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Biomedical subjects

H Friedrich

Publications and source records attributed to H Friedrich.

At least 73 records · Page 4Linked to original sources
PubMed1982

The transcutaneous PO2 measurement as an additional evaluation index to the physiological and pathological conditions under delivery.

Transcutaneous PO2 was continuously recorded from 17 newborns sub partu by normal deliveries and four cases with umbilical cord complications. These data were correlated with the corresponding fetal heart rate alterations and the maximum of contraction directly and 30 s thereafter. During the course of delivery three stages are differentiated: first stage of labor, full cervix dilatation, second stage of labor. The statistical evaluation succeeded in the X2-test (P less than 0.01). Deriving from this result the tcPO2 measurement is an additional aiding procedure beside the cardiotocographic control for subpartal supervision.

Female↗
PubMed1982

Effectivity of oral vaccination of foxes against rabies with Flury HEP strain 675.

A group of 14 adult foxes was orally vaccinated with 2 ml Flury HEP strain 675, titre 10(8.2 TCID50. Each fox seroconverted neutralizing antibody titres ranging between 1:40 and 1:640. These foxes survived an intramuscular challenge with 8000 mouse LD50 pathogenic rabies virus, whereas six out of seven unprotected control foxes died within 28 days. This study was accompanied by virus isolation, fluorescence microscopic examination and neutralization tests.

Administration, Oral↗
PubMed1981

Rehabilitation for patients with multiple sclerosis?

In the epidemiological area of Southern Lower Saxony 92 patients with clinically definite or probable diagnosis of multiple sclerosis (MS) were interviewed and examined. This group contained a remarkably high percentage of benign cases (52%) in comparison with a sample of hospitalized patients. Neurological examination revealed spasticity and pareses to be the most important disturbances followed by ataxia and bladder/bowel problems. After a mean duration of 18.4 years, 52% received a pension and about 30% were still working full time. The pension was granted too early to 11 patients and vocational rehabilitation services would be required for 13 men. Although only half of the patients had an acceptable income, the socioeconomic situation of the families was adequate in 71%; 80% lived with their own families and could stay there in case more ambulant services were offered. Psychotherapeutic measures are required among these to relieve the stress within the families (present in 42%)and to improve the coping behavior (unsatisfactory in 60%).

Disability Evaluation↗
PubMed1980

Purification and characterization of chromatin-bound DNA-dependent RNA polymerase I from parsley (Petroselinum crispum). Influence of nucleoside triphosphates.

The isolation and purification of DNA-dependent RNA polymerase I (EC 2.7.7.6) from parsley (Petroselinum crispum) callus cells grown in suspension culture is described. The enzyme was solubilized from isolated chromatin. Purification was achieved by using DEAE- and phospho-cellulose in batches, followed by column chromatography on DEAE- and phospho-cellulose (two columns) and density-gradient centrifugation. The highly purified enzyme was stable over several months. The properties of purified parsley RNA polymerase I were investigated. Optimum concentration for Mn2+ was 1 mM, and for Mg2+ 4-6 mM, Mn2+ was slightly more stimulatory than Mg2+. The enzyme was most active at low ionic strengths [10-20 mM-(NH4)SO4]. The influence of various phosphates was tested: pyrophosphate inhibited RNA polymerase at low concentrations, whereas orthophosphate had no effect on the enzyme activity. ADP was slightly inhibitory, and AMP had no effect on the enzyme reaction. Nucleoside triphosphates and bivalent cations in equimolar concentrations in the range 4-11 mM did not influence the RNA synthesis in vitro. Free nucleoside triphosphates in excess of this 1:1 ratio inhibited the enzyme activity, unlike free bivalent cations, which stimulated RNA polymerase I.

Cells, Cultured↗
PubMed1980

[Intraoperative doppler sonography of brain vessels (author's transl)].

Intraoperative Doppler-examination of brain vessels. The diagnostic possibilities of the intraoperative Doppler-examination are explained with a few selected cases. This method seems to be helpful for the following purposes: 1. the control of anastomoses, 2. the identification of arteries and veins and their blood flow direction in av-malformations. 3. the determination of the blood flow direction in cerebral veins and sinuses and the decision whether or not a sinus is patent (in parasagittal meningiomas).

Adolescent↗
PubMed1980

[Cerebrospinal fluid (CSF) levels of chloramphenicol: a critical review (author's transl)].

Chloramphenicol was given to four neurosurgical patients intravenously. Serum and cerebrospinal fluid (CSF) concentrations were determined with High-pressure-Liquid-Chromatography (HPLC). A comparison with results reported in the literature shows that in patients without meningitis there is markedly lower concentration of chloramphenicol in the CSF than expected, i.e. it penetrates the "blood-brain" barrier much less easily.

Chloramphenicol↗
PubMed1980

Investigations of cefuroxime levels in cerebrospinal fluid of patients with and without meningitis.

Cefuroxime was given to 5 neurosurgical patients intravenously in intervals of 8 h. Serum and cerebrospinal fluid (CSF) concentrations were determined periodically over severaly days. Our results (72 CSF and serum concentrations) show that cefuroxime penetrates the blood CSF barrier to the same low degree as the previously used cephalosporins. In patients with noninflamed meninges the maximum CSF concentration amounted to 0.09 microgram/ml, in patients with meningitis the maximum concentration amounted to 8.28 micrograms/ml. Although these concentrations were achieved, we would recommend cefuroxime only then, if pathogens isolated from CSF are resistant to chloramphenicol and ampicillin or if patients have a penicillin allergy. Cefuroxime is not a suitable drug for perioperative chemoprophylaxis in neurosurgery as used for certain operations.

Adult↗
PubMed1979

Lack of penetration of cephacetril into the cerebro-spinal fluid of patients without meningitis.

Six neurosurgical patients were given 2-4 g cephacetril intravenously at six hourly intervals. Serum and cerebrospinal fluid (CSF) concentrations were determined. Cephacetril activity was not detectable in the CSF when the blood-CSF barrier was intact. In two patients with increased CSF cell counts cephacetril was found in the CSF in low concentrations (0.1-0.8 mcg/ml). Our investigations show that cephacetril does not penetrate into the CSF unless there is an inflammation or other impairment of the blood-CSF barrier. Thus we could not confirm the results of some authors who found cephacetril in therapeutically effective concentrations in the CSF of healthy persons.

Adolescent↗
PubMed1978

Plexiform neurofibroma (Rankenneurofibrom) of the cauda equina.

The clinical and neuroradiological findings in a rare case of plexiform neurofibroma with bone scintigraphy, myelography and selective spinal angiography are described. The difficulties with the preoperative differential diagnosis from other intraspinal space occupying lesions are discussed and the importance of intraoperative biopsy and electrical stimulation is stressed.

Aged↗
PubMed1978

[Knotted neurinoma or plexiform neurofibroma in the cauda equina (author's transl)].

A rare case of a plexiform neurofibroma in the cauda equina is reported. In literature single cases are described as "redundant or knotted nerve roots", but mainly without microscopic description. Our patient was complained of bilateral pain in the legs for several years. The myelogram revealed a complete block with a serpentine-shaped structure. In operation we found a elongated and redundant nerve root in the cauda equina. The biopsy showed a plexiform neurofribroma. The operative technique is described.

Aged↗