Search PubMed⌕ Search

Biomedical subjects

H Andersson

Publications and source records attributed to H Andersson.

At least 127 records · Page 7Linked to original sources
PubMed1990

Truncal vagotomy reduces food and liquid intake in man.

Truncal vagotomy reduces food and liquid intake in laboratory animals but has not been studied in man. Seven (6F) morbidly obese patients kept 4-day dietary diaries with validation by urine nitrogen analysis before and 3 and 9 months after truncal vagotomy without drainage. Significant reductions in body weight were accompanied by reductions in self-reported total calorie intake from 2800 kcal/day to 1800 at 3 months and 2000 kcal/day at 9 months. The correlation between reported and validated protein intake was .72 (p less than 0.001) with a mean underreporting of protein intake by at least 27%. Macronutricant postoperative reductions in total volume and calorie density of liquid intake. Liquid calories were reduced by 47% at 3 months and 50% at 9 months and solid calories by 33