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Biomedical subjects

H Fujimoto

Publications and source records attributed to H Fujimoto.

At least 235 records · Page 13Linked to original sources
PubMed1988

Endoscopic Nd-YAG laser therapy in upper gastrointestinal tract.

Forty-seven patients with gastrointestinal bleeding, benign tumor and malignancy were treated by YAG-laser therapy from 1980 to 1987. For active bleeding, laser coagulation was effective in inducing hemostasis. This therapy was also effective for the potential bleeding lesions. Benign sessile lesions such as polyp and adenoma were completely treated by laser vaporization. In cases with malignancy, the small-sized early gastric cancer (less than 15 mm in diameter) could be effectively treated. Among them, one case was followed up for as long as 82 months without any sign of recurrence. On the other hand, poor results were obtained in the cases suffering from early esophageal cancer due to incomplete laser irradiation resulting from the fear of penetration through the thin-walled esophageal mucosa. However, for the malignant stricture, the laser therapy was useful to relieve the lesion due to the regression of the tumor size. After the treatment, the patient was able to take meals orally. The above data demonstrate that the laser therapy is useful for the treatment of bleeding, sessile lesions, small-sized early gastric cancers and malignant strictures induced by advanced cancer.

Adenoma↗
PubMed1987

A new material (single crystal sapphire screw) for internal fixation of the mandibular ramus.

A new single crystal sapphire bone screw which has favourable properties such as chemical stability, mechanical strength and biocompatibility, was applied for rigid internal fixation of the sagittal split osteotomies in 86 cases since 1982. Radiographic findings supported the excellent biocompatibility of the material; there was no noticeable bone loss around the screw and the excellent bone adaptation to the threaded portion was observed. The screws can mechanically support the split mandibular rami until bone union occurs. Complications due to the screw were not encountered in follow-up periods of 0.5-3.5 years.

Aluminum↗
PubMed1987

An ECM substratum allows mouse mesodermal cells isolated from the primitive streak to exhibit motility similar to that inside the embryo and reveals a deficiency in the T/T mutant cells.

The mesodermal cell layer is created by ingression and migration of the cells from the primitive streak region in mouse embryos on day 7 of pregnancy. In order to study the mechanisms of mesodermal cell migration during development, the mesodermal cells isolated from the primitive streak were cultured on various substrata, and cell behaviour and motility were analysed with a time-lapse video system. The mesodermal cells on the surface of extracellular matrix (ECM)-coated dishes (ECM produced by bovine corneal endothelial cells) showed extensive migration at a mean rate of approx. 50 micron h-1. They also showed frequent cell division and exhibited contact paralysis of lamellipodia and contact inhibition of movement. On plastic or glass surfaces, however, the mesodermal cells became more flattened and less motile (approx. 20-30 micron h-1). Cell shape and mean rate of movement on the ECM were very similar to those in situ, as investigated in a previous study (Nakatsuji, Snow & Wylie, 1986). Therefore, this culture condition could provide a useful experimental system for analysing the cellular basis of normal and abnormal morphogenetic movements in mouse embryos. Employing such a culture system, we studied motility of the mesodermal cells from embryos homozygous for Brachyury (T) mutation, which are lethal at the midgestation stage in utero. Histological observations have suggested that anomalous morphogenesis of the T/T embryos may be brought about by defects in migration of the mesodermal cells derived from the primitive streak. When mesodermal cells from the primitive streak of the T/T mutant embryos on days 8-9 were cultured on the ECM substratum, mean rate of cell migration was significantly reduced compared to cells from normal embryos. Results support the idea of retarded migration by the mutant mesodermal cells as an important factor causing abnormalities in morphogenesis.

Animals↗
PubMed1987

Coagulability and fibrinolytic changes during veno-venous bypass in liver transplantation.

In clinical liver transplantation, a venous bypass that rechannels the blood flow from the inferior vena cava and portal vein to the superior vena cava has been used to maintain the venous return. However, the usage of mechanical shunt has given rise to derangements of blood coagulability and fibrinolysis. Therefore, changes of coagulability and fibrinolysis during the venous bypass were examined in dogs using a centrifugal pump (Bio-Pump), and the effect of gabexate mesilate for coagulation were studied. Venous bypass from the inferior vena cava and the portal vein to the external jugular vein was performed in mongrel dogs (group A: bypass without pump, group B: bypass with the Bio-Pump, group C: bypass with the Bio-Pump and the addition of gabexate mesilate). In group A, blood pressure gradually decreased, but in groups B and C it maintained the pre-bypass level. All results of coagulation parameters and fibrinolytic measurements of group B were not significantly different from those of group A; only partial thromboplastin time was prolonged in group B. However, this prolongation was effectively prevented by the addition of gabexate mesilate in group C.

Animals↗
PubMed1987

Multifunctional above-knee prosthesis for stairs' walking.

The multifunctional above-knee prosthesis WLP-7R (Waseda Leg Prosthesis - type 7 Refined) described in this study allows amputees to descend and ascend stairs with no external power sources. With the hydraulic circuit mounted in the shank, the ankle joint and the knee joint mutually conterbalance during stance phase in stair walking as well as level walking so that the following performances are obtained. The yielding (flexing) of the knee joint is prevented and smooth advance from stance-phase to swing-phase is realized in level walking. The gradual yielding of the knee joint and the ankle joint while sustaining full body weight is realized in stair descent. Reciprocal stepping with sound and disabled legs during stair ascent is also realised although the powerful extension of the knee joint during stance phase is not possible. The performance of the WLP-7R was examined by a walking experiment in which amputees could descend and ascend the stairs as well as walk on a flat surface after approximately one hour's training.

Adult↗
PubMed1987

Characterization studies of suppressor cells in murine bone marrow chimaeras.

When BALB/c bone marrow cells were transferred to lethally X-irradiated C3H/He mice either intrasplenically (i.s.) or intravenously (i.v.), suppressor cells were detected by means of MLR coculture assays in the spleen of i.s. and i.v. chimaeras. Some but not all of the suppressor cells expressed a Thy 1.2 antigen, indicating that suppressor cells either sensitive or insensitive to anti-Thy 1.2 antibody plus complement treatment were generated in the spleen of i.s. and i.v. chimaeras. According to the examination of Lyt alloantigen expression on suppressor T cells, Lyt 1+2-, Lyt 1-2+, and Lyt 1+2+ suppressor T cells appeared to be present. The culture supernatants from several T-cell clones showed the suppressor activity against alloreactive MLR. Cell surface markers of these clones were composed of Lyt 1+2-, Lyt 1+2+ and Lyt 1-2+. In addition, since Carrageenan treatment abrogated the suppressor activity of plastic dish adherent cells, we conclude that some of them were composed mainly of macrophages.

Animals↗