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Biomedical subjects

H Andersson

Publications and source records attributed to H Andersson.

At least 145 records · Page 8Linked to original sources
PubMed1988

Dietary intake before and after gastric bypass and gastroplasty for morbid obesity in women.

Fifty-one morbidly obese women were randomized to surgical treatment with gastric bypass (GBY) or gastroplasty (GPL). Their dietary intake was assessed preoperatively and 12 months postoperatively by two methods: diet history and 4-day weighted intake. Their protein intake was also checked against urinary nitrogen losses. There was a good correspondence between the results of the two dietary methods and also between estimated protein intake and urinary loss. This makes the results reliable. After 1 year the GBY patients demonstrated a mean weight loss of 41.6 +/- 10.8 kg (P less than 0.001 versus GPL) and a mean energy intake preoperatively of about 2400 kcal/day and postoperatively of 1050 kcal/day (P less than 0.05 versus GPL). The GPL patients lost 28.9 +/- 9.6 kg as a mean and had a preoperative intake of about 2500 kcal/day and a postoperative intake of about 1300 kcal/day. There were only minor changes in the quality of the food from the preoperative to the postoperative situation. Postoperatively the daily intake of several nutrients was below minimum values of recommended or required intake.

Adult↗
PubMed1987

Degradation products of bran phytate formed during digestion in the human small intestine: effect of extrusion cooking on digestibility.

To investigate the digestion of phytate in the stomach and small intestine in humans, studies were performed in subjects with established ileostomy. A recently developed high performance liquid chromatography method made it possible to analyze phytate and its degradation products in food and digesta. The digestibility of phytate in raw bran and extruded bran was investigated in seven ileostomy patients. Each subject was studied for two 4-d periods while consuming a constant low fiber diet with the addition of either 54 g/d of a bran-gluten-starch mixture or the corresponding extruded product. During passage through the subject's stomach and small intestine 58%, on average, of the phytate in unprocessed bran was hydrolyzed to inositol penta-, tetra- and triphosphates. When bran was subjected to extrusion cooking, 25% of the inositol hexaphosphate was hydrolyzed to penta- and tetraphosphate and the phytase activity ceased. Essentially no phytate digestion occurred when the ileostomy subjects consumed the extruded product. The reduced digestibility might be due to the lost phytase activity or to formation of indigestible phytate complexes during extrusion cooking.

Cooking↗
PubMed1987

Cholelithiasis and urolithiasis in Crohn's disease.

In a consecutive series of 107 patients operated on for Crohn's disease involving the distal ileum, the overall incidence of gallstones was 17% and of renal stones 12%. Whereas the frequency of gallstone disease was 9% in patients with minor resections, patients with more than 100 cm diseased or resected small bowel had a frequency of 35%. The probability of gallstone development in both sexes was calculated to be approximately 50% after 20 years of distal ileopathy. The frequency of renal stone disease in patients with minor resection was comparable to that of a population in Sweden but was significantly commoner in patients with resection of more than 100 cm (28%), provided they were not colectomized. The high frequency of stone disease after resection of distal ileum is attributed to metabolic disturbances due to steatorrhea and bile salt malabsorption.

Cholelithiasis↗
PubMed1987

Relationship of dietary gluten intake to dapsone dose in dermatitis herpetiformis.

The gluten intake was quantitated utilizing a dietary history method in 43 patients with dermatitis herpetiformis on non-restricted diet. The mean daily gluten intake was 15 g. The individual intake of gluten was related to the maintenance dose of dapsone. It was significantly higher in patients on 100-150 mg dapsone daily than in those taking 0-25 mg daily. There was a significant correlation between amount of gluten in the diet and the dapsone dose (p less than 0.01, rs = 0.43). Villous atrophy was not related to the dapsone dose. It is suggested that the gluten-sensitive enteropathy changes the intestinal permeability and thus contributes to the development of blisters.

Adolescent↗
PubMed1986

On a free autologous graft of the greater omentum for spinal CSF drainage.

