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Biomedical subjects

H Friedrich

Publications and source records attributed to H Friedrich.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Fosfomycin levels in the cerebrospinal fluid of patients with and without meningitis].

18 neurosurgical patients were given 15 g fosfomycin at 8-hour intervals. Simultaneously serum and cerebrospinal fluid (CSF) concentrations were determined periodically over 8 hrs. In patients with noninflamed meninges the CSF-concentrations ranged between 6.48 and 8.98 micrograms/ml. In patients with meningitis the CSF-levels amounted to 20.28 and 39.80 micrograms/ml. For perioperative short-time prophylaxis and postoperative infections in neurosurgical patients therapeutically relevant fosfomycin levels against Staph. aureus und Staph. epidermidis can be achieved.

Adolescent↗
PubMed1986

Extra-intracranial bypass procedure with saphenous vein grafts.

This study reports on 13 cases of extra-intracranial bypass procedures using saphenous vein grafts. Ten patients had arteriosclerotic occlusive vascular disease, one patient had a giant aneurysm of the internal carotid artery, another 2 females, 18 and 28 years of age, respectively, suffered from Takayasu's disease. Preoperatively all patients had severe neurological symptoms. To keep the venous graft as short as possible, as a first choice the carotid artery, in case of occlusive disease of the latter as a second choice the ipsilateral subclavian artery, or as a third choice the ascending aorta, were used as donor vessels. Perioperatively, one patient sustained an intracerebral/intraventricular hemorrhage and, despite immediate reoperation, died in a vegetative state early postoperatively. Another patient had a minor perioperative cerebral stroke with complete recovery. None of the other patients had any additional neurological deficit perioperatively, and they had complete relief from ischemic attacks postoperatively. There was one early occlusion due to high competitive collateral flow, and one late occlusion due to technical problems. The overall patency rate of surviving patients was 83.3% (follow-up 3 to 23 months).

Adolescent↗
PubMed1986

[Modification of intracranial pressure by urapidil following experimental cold lesions in the cat].

The action of the antihypertensive agent Urapidil was investigated in an experimental animal model of vasogenic brain oedema. Animals with normal or raised intracranial pressure received Urapidil as a bolus injection (0.25 mg/kg body weight) followed by a continuous infusion of Urapidil (1 mg/kg body weight). The bolus injection of the drug was followed by a sharp fall in systemic blood pressure, paralleled by a rise in intracranial pressure, resulting in a shortlasting decline of cerebral perfusion pressure. During continuous infusion of Urapidil in both groups with normal or elevated ICP there was a long-lasting significant fall in the systemic blood pressure without any significant alteration of the intracranial pressure.

Animals↗
PubMed1985

[Hyperprolactinemia and prolactinomas. Results of surgical and drug therapy].

185 patients with hyperprolactinaemia and prolactinoma were evaluated in a retrospective investigation. 128 patients were treated surgically whereby the prolactin serum level in 47% of the macroprolactinoma and 60% of the microprolactinoma patients was normalised (prolactin less than 25 ng/ml, no radiological evidence of tumor). Of those patients in whom the operation was less successful, a normal prolactin level could be achieved in 77% by additional therapy with dopamine agonists. Of 57 patients handled exclusively with drugs, the prolactin level was normalised by dopamine agonists in 78%. A small number of patients from both groups did not show a satisfactory fall in the prolactin level despite the use of markedly higher doses of dopamine agonists. During dopamine agonist therapy progressive tumor enlargement was detected radiologically in a previously operated patient.

Adolescent↗
PubMed1985

[NMR and CT studies in acute and late-stage cerebral infarct].

MR offers an additional non-invasive means for the investigation of cerebro-vascular disease. This new digital imaging method competes with CT. Twenty-four patients with cerebral infarcts were examined by CT and MR; of these, 12 were in the acute stage of necrosis and resorption, and 12 were examined after six weeks following the formation of cysts and glial scars. Because of the increased relaxation time of T1 and T2, there is a large signal difference between infarcted and normal brain. Consequently, cerebral infarcts can be clearly recognised during the first 24 hours. MR also has advantages in demonstrating infarcts in the pons and medulla and if one wishes to avoid contrast enhancement during CT. Problems may arise in differentiating fresh infarcts from haemorrhage and from gliomas. At the present time, the length of the procedure and its high cost justify MR in exceptional circumstances only.

Cerebral Infarction↗
PubMed1985

[Comparative studies on early and late operations in aneurysm surgery].

In a five years period from January 1979 to December 1983 241 patients with angiographically verified aneurysms underwent operative treatment in the Department of Neurosurgery at Hannover Medical School. The final results six months after surgery are presented with special regard to the following subjects: preoperative grading (Hunt and Hess scale) and postoperative outcome (Glasgow Outcome Score) timing of surgery: early surgery within 72 hours (88 patients) versus delayed surgery (153 patients) incidence of rebleeding outcome of patients with space occupying intracerebral hemorrhage due to ruptured aneurysms.

Adolescent↗
PubMed1985

[Experiences with selection criteria in myelomeningocele surgery].

Between 1972 und 1983 85 children with myelomeningocele were treated according to the criteria for selective treatment as given by Lorber. The results of children with early or delayed operation and of those who had only supportive care are presented. Survival time and causes of death in the group of children not operated on are in particular given, the sequelae of selective treatment are discussed.

Cerebrospinal Fluid Shunts↗
PubMed1984

[Anamnesis as drama--the first sentences].

The encounter between therapist and patient can be viewed as a drama involving two actors, each attempting to convert the other. This conversion proceeds through unconscious and preconscious elements of interaction whose manifest and latent meaning/definition/interpretation is determined by the manner in which the conflict dynamics evolve within the developmental structure of the anamnesis. In this context one can observe three areas of decisive importance, namely information of an objective, subjective and dramatical nature. An analysis of the opening sentences from two case studies serves to illustrate how the dramatic process is being staged.

Adult↗