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Biomedical subjects

H Bauer

Publications and source records attributed to H Bauer.

At least 307 records · Page 17Linked to original sources
PubMed1978

[Suprapubic bladder drainage in the surgical patient (author's transl)].

Suprapubic bladder drainage is today a safe method of urine deviation. Outflow obstruction after lesions or operations in the uro-genitary system is the main indication for suprapubic drainage. The best indications therefore exist in urological and gynaecological patients. We used suprapubic bladder drainage in 20 patients after general surgery, applying a catheter set (Cystofix) with removable split cannula. There were no serious complications. Urine cultures in 6 patients controlled 6 days after insertion of the catheter were negative. Suprapubic bladder drainage using suitable catheter sets, can be recommended in patients without outflow obstruction, especially in intensive care.

Adult↗
PubMed1977

Avian retrovirus-induced surface antigens and their cross-reactivity with chemically-transformed cells and primary embryonic cells of Japanese quails.

By testing spleen cells from avian leukosis (ALV) and avian sarcoma virus (ASV)-injected Japanese quails in a microcytotoxicity assay against various target cells, we have demonstrated the existence of several target antigens. With non-transformed ALV-infected Japanese quail cells used as target cells, an avian retrovirus subgroup-specific destruction was obtained when spleen cells from animals infected with either avaian sarcoma or leukosis virus of the same subgroup were employed. This reaction is probably due to the virus envelope glycoproteins (Ve-gp) expressed on the cell surface. Apart from this subgroup-specific reaction, avian retrovirus group-specific destruction of ASV-transformed cells was demonstrated by means of effector cells immunized with ASV of a different subgroup. This reaction is restricted to transformed cells and not due to the virus envelope glycoprotein because the same effector cells are not cytotoxic to ALV-infected non-transformed cells but cytotoxic to sarcoma-virus-transformed cells which lack Ve-gp. Quail methylcholanthrene-tumor cells which show a transformation phenotype similar to that of ASV-transformed cells but which are free of detectable endogenous and exogenous retrovirus were also destroyed by the spleen cells from ASV tumorbearing animals. The same effector cells also exerted a weak cytotoxic effect on uninfected primary embryo cells but not to embryo cells after several passages.

Alpharetrovirus↗
PubMed1977

Protein profile of cerebrospinal fluid in multiple sclerosis with special reference to the function of the blood brain barrier.

The leucocyte count, total protein, albumin, IgG, IgA and IgM content of the cerebrospinal fluid (CSF) of 103 multiple sclerosis (MS) patients was determined. In 54 cases a simultaneous analysis of serum was also carried out. As a sign of an intact blood brain barrier the albumin concentration was normal in 76.7%. Taking into account the relative IgG quotient in CSF and serum, and the albumin and IgG concentration gradients between CSF and serum, it was possible to reveal an elevation of IgG content in CSF of MS patients in 75 and 83%, respectively. Without a simultaneous analysis of serum this was the case only in 51.5%. In MS cases with an intact blood brain barrier the values for IgA and/or IgM were slightly elevated in 11.7%. This study demonstrates analytic methods, which support the hypothesis of IgG synthesis by cells accumulating within the CNS in MS. A correlation of the laboratory results and clinical manifestation of MS was tried.

Adult↗
PubMed1977

Olfactory sarcoidosis. Report of five cases and review of the literature.

Changes in the olfactory system in five patients with sarcoidosis were studied by clinical and histopathological examination. Every patient studied had hypogeusia and/or hyposmia as measured by psychophysical testing. In two patients who died with this disease, the olfactory bulbs and tracts were involved by granulomatous infiltration. Two other patients showed granulomas and chronic inflammation in nasal biopsy specimens. The fifth patient was studied only clinically. Changes in olfactory and gustatory acuity are rarely searched for in patients with sarcoidosis, but they may be important indicators of major and later irreversible damage to the CNS. If diminished olfaction is established in suspect patients, nasal biopsy and examination of the CNS should be performed to confirm the presence of active sarcoidosis. Appropriate therapy may prevent damage to the patient's sensory capabilities and CNS function.

Adolescent↗
PubMed1977

Impairment of vigilance and performance under lithium-treatment. Studies in patients and normal volunteers.

