopathic varicocele. In 989 of these patients (92.5%) an insufficient testicular (internal spermatic) vein with reflux to the pampiniform plexus could be shown phlebographically, in 802 cases percutaneous sclerotherapy could be performed. This amounts 75.0% of patients with varicocele or 81.1% of the cases with a phlebographically proven testicular vein insufficiency. In this group percutaneous sclerotherapy has proven to be a safe and effective treatment of idiopathic varicocele on an outpatient basis and has replaced surgical ligation as method of choice. However, with anatomical and technical obstacles to sclerotherapy, especially in patients with varicocele but without phlebographic evidence of an insufficient testicular vein, surgery remains an essential means of therapy.

Adolescent↗
PubMed1986

[Corpus cavernosum autoinjection therapy: initial experiences in erectile dysfunction].

The cause of erectile dysfunction was evaluated by a multidisciplinary approach in 120 impotent patients. Out of these, the CCAT was proposed to 20 patients with vasculogenic erectile dysfunction, 19 of them accepted this therapy. The dosage of phentolamine mesylate-papaverin hydrochloride injection required was determined in each patient individually. Usually we injected initially 1 cc in one corpus cavernosum. Eighteen patients followed the regimen successfully at home. In 2 patients prolonged erections were observed, which were successfully relieved by simple corpus puncture, however, discontinuation of therapy was not necessary. CCAT failed in 1/19 patients with a severe venous leak. Follow up was carried out weekly.

Drug Therapy, Combination↗
PubMed1986

[Doppler sonography and phlebography in the detection of hemodynamically different varicocele types].

Using the bidirectional doppler sonography to evaluate patients with varicocele two haemodynamically different types of varicoceles, pressure-type and shunt-type, can be determined. By means of retrograde phlebography of the internal spermatic vein (testicular vein) in 44 patients with varicocele the pathophysiologic-anatomic equivalent of these two types could be demonstrated. Shunting veins are the cremasteric vein and deferential vein. The two types of varicoceles have a different effect on male fertility.

Hemodynamics↗
PubMed1986

[Percutaneous sclerotherapy of testicular vein insufficiency in persistent and recurrent varicocele].

Among 1217 retrograde phlebographies of left-sided idiopathic varicoceles 66 patients presented because of persistence or recurrence of varicocele, 34 of them after operation and 32 after sclerotherapy. After operation without success there was always - except for one case - a reflux passing the site of ligature. If persistence or recurrence of varicocele occurred after sclerotherapy, the testicular (internal spermatic) vein was most often found to be obliterated at the junction with the renal vein and the sonographically proven reflux went via collaterals or unidentified veins which prevented a repeat sclerotherapy. In 12 out of 32 patients after sclerotherapy a persistent main stem of the testicular vein allowed a second attempt of sclerotherapy. If sclerotherapy in patients after operation or previous sclerotherapy could be performed, it was an effective, low risk procedure on an outpatient basis just as in primary sclerotherapy of testicular vein insufficiency causing varicocele.

Humans↗
PubMed1985

Cell-culture studies on neurofibromatosis (von Recklinghausen's disease). III. Experiments on X-ray sensitivity.

The X-ray sensitivity of strains of fibroblast-like cells derived from peripheral neurofibromas of ten patients with neurofibromatosis was compared with that of 12 strains of skin fibroblasts derived from healthy donors. Quantitative parameters of the dose-dependent reduction in colony-forming ability did not differ significantly between these two groups of strains. The cloning efficiencies of nonirradiated controls varied within the same range in strains derived from patients and from healthy donors.

Cell Survival↗
PubMed1985

[Selective arteriography of the internal pudendal artery in posttraumatic erectile dysfunction].

102 patients with erectile dysfunction were evaluated by a multidisciplinary approach including measurement of the bulbocavernous reflex (BCR)-latency, cystometry, dynamic cavernosography and bilateral selective arteriography of the pudendal arteries. Seven patients had a posttraumatic source of their erectile failure. Three patients showed a mixed neurogenic-arteriogenic aetiology of erectile dysfunction, two patients had evidence of isolated arterial damage, one patient had a venous and one an isolated neurogenic cause of erectile dysfunction. The passage of pudendal-penile vessels and nerves through the urogenital diaphragm is the most vulnerable portion of its way through the pelvis. Ruptures of the prostatomembranous urethra are frequently accompanied by injury to the pudendal-penile vessels and nerves, thus causing erectile dysfunction.

Accidents, Traffic↗
PubMed1985

[Familial, structural aberration of the Y chromosome with fertility disorders].

Cytogenetic studies on a patient with Klinefelter's syndrome revealed an inherited, structural aberration of the Y-chromosome which has not been described before. The aberrant Y-chromosome was characterized by eight different banding methods. The value of individual staining techniques in studies on Y-heterochromatin aberrations is emphasized. Analysis of the cytogenetic studies (banding methods, restriction endonuclease of DNA, and measurement of the length of the Y-chromosome) permits an interpretation to be made on how the aberrant Y-chromosome originated. The functions of the Y-chromosome are discussed. The decrease in fertility (cryptozoospermia) in the two brothers with the same aberrant Y-chromosome was striking.

Adolescent↗
PubMed1984

Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.