A pedicular flap of the greater omentum can after transposition through the posterior abdominal wall to the lumbar subarachnoid space resorb cerebrospinal fluid (CSF), according to earlier studies. The present study investigates the basic prerequisites in rats and cats for a simplification of the method, utilizing a free omental graft transplanted to the lumbar or cervical region, in contact with neighbouring sacrospinal muscles. It is concluded from long term studies that the free omental graft "survives" and preserves its histological characteristics by revascularization between muscle and omentum, indicating a useful resorptive function.

Animals↗
PubMed1986

Extrusion cooking of a high-fibre cereal product. 1. Effects on digestibility and absorption of protein, fat, starch, dietary fibre and phytate in the small intestine.

1. The effect of extrusion cooking of a high-fibre cereal product on digestibility of starch, fibre components and phytate in the stomach and small intestine was studied by in vivo digestion in ileostomy subjects, as well as its effect on ileostomy losses of fat, nitrogen, sodium and potassium. 2. Seven ileostomy subjects were studied during two periods (each of 4 d) while on a constant low-fibre diet supplemented with 54 g/d of a bran-gluten-starch mixture (period A) or the corresponding extruded product (period B). 3. Extrusion cooking, using mild conditions, did not change the content of starch, dietary fibre components or phytate of the bran product, but the phytase (EC 3.1.3.26) activity was lost. During the period using the extruded bran product, there was a significant increase in recovery of phytate-phosphorus (period A, 44% of intake; period B, 73% of intake). The amount of fibre components, fat, fatty acids, N, Na, K, water and the ash weight of the ileostomy contents did not differ between the two periods. Only 0.6 and 0.7% respectively of ingested starch was recovered in ileostomy contents in periods A and B, while the fibre components were almost completely recovered. 4. Extrusion cooking, using even mild conditions, may lead to a considerable impairment in the digestion of phytate, probably due to a qualitative change in phytate and a loss of phytase activity. Starch, before and after extrusion cooking, is almost completely digested in the stomach and small intestine while fibre components are digested to a very small extent.

Absorption↗
PubMed1986

Extrusion cooking of a high-fibre cereal product. 2. Effects on apparent absorption of zinc, iron, calcium, magnesium and phosphorus in humans.

1. The effect of extrusion cooking, using mild conditions, of a high-fibre cereal product on apparent small bowel absorption of zinc, iron, calcium, magnesium and phosphorus was studied. 2. Seven ileostomy subjects were studied during two periods (each of 4 d), on a constant low-fibre diet supplemented with either 54 g/d of a bran-gluten-starch mixture or the corresponding extruded product. 3. The apparent absorption of Zn, Mg and P was significantly decreased (P less than 0.05) during the period with extruded product compared with the period with bran-gluten-starch. No difference was found for Fe and Ca. 4. The negative effect of extrusion cooking of a product containing phytic acid on availability of Zn, Mg and P was small but could be of nutritional relevance in foodstuffs that are consumed frequently and in infant formulas.

Absorption↗
PubMed1986

Balance studies in patients with intestinal resection: how long is enough?

1. Results from two independent metabolic balance studies in patients with ileal resection with or without a remaining colon were examined to assess the precision of the mineral, protein and fat balances obtained. 2. Low day-to-day variation in balances was found in patients with ileostomy/jejunostomy, irrespective of formula diet composition. In contrast, patients with a remaining colon showed considerable variation, with reliable cumulative balances often not reached for many weeks. 3. In conclusion, short-term cumulative balances can be performed with good precision in patients with ileostomy or jejunostomy.

Colectomy↗
PubMed1986

Dietary habits in relation to incidence of cardiovascular disease and death in women: a 12-year follow-up of participants in the population study of women in Gothenburg, Sweden.

Dietary intake as initially estimated by means of a 24-h recall has been related to the incidence of ischemic heart disease, stroke, and overall mortality during a 12-yr follow-up period in a prospective study of 1462 women representative of the general population. Energy intake was inversely correlated to the 12-yr incidence of myocardial infarction. The correlation was independent of age, indices of obesity, smoking habits, serum cholesterol, serum triglycerides, diabetes, systolic blood pressure, and physical activity. No correlation was found between dietary intake and incidence of stroke or overall mortality, nor was any correlation found between end-points and intake of fish, energy percentage of fat, protein, and carbohydrates. These observations suggest that suboptimal intake of nutrients may be an important factor in the pathogenesis of ischemic heart disease.

Adult↗
PubMed1986

Retention of zinc and calcium from the human colon.

Colonic retention of zinc and calcium was studied after installation during colonoscopy of 30 mumol of zinc and 6.4 mmol of calcium labeled with 65Zn and 47Ca, and measurement of the whole-body retention of the radionuclides. After cecal installation in nine patients, retention (day 13) of zinc was 3.5 +/- 2.1% (mean +/- SD) and of calcium 3.5 +/- 2.7%. The calculated mean absorption was 4.1% for zinc and 14.1% for calcium. Application at the hepatic flexure in four patients resulted in a mean retention (day 13) of 1.2% for zinc and 0.6% for calcium. Under prevailing conditions, colonic absorption of zinc is relatively small, compared to the uptake after oral administration. Colonic absorption of calcium could, however, account for a substantial part of the total calcium uptake.

Aged↗
PubMed1986

Apparent small intestinal absorption of nitrogen and minerals from soy and meat-protein-based diets. A study on human ileostomy subjects.

The apparent absorption of nitrogen and minerals was studied in 8 ileostomy subjects. Four different test diets containing 60 g of meat, rice and bread protein, or a 25% replacement of the protein with soy flour, soy concentrate or soy isolate, were randomly assigned to the subjects in 2-d periods. All animal protein was replaced by soy isolate for a fifth 2-d period in two of the subjects. Ileostomy contents were collected in 2-h intervals during the day and in one portion during night and immediately deep-frozen. The fiber components and the phytic acid in the diet were almost completely recovered in the ileostomy contents, whereas unabsorbed starch was less than 2% of the intake. A significantly lower protein digestibility was observed when the diets containing soy protein were fed. No difference in protein digestibility was found between the different soy protein products. A 25% replacement by soy protein had no obvious effect on apparent mineral absorption. A low protein digestibility was also observed when soy was the main source of protein, and a negative apparent absorption of zinc was found in both subjects. Although 25% of soy protein in the diet does not seem to impair mineral absorption significantly, small intestinal net absorption of nitrogen is less from the soy diets than from the meat diet.

Adult↗
PubMed1986

Normal pressure hydrocephalus. Predictive value of the cerebrospinal fluid tap-test.

Twenty-seven patients with normal pressure hydrocephalus were operated upon by a ventriculo-peritoneal shunt. Selection for shunt surgery was based on typical symptoms (gait disturbancy, mental deterioration and urgency incontinence) and characteristic changes at cranial computed tomography and/or radionuclide cisternography. Prior to operation a cerebrospinal fluid tap-test (CSF-TT) was performed with measurements of psychometric functions and gait pattern before and after a lumbar puncture of 50 cc CSF. Nineteen patients improved and 5 were unchanged after shunt operation. Three patients could not be evaluated. Improvement in the psychometric functions and gait pattern after lumbar puncture correlated to improvement after the shunt operation (r = 0.64, p less than 0.01: r = 0.96, p less than 0.001, respectively). Improvement in 2 or more of the 4 tests used (3 psychometric and 1 gait test) at CSF-TT implied in all cases successful result of the shunt operation. It was concluded that CSF-TT could predict which NPH patient will improve by a shunt operation, and albeit to envisage the degree of improvement.

Adult↗
PubMed1986

Effects of hay-feeding on acid/base balance, renal sodium excretion, aldosterone and vasopressin secretion in the goat.

Effects of 30 min intense hay-feeding on acid/base and sodium homeostasis were studied in semi-starved goats during hyper- and euhydration. Parallel analyses of carotid and jugular blood samples revealed that feeding induced metabolic acidosis, which to some extent was subjected to respiratory compensation. The acidosis was accompanied by renal sodium retention and urinary acidification persisting for 2-3 h. The sodium retention was succeeded by an increase in renal Na excretion above the initial level. This natriuresis was most accentuated during hyperhydration. Blood samples taken for hormone assays during euhydration revealed a 15% increase in haematocrit and a significant rise in plasma aldosterone at termination of feeding. Inhibition of the water diuresis in hyperhydrated animals, and moderate increases in renal arginine vasopressin (AVP) excretion and plasma AVP were inconsistent effects of feeding. It is concluded, that simply jugular vein blood provides reliable information on the acid/base status of goats, but that the feeding schedule has to be considered in all experiments where small ruminants are used to investigate the integrated control of acid/base and sodium homeostasis.

Acid-Base Equilibrium↗
PubMed1986

Influence of heat exposure on acid/base and fluid balance in hyperhydrated goats.

Hyperhydrated goats were exposed to an environmental temperature of 45 degrees C (relative humidity 70%) for 120 min. After 90 min, rectal temperature and respiratory frequency reached plateau levels of 40.5 degrees C and 280 respirations min-1, respectively. Measurements of arterial and venous blood acid-base parameters revealed that respiratory alkalosis had started to develop after 60 min, and had become obvious at the end of the heat exposure period. Renal compensation (evidenced by gradual increases in urinary pH and renal Na excretion) developed in parallel with the respiratory alkalosis. The heat exposure elicited a moderate, temporary inhibition of the water diuresis, but no obvious increase in the renal excretion of arginine vasopressin (antidiuretic hormone, ADH). Preliminary determinations of plasma aldosterone did not show any change during the actual heat exposure period, but a 50% temporary decrease in plasma aldosterone 30 min thereafter. The study confirms the susceptibility of goats to develop respiratory alkalosis during thermoregulatory panting, and shows that this is not to any appreciable extent diminished during hyperhydration. It can further be concluded that a heat-induced rise in body temperature to 40.5 degrees C is no powerful stimulus for vasopressin release in the hyperhydrated goat. The determinations of plasma aldosterone suggest that reduced liberation of the hormone does not contribute to the immediate renal compensation of respiratory alkalosis, but that respiratory alkalosis reaching a certain intensity inhibits aldosterone secretion.

Acid-Base Equilibrium↗
PubMed1986

A double-blind randomized comparison of the effect and tolerance of Varidase versus saline when instilled in the urinary bladder in patients with catheter problems.

Thirty-eight patients with problems with their urinary catheters were randomly treated with Varidase or normal saline solution once a day for 10 days. Photographs were taken by using a cystoscope before treatment, at day 10 and day 24 after the commencement of treatment. The photographs were evaluated according to the occurrence of pus, debris, coagula and rubor. In the Varidase group the improvements from baseline to day 10 and day 24 were statistically significant (p less than 0.05) in all parameters while there were no statistically significant improvements in the saline group. Comparing the two treatment groups, regarding the changes from baseline to day 10 and day 24, it was statistically demonstrated that Varidase was significantly more effective than saline in all parameters (p less than 0.05). In conclusion, this study shows that Varidase effectively cleans the urinary bladder from pus, fibrin, necrotic tissue and blood clots.

Aged↗
PubMed1986

Low-fat versus medium-fat enteral diets. Effects on bile salt excretion in jejunostomy patients.

Nine jejunostomy patients were given three low-residue enteral diets in random order through a nasogastric tube. Total bile salt excretion in the jejunostomy contents was 13-17% lower (p less than 0.05) on low-fat diets than on a medium-fat diet. Cholate excretion was 14-20% lower, but chenodeoxycholate excretion showed no difference on the low-fat diets. The study supports the idea of a lower excretion of bile salts to the colon as an explanation of reduced diarrhoea when a low-fat diet is prescribed to patients after ileal resection.

Adult↗