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Biomedical subjects

H Frey

Publications and source records attributed to H Frey.

At least 127 records · Page 7Linked to original sources
PubMed1980

A unique case of benign postoperative parotid swelling.

A case of severe, unilateral parotid swelling noted immediately postoperatively is discussed. Review of medical records at three hospitals over the years 1969-1977 failed to reveal similar cases. This unusual entity falls into the spectrum of previously described "anesthesia mumps," and resembles the parotid swelling occasionally noted after peroral endoscopy. This form of perioperative "mumps" is to be clearly differentiated from classic postoperative parotitis and should be recognized as a benign variant requiring no treatment.

Adult↗
PubMed1980

The auto-induction of carbamazepine during long-term therapy.

Healthy male volunteers during regular therapy of carbamazepine had a statistically significant decrease in their plasma drug levels during a period of 28 days. The same phenomenon was also registered in epileptic patients in the course of their long-term monotherapy with carbamazepine. Neither in volunteers nor in epileptics did any statistically significant change in the plasma levels of carbamazepine-10,11-epoxide occur. Wide fluctuations between the fasting and peak plasma level of carbamazepine were found in epileptics. Neither the fasting nor peak plasma levels of the drug correlated in a statistically significant degree with the daily dose of carbamazepine.

Adolescent↗
PubMed1979

Late-onset malignant astrocytoma in a case of multiple sclerosis. Clinical, neuropathological, virological, and tissue culture studies.

An unusual case of concurrent MS and anaplastic astrocytoma is presented. MS was diagnosed in a female patient at the age of 22 years. A left side thalamotomy was performed for relief of severe intention tremor at age 28 and at age 32 she received immunosuppressive therapy for 1 year. At the age of 36 after a severe exacerbation of her symptoms a left side fronto-temporal tumor was diagnosed and a subtotal neurosurgical extirpation was performed. Histopathologically, the tumor was an anaplastic astrocytoma, which was further substantiated by electron microscopy and establishment of a permanent cell line in vitro. The cultured tumor cells were negative for measles virus by immunofluorescence. The relationship between the reactive astrocytes in MS plaques and astrocytic neoplasia is discussed.

Adult↗
PubMed1979

Adherence of multiple sclerosis lymphocytes to measles infected cells.

Adherence of lymphocytes from multiple sclerosis (MS) patients and control subjects to cells persistently infected by measles and control cells was studied. No statistically significant difference between MS patients and controls could be found in this test. Lymphocytes adhered more readily to cells infected by measles than to control cells. The cell to cell contacts are made by the tips of the microvillii of the Lu cells.

Antigens, Viral↗
PubMed1979

Bioavailability of oral testosterone in males.

Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat. Serum testosterone concentration was measured at intervals for up to 6--24 h after the dose. A significant and reproducible rise in serum testosterone level was found after ingestion of free testosterone. Testosterone esterified with undecylenic acid was only effective when administered in arachis oil. The meal increased the bioavailability of the ester, but had hardly any effect on that of the free hormone. It is concluded that bioavailability of oral testosterone can be improved by pharmaceutical means to an extent sufficient to produce adequate blood levels in substitution therapy.

Administration, Oral↗
PubMed1978

Quantitative studies in the cerebral cortex of aging humans.

The capillary network of the human cerebral cortex was morphometrically investigated in a young, aged and aged hypertonic group. In the aging cortex, augmented values of capillary diameter and volume are accompanied by smaller distances between capillaries and an extended length per unit cortex volume. An increased capillary diameter of the aged hypertonic group is probably due to a high blood pressure. The regulating influence of the surrounding astroglia and the extracellular fluid on capillaries seems to lack. In comparison to normotonic brains, higher distances between capillaries and a decreased capillary length were measured.

Adult↗
PubMed1977

Carbamazepine and its 10,11-epoxide in children and adults with epilepsy.

The plasma concentrations of carbamazepine and its 10,11-epoxide were measured in 37 children and 13 adults with epilepsy during maintenance therapy. The children formed relatively more of the epoxy metabolite than adults. The daily dose, expressed as mg/kg or mg/m2, showed a statistically significant correlation with blood level in children, but not in adults. The cerebrospinal fluid concentrations of carbamazepine and carbamazepine-10,11-epoxide in nine children were 33 and 41 per cent, respectively, of the concomitant plasma level.

Adolescent↗
PubMed1977

Antibodies against herpes simplex virus type 1 subunit antigens in patients with trigeminal neuralgia and controls.

Serum IgG antibody levels against herpes simplex virus (HSV) type 1 subunit (capsid, envelope, and excreted) antigens detected with radioimmunoassay were compared in 25 patients with trigeminal neuralgia and their age- and sex-matched controls. No significant differences were found between the patients and controls, either in the distribution of the antibody titers or in the mean titers against any of the subunit antigens tested. In 6 patients HSV antibody titers were tested before and after trigeminal root section; no significant changes were observed.

Adult↗
PubMed1977

Spontaneous and PHA stimulated lymphocyte transformation in multiple sclerosis patients during and after acute exacerbations with special reference to steroid therapy.

Spontaneous (SLT) and phytochemagglutinin (PHA) stimulated lymphocyte transformation was studied in multiple sclerosis (MS) patients suffering from acute exacerbations or from the chronic progressive type of MS. The changes in cell-mediated immunity were also observed before, during and after immunosuppressive (prednisone) treatment. A total of 85 venous blood samples from 23 MS patients (11 males, 12 females) were included in the material. The controls consisted of 25 measurements from 17 healthy volunteers who served as normal controls. The pathological controls consisted of 13 patients with neurological diseases other than MS. All these and MS patients were hospitalized. The IUFdR uptake of the cells of MS patients was more rapid than that of the controls at 1-hr incorporation time in SLT. The difference decreased and was eliminated by longer incubation times (2-4 hrs). MS patients also differed from pathological controls in this sense. The reaction to PHA stimulation was lower both in the MS groups (64 per cent from the normal controls) and in the pathological controls. Within the different MS groups, significantly lower values were seen only in the samples of the patients receiving immunosuppressive therapy. Under prednisone (80-100 mg initial dosis) PHA stimulation values rapidly dropped within the first week and slowly returned within 2-4 weeks after the stopping of the corticosteroid treatment. In some cases, however, PHA values remained at a low level for several months. The significance of this finding for the understanding of the underlying pathogenetic mechanisms has to be studied in more detail.

Female↗