Subtle changes of adaptive behaviour under lithium treatment may possess interest not only as side-effects, but also as a possible explanation for the mechanism of action of lithium salts. - In 18 patients under long-term lithium treatment and 10 normal volunteers before and after one week of lithium application the EEG was recorded and performance as well as psychophysiological tests were carried out. The results, particularly of the d-2-test point to a considerably reduced performance in patients and normal volunteers. The EEG data in both groups suggest reduced vigilance until stage B3 or C (in the sense of Head of Bente); CFF was significantly elevated only during the first days of lithium application in the normal volunteers. Whereas EEG changes persist, other symptoms as CFF reduction, fine hand tremor, or reduced performance resolved at least partially 7 days after lithium withdrawal in the normal volunteers.

Adult↗
PubMed1977

Influence of defective virion core proteins on RNA maturation with an avian sarcoma virus.

The RNA of the avian sarcoma virus B77 temperature-sensitive mutant LA334 was investigated using electrophoretic analysis. The RNA from mutant virus grown at the nonpermissive temperature (42degrees C) showed a heterogeneous peak between 80 and 125S, and another at about 35S. The RNA of the mutant virus grown at the permissive temperature (35 degrees C) behaved like wild-type B77 virus RNA, exhibiting a major peak at 70S. The homology between the various RNA fractions and virus-specific DNA probe was determined, indicating that mutant virus grown at the nonpermissive temperature contains relatively large amounts of nonviral-specific RNA.

Avian Sarcoma Viruses↗
PubMed1977

Distinguishable transformation-defective phenotypes among temperature-sensitive mutants of Rous sarcoma virus.

Eight transformation-defective, temperature-sensitive (ts) mutants of the Prague strain of Rous sarcoma virus, subgroup A, have been isolated after mutagenesis with 5-bromodeoxyuridine followed by selection on the basis of focus tests. Five of these mutants, ts GI201, GI202, GI203, GI204, and GI205, exhibit properties like most previously reported isolates in that they show a temperature-sensitive response to each of a variety of transformation-specific parameters tested. Interestingly, GI201, in addition to the temperature-sensitive defect, carries a lesion that was observed as a nonconditional loss of expression of plasminogen activator protease. Three mutants, ts GI251, GI252, and GI253 have been disignated partial transformation-defective (PTD) mutants since they behave as ts mutants according to some tests for transformation and as wild type according to others. These three mutants fail to form foci at the nonpermissive temperature (41 degrees C) and art nontumorigenic in 3-week-old chickens (body temperature, 42 degrees C). The agglutinability by concanavalin A of cells infected with these mutants shows a definite temperature sensitivity, as do the rate of 2-deoxyglucose uptake and the disappearance of the 250, 000-dalton normal cell glycoprotein (large, external, transformation sensitive [LETS]). Although the PTD mutant-infected cells, unlike cells infected with other transformation mutants, exhibit a cell-bound plasminogen activator protease at the nonpermissive temperature, this activator is not detectable as a free protease in the medium, as it is with wild-type, virus-infected cells. The PTD mutants behave like the wild-type parent in their ability to induce transformed growth properties in the infected cells, i.e., growth beyond normal cell saturation density with or without serum-supplemented medium and growth leading to colony formation in soft-agar- or methyl cellulose-containing suspension media.

Agglutination↗
PubMed1977

Cross-neutralization of ovine and bovine C-type leukemia virus-induced syncytia formation.

Ovine leukemia virus (OLV) could not be distinguished from bovine leukemia virus (BLV) morphologically. Both C-type RNA tumor virus-producing cells induced syncytia when cocultivated with several indicator cells including XC and KC cells. Syncytia formation could be blocked by antibodies against OLV and BLV, indicating that fusion was virus mediated. Furthermore, antibodies against OLV and BLV exhibited reciprocal syncytial blocking properties, suggesting that OLV and BLV were closely related viruses.

Cell Fusion↗
PubMed1977

[Prevention and treatment of upper gastrointestinal haemorrhage with cimetidine and somatostatin in intensiv care patients (author's transl)].

Upper gastrointestinal haemorrhage is a severe problem in patients in surgical intensive care units. Good experimental and clinical results are reported with somatostatin (somatotropin release inhibitoring factor) and cimetidine (H2-receptor antagonist) in prevention and treatment of acute gastrointestinal bleeding, by blocking gastric acid secretion. These experiences are confirmed with an open trial in 13 seriously ill surgical patients. First of all cimetidine can be recommended because of its mode of action and application.

Adult↗
PubMed1977

[The Schwartz-Jampel syndrome (myotonia chondrodystrophica)].

Report on three siblings with typical features of Schwartz-Jampel's syndrome which is transmitted by a rare autosomal recessive gene: odd facies, stiff posture, high pitched voice, myotonic reaction, Perthes-like dysplasia of the femoral head. Biochemical and histological findings are minimal and nonspecific.

Abnormalities, Multiple↗