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Biomedical subjects

H C Liu

Publications and source records attributed to H C Liu.

At least 343 records · Page 19Linked to original sources
PubMed1985

The significance of the ratio in follicle-stimulating hormone and luteinizing hormone in induction of multiple follicular growth.

Among the patients enrolled in the Norfolk In Vitro Fertilization Program there were 32 who had been stimulated according to the basic stimulation protocol using two ampules of human menopausal gonadotropin (hMG) daily. Because of their inadequate response, 23 of these 32 patients were stimulated subsequently with a combination of two ampules of "pure" follicle-stimulating hormone (FSH) and two ampules of hMG on cycle days 3 and 4. The remaining nine patients received four ampules of "pure" FSH only on cycle days 3 and 4. Stimulation was continued with hMG in both FSH regimens. Ten thousand units of human chorionic gonadotropin was used for final maturation. Parallel with the increase in the ratio of exogenous FSH to luteinizing hormone, an increase in oocyte recovery was observed, as well as an improvement in transfer and pregnancy rates. It was concluded that FSH enrichment had a beneficial effect in these patients.

Adult↗
PubMed1985

An unusual spinal meningioma in a child: case report.

Meningiomas seldom occur in children, and spinal meningioma in a child is rare. We report the case of a boy, 3 years and 5 months of age, who had an unusual atypical meningioma involving the subarachnoid space from T-2 to the cauda equina. To our knowledge, no similar case has been reported previously.

Child, Preschool↗
PubMed1985

Lymphocyte aberrations in ankylosing spondylitis.

Because the etiology of IgA and IgG hyperimmunoglobulinemia in ankylosing spondylitis (AS) remains unknown, the cellular immune system has been further studied by measuring the lymphocyte and its subpopulations in peripheral bloods of 50 definite AS patients and 40 normal controls. The system's functions have also been assessed in terms of proliferative responses to phytomitogens (Con A, PHA and PWM) and autologous mixed lymphocyte reaction (AMLR). The following results were obtained: The number of lymphocytes, total T, active T, OKIa1, OKT3, OKT4 and OKT8 cells in peripheral bloods of AS patients decreased more significantly when compared to the normal controls. The ratio of OKT4/OKT8 also decreased. However, the number of OKT8 cells was normal in inactive stage. While the lymphocytes of AS responded hyperreactively to PWM (B-cell mitogen), the response to Con A (T-cell mitogen) was depressed significantly. AMLR was impaired in AS patients no matter whether monocytes or B cells were used as stimulators. The aforementioned changes were especially evident in the active stage and most of them returned to normal after the disease became quiescent. It is therefore concluded that the etiology of hyperreactivity of B-cells in AS may be caused by T-cell immune aberration as evidenced by depressed lymphoproliferative response to T-cell mitogen (Con A) and impaired AMLR and/or the hyperfunction of B-cells themselves.

Adult↗
PubMed1984

Painful lumbosacral plexopathy with elevated erythrocyte sedimentation rate: a treatable inflammatory syndrome.

Six patients had a syndrome of painful lumbosacral plexopathy and elevated erythrocyte sedimentation rate. Sural nerve biopsy in each case showed axonal degeneration and epineurial arterioles surrounded by mononuclear inflammatory cells. Differential fascicular involvement suggested an ischemic cause in three nerves, but no patient had a necrotizing vasculitis. None of the six patients had vasculitis or cancer. Three of the six were diabetic and were initially thought to have diabetic plexopathy, but deterioration continued despite control of the diabetes. These six patients appeared to have an ischemic neuropathy with an immunological basis. Five were treated with immunosuppressant drugs, and in four the plexopathy improved or was arrested. The pathogenesis is unclear, but postmortem findings in one case suggest that the syndrome does not stem from an underlying vasculitis.

Aged↗
PubMed1984

Anti-Müllerian hormone is not cytotoxic to human endometrial cancer in tissue culture.