The clinical effects and pharmacokinetics of high-dose uridine were determined in seven patients with advanced-stage cancer and in one healthy volunteer. Uridine was also examined for its effect on 5-fluorouracil toxicity in two patients. Uridine was administered as a 1-hr i.v. infusion at doses of 1 to 12 g/sq m. Plasma and urine samples were analyzed for uridine and uracil using high-pressure liquid chromatography. In 23 courses of uridine alone, the only toxicity observed was transient shivering after one of two courses at 12 g/sq m. This side effect was also seen after administration of uridine (10 g/sq m) during combination with 5-fluorouracil. The pretreatment plasma uridine concentration was elevated from low micromolar to millimolar levels with uridine administration at doses up to 12 g/sq m. Maximal areas under the concentration-time curve were about 5 mmol/liter/hr. Both peak plasma level and area under the curve for uridine increased linearly with dose. Uridine plasma decay curves were biphasic with a terminal half-life of 118 min. Half-life, volume of distribution (634 ml/kg), and total clearance (4.98 ml/kg/min) appeared to be independent of dose. Plasma uracil concentration increased gradually after administration of uridine to plateau levels. Maximal plasma uracil concentrations were about one-tenth that of peak uridine concentrations. The plasma uracil level declined with a half-life of about 40 min after uridine levels decreased to 300 microM. Total urinary excretion of uridine was 24% of the dose, while the amount of uracil recovered in urine was 3.4%. In two patients, uridine rescue was attempted during 5-fluorouracil dose escalation. Uridine at 5 to 6 g/sq m given on 1 or on 2 days after 5-fluorouracil did not prevent myelosuppression and gastrointestinal toxicity associated with increasing plasma concentrations of 5-fluorouracil. These data show that uridine administered as a 1-hr infusion at doses which provide peak plasma uridine concentrations in the millimolar range is well tolerated. Rapid elimination of uridine primarily due to catabolism results in modest exposure to substantially elevated plasma uridine concentrations. Preliminary findings suggest that prolonged treatment with uridine may be required to test its potential to rescue patients from 5-fluorouracil toxicity.

Adult↗
PubMed1984

[Late results following sclerotherapy of varicocele].

Between May 1981 and December 1982 244 patients with varicocele were scheduled for percutaneous sclerotherapy which is performed as an out-patient procedure. In around 80% of the patients sclerotherapy was possible. Failures were due to anatomical and technical factors. Three months after treatment a persisting varicocele was observed in 3.3% as evidenced by control phlebography; 3.9% of our patients developed a painful induration of the plexus pampiniformis which necessitated a 3-day hospitalization. Six months after sclerotherapy spermiography was repeated and compared to the pretreatment results: in 50% of the patients the sperm density was significantly improved, however, sperm morphology and mobility remained virtually unchanged. The sclerotherapy of varicoceles can be recommended as an alternative procedure to surgery. The effect on sperm quality of both therapies is equal, but the sclerotherapy is performed as an outpatient procedure (sick-leave 2 days), is cheaper, better tolerated and has a lower rate of persisting varicoceles than surgical repair.

Adult↗
PubMed1983

Cell culture studies on neurofibromatosis (von Recklinghausen). II. Occurrence of glial cells in primary cultures of peripheral neurofibromas.

The occurrence of glial cells in primary cultures established from peripheral neurofibromas of 18 patients with neurofibromatosis (von Recklinghausen) is described. The spindle-shaped cells can be distinguished from fibroblasts on the basis of morphological and ultrastructural criteria. As demonstrated by immunocytochemical analysis, the spindle cells express S-100 protein. Neither glial fibrillar acidic protein nor myelin basic protein can be detected in these cells. In many respects the spindle cells resemble immature Schwann cells in culture.

Cells, Cultured↗
PubMed1983

[Allergies to dental materials and dental pharmacologic agents].

Allergic reactions to dental materials and remedies cause stomatitis in the patient and a contact dermatitis in the dental personnel. Topical contact (acrylic resin denture materials, heat accumulation, plaques on the denture) and endogenic (symptom of internal and psychiatric illnesses) factors are the cause for denture sore mouth. In metallic alloys corrosions and electric currents can effect an irritation to the oral mucosa. The application of amalgam fillings can possibly result in a mercurialism. Dental remedies used for treatment of wounds and dental roots are potent sensitizers. Surface anesthetics with tetracaine are the most frequent contact allergens for dentists. Injectable local anesthetics produce anaphylactic type reactions as well as toxic side-effects in the patient.

Anesthesia, Dental↗
PubMed1983

[Hemodynamic studies on varicocele using bidirectional ultrasound Doppler sonography].

At first the ultrasonic Doppler sonography is described in the evaluation of the retrograde venous blood flow in a varicocele. With the Doppler stethoscope the incidence of venous reflux amounted to 70% in young men aged from 19 to 22 years. At physical examination a palpable varicocele was detected in 55% of the cases. By the bidirectional technique you can define various haemodynamic types of varicoceles: "pressure-type" and "shunt-type". 205 patients with varicoceles were examined by bidirectional Doppler probe. The Doppler recording was correlated with the severity of varicocele. In small varicoceles the "pressure-type" is found most frequently, while in large varicoceles the "shunt-type" occurs.

Adult↗