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Biomedical subjects

H C Liu

Publications and source records attributed to H C Liu.

At least 361 records · Page 20Linked to original sources
PubMed1982

Histochemical studies of fibroblasts from patients with Menkes kinky hair disease and Wilson's disease.

Cultured fibroblasts from Menkes kinky hair disease patients showed markedly reduced succinate dehydrogenase and amine oxidase activities. Cytochrome oxidase activity, however, was greatly reduced in some cells and almost normal in others. Cultured fibroblasts from patients with Wilson's disease showed moderately reduced succinate dehydrogenase and cytochrome oxidase activities. Amine oxidase activity was only slightly reduced when compared to that of normal. These results indicated that the histochemical phenotype observed in fibroblasts from patients with Menkes kinky hair disease and Wilson's disease were distinctly different from each other and from normal fibroblasts.

Amine Oxidase (Copper-Containing)↗
PubMed1982

The natural course of hepatitis B surface antigen-positive chronic active hepatitis in Taiwan.

A prospective study on the natural course of hepatitis B surface antigen (HBsAg)-positive chronic active hepatitis (CAH) in 84 patients was conducted at the Taiwan Veterans General Hospital in Taipei. On presentation, 36% of the patients had jaundice and 94% had elevated serum transaminase activity in addition to clinical symptoms. Of the 84 patients with HBsAg-positive CAH, 76 were followed for an average of 46 months, and at the time of the last visit 46% either had evidence of progressive liver disease or had died. Of the 15 deaths, nine were due to complications of liver disease and six were due to primary hepatocellular carcinoma (PHC), alpha-Fetoprotein levels of greater than 400 ng/ml were found only in patients in whom PHC was detected. The course of HBsAg-positive CAH in this predominantly male Asian population was progressive, and deaths occurred either by liver failure, by bleeding esophageal varices, or by progression to PHC.

Adult↗
PubMed1982

Scanning electron microscopic and histochemical studies of foliate papillae in the rabbit, rat and mouse.

The foliate papillae of the rabbit, rat and mouse were studied by scanning electron microscopy and histochemistry. The papillae consisted of folds and grooves located on the posterolateral margin of the tongue in front of the circumvallate papillae. The numbers of folds and taste buds varied among the three animals species. Scanning electron microscopy showed that in longitudinal sections the taste buds were oval in shape and their pores were surrounded by microvilli. The reaction product of alkaline phosphatase could only be demonstrated in the superficial epithelium of the rabbit as well as in the mouse foliate papillae, but it also diffused into the taste buds in the rat. The intensity and distribution of the reactions of adenosine triphosphatase, acetylcholinesterase and butyrylcholinesterase were identical to those reported by other investigators in spite of differences in animal species and histochemical techniques employed.

Adenosine Triphosphatases↗
PubMed1982

Rupture of a previously unruptured giant middle cerebral artery aneurysm after extracranial-intracranial bypass surgery.

The fatal rupture of a previously unruptured giant middle cerebral artery aneurysm occurred 13 days after an extracranial-intracranial bypass had been carried out, before definitive aneurysm surgery. Alterations in blood flow adjacent to the aneurysm after the bypass may have led to the fatal hemorrhage. After a preliminary extracranial-intracranial bypass procedure, there should be no undue delay in the direct attack on a giant aneurysm, regardless of its mode of presentation.

Cerebral Revascularization↗
PubMed1981

In vitro inhibition of endometrial cancer growth by a neonatal rat testicular secretory product.

The ability of a neonatal testicular product to inhibit cancer cell line growth of Mullerian origin was tested in an "in vitro" system. Preliminary experiments indicated that increasing concentration of neonatal rat testicular homogenates showed increasing endometrial cancer (HEC-1) cell growth inhibition. Further investigation revealed that testes organ culture, similarly, inhibited HEC-1 cell growth. It is, therefore, concluded that neonatal rat testes elaborated a substance (or substances) which may be effective as an anti-tumor agent.

Animals↗
PubMed1981

Stimulation of arylsulfotransferase activity by progestins in human endometrium in vitro.

The effect of progestin on the rate of estradiol (E2) sulfurylation in human endometrium was studied in two culture systems: 1) in intact endometrial tissue fragments and 2) in isolated endometrial epithelial glands and stromal cells. Human endometrial tissue fragments were cultured in medium in the presence and absence of progesterone (P) for 24-48 h. The arylsulfotransferase activity was determined in the cytosol of the tissue homogenate by measuring the rate of conversion of E2 to E2-3 sulfate (E2S) in the presence of an excess amount of substrate and cofactor (adenosine-3'-phosphate-5'-phosphosulfate). The enzyme activity was found to be stimulated in the sample cultured with P. The increase in activity correlated with the dose of P and period of culture. Stimulation of endometrial estradiol dehydrogenase activity by P, which has been reported in a series of previous publications, was also evident in the current study. Human endometrial glandular epithelial and stromal cells were cultured separately in medium in the presence and absence of medroxyprogesterone acetate (MPA). The cultured cells were incubated with E2 (0.4-0.6 nM) for 2 h. The formation of estrogen sulfates, [estrone sulfate (E1S) and E2S] was greatly increased in all the proliferative glandular epithelial cells cultured with MPA. However, the rate of sulfurylation was not appreciably affected by MPA in stromal cells and in glandular epithelial cells from secretory endometrium. The oxidation of E2 in these cultured cells was also influenced by P but not to the extent of sulfurylation. These results indicate that arylsulfotransferase in endometrium originates from glandular epithelial cells and can be stimulated by progestin.

Arylsulfotransferase↗
PubMed1981

Histocompatibility profile in Chinese with ankylosing spondylitis.

Using the two-step microcytotoxicity test as recommended by NIH, U.S.A., 66 Chinese of definite ankylosing spondylitis (AS), 41 their first-degree relatives, and 43 normal Chinese received HLA analysis. The positive rates of HLA-B27 of these 3 groups were 95.5%, 56.1%, and 4.7% respectively. The results indicate: (i) The positive rate of HLA-B27 in patients with AS is significantly higher than their first-degree relatives, or the normal controls. (ii) The high positive rate of HLA-B27 in Chinese with AS is similar to those of other races.

Asian People↗
PubMed1980

Interim follow-up studies of innominate osteotomy for congenital dislocation of the hip.

Innominate osteotomy alone without any adjunctive procedures was performed for congenital dislocation of the hip in 30 children. A complete follow-up study of an average of four years and nine months was obtained for 20 hips in patients. These interim results were quite gratifying. Clinical and radiologic assessments by a score system of Trevor and associates revealed that 85% of the hips that had been operated upon were functionally satisfactory. There were three cases of redislocation which were classified as resulting from technical failures.

Casts, Surgical↗
PubMed1979

Experimental cerebral concussion. A histochemical study.

The activity of mitochondrial enzymes (succinic dehydrogenase and cytochrome oxidase) and enzymes associated with blood-brain barrier function (butyrylcholinesterase and alkaline phosphatase) in the CNS of rats was studied from 5 minutes to 62 hours after cerebral concussion. There was a transient increase in succinic dehydrogenase activity during the first hour after concussion in the neurons of the structures close to the impact. The alkaline phosphatase activity, strongly positive in the walls of normal blood vessels, decreased within five minutes after concussion; it virtually disappeared in 15 minutes but returned to normal level after 62 hours. These findings are in good correlation with previous electron microscopic observations. Their significance is discussed.

Alkaline Phosphatase↗