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Biomedical subjects

H Bernhardt

Publications and source records attributed to H Bernhardt.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Use of metronidazole in treatment of postoperative obstetric infections (author's transl)].

Thirteen patients with abscess of the abdominal wall, including one case of endomyometritis following caesarean section, received metronidazole treatment (Vagimid), on the first two days of therapeutic action. The dosage was 500 mg twice per days, some of the applications combined with antibiotics. Proper healing was achieved in the majority of the cases. Clinical symptoms improved very soon, and hospitalisation could be shortened. Metronidazole was well tolerated. Microbiological tests were undertaken, and gas chromatography was used to establish from pus anaerobic metabolic products.

Abscess↗
PubMed1980

[Diagnosis and therapy of endomycoses].

According to the increase of mycoses of mucous membranes and organs which are to be observed all over the world their pathogenic agents are described in a survey. In pathogenesis the above all endogenic infections are the dominant factor. A series of laboratory-diagnostic methods, particularly quantitative cultural and serological methods, are valuated in their evidence. In the clinical diagnostics the symptomatology of the individual organ manifestations and the endoscopic bioptical methods are particularly emphasized. The dominant factor in the features of the antimycotic therapy lies in the newer antimycotics, including the necessity of a permanent control of the position of pathogenic agents and resistance.

Antifungal Agents↗
PubMed1980

Endoscopic aspects of mycosis in the upper digestive tract.

In an evaluation of 2537 endoscopic investigations of the upper digestive tract, yeast-like fungi were found in cultures from 53 purposive brushings (2.1%) obtained from visible mycotic areas. In 46 cases the esophagus only was affected. In the stomach and surrounding the anastomosis after resection, we found 6 positive results. Once, findings were seen in the esophagus as well as in the stomach. Determination of the yeast-like fungi revealed Candida albicans in 43 cases. Other fungi were cultured 18 times, among them Torulopsis glabrata 3 times. In every mycosis culture it is useful to determine the species of yeast-like fungi and the drug sensitivity. Every mycosis should be assessed endoscopically with regard to its degree of severity. Endoscopy is a very important method for the diagnosis of gastrointestinal mycosis. The investigation of more easily obtainable specimens such as throat swabs or feces, may often be of no use.

Candida↗
PubMed1980

[Endotoxinaemia in liver cirrhosis (author's transl)].

23 patients with liver cirrhosis of diverse etiology and of different activity levels and grades of compensation of the portal circulation were examined with regard to the systemic endotoxinaemia. The endotoxin was determined using the Limulus-Amoebocyte-Lysat-test. Endotoxin was traceable in the venous blood of 7 out of 23 patients (= 30,4%). No relation was found between endotoxaemia and the activity or grade of severity of liver cirrhosis; nor were there any accumulation of endotoxinaemia in patients with collateral circulation or portal decompensation. Consequently, as a result of our findings, the prognostic value of the symptom endotoxinaemia remains debatable, then endotoxinaemia does not always mean endotoxicosis. Particularly high immunoglobulin concentration and low albumin values in serum of endotoxin-positive cirrhotics indicate a "spillovet" of antigen substances and also of endotoxines in the body circulation resulting from insufficiency of the liver-RHS. Parallel analysis of microbian small bowel flora in 10 patients indicate that coli-dysbiosis appears to play a role in the development of systemic endoxinaemia, although the latter was also traceable in borderline cases of eubiosis/dysbiosis. Our findings strengthen the view that it is not possible to simply translate the findings in animals on to human liver diseases. Quite a number of the mechanisms being discussed are still with uncleared details and they give only a blurred picture of the pathophysiology of endotoxinaemia.

Adult↗