To determine whether anti-Müllerian hormone (AMH) is the factor responsible for the cytotoxic effect of testicular preparations towards endometrial cancer, homogenates and incubation media of bovine fetal testes were fractionated by lectin affinity chromatography on wheat germ agglutinin and their cytotoxic effect tested on an endometrial cancer cell line, HEC-1, and on a control cell line of renal origin. Homogenate-derived testicular proteins proved more cytotoxic than incubation medium-derived ones, and the cytotoxic factor did not bind to the lectin of wheat germ, in contrast to AMH which did. Bioactive AMH purified by monoclonal antibody chromatography, at a concentration, determined by RIA, more than 20 times that present in the cytotoxic testicular preparations, had no effect upon the growth of the malignant endometrial cells. These results indicate that the testicular agent cytotoxic to malignant endometrial cells is a substance other than AMH.

Animals↗
PubMed1984

Early vascular grafting to prevent upper extremity necrosis after electrical burns: II. Experience with wound infection management.

Since May 1972, vein grafts have been used to restore circulation in electrical injuries of the upper extremity when the wrist has been the centre of electrical injury associated with obstructed blood supply. Saphenous vein grafts were used in fifteen limbs in fourteen patients where electrical injuries at the wrist threatened complete loss of the hand. Ten of the hands were free of necrosis with motion basically recovered. The other four cases (five limbs) failed in operation for various reasons, resulting in forearm amputations. Clinical practice showed that successful operations depend upon whether secondary infection is effectively controlled, particularly in those who were brought to the hospital late with wound infection and gangrene of the fingers. This paper reviews the measures for controlling postoperative infections in vascular grafting to restore blood flow at the wrist, and the clinical experience gained in treating these patients (six injured limbs of six cases), and preventing amputation. We hope the method could be improved and its use broadened.

Amputation, Surgical↗
PubMed1984

Immunological aberrations in ankylosing spondylitis patients.

In order to explore the alteration in immunological function in patients with ankylosing spondylitis (AS), serum concentrations of IgG, IgA, IgM, C3 and C4, and lymphocyte subpopulations defined by monoclonal antibodies (OKT series) were studied in 40 AS and 20 age-matched normals. The results showed that i) The IgG and IgA in AS patients were much higher than those in normals (p less than 0.001) and C3, C4 and IgM were also increased (p less than 0.01, less than 0.05, less than 0.05, respectively), ii) The percentage of B cells and OKT3 cells of AS patients were lower, but OKT8 and OKIa1 were higher than that of normals (p less than 0.05). When the AS patients were further divided into active group (22 cases) with c-reaction protein (CRP) higher than, or equal to 15 mg/l and inactive group (18 cases) with CRP less than 15 mg/l, it was found that the inactive group had decreased B cells (p less than 0.01) and OKT3 (p less than 0.05) as compared with normals. On the other hand, the active group had increased percentage of OKT8 than normal controls (p less than 0.05), and increased OKIa1 than both inactive group and normal controls (p less than 0.01), but OKT3 decreased than the normal (p less than 0.05). It is therefore concluded that the immunological aberration plays a role in the pathogenesis of AS.

Adolescent↗
PubMed1983

Microscopic evaluation of the sequential degeneration and repair of the retinae of albino mice after high-dose laser irradiation.

After irradiation of the retinae of albino mice with a dose of 13 J, using a ruby pulse laser, the lesions were followed for a period of 60 days. Severe degenerations were observed in the outer layer 2-9 days after irradiation. By the 21st day after irradiation, the pigment epithelium started to regenerate and outer segments began to reform. Progressive recovery and repair were by and large completed by the 60th day after irradiation.

Animals↗
PubMed1983

The morphology and maturation of the optic tectum of the small shark (Hemiscyllium plagiosum): a morphometrical, ultrastructural and histochemical study.

The morphometrical, ultrastructural and histochemical aspects of the optic tectums of the sharks (Hemiscyllium plagiosum) of different sizes were studied. The 1,000 g animals revealed 2 areas of heavy neuronal concentration. Ultrastructural studies showed an increase in the sizes of tectal neurons and in the sizes of myelinated fibers as well as an increase in the branching system of neurons as the animal matured. A change in the ratio of the types of synaptic contacts was evident in the larger animals. 3 types of glia cells were also observed in these animals. Histochemical studies indicated very little difference between the animals of different sizes except a possible increase of cytochrome oxidase activity.

Animals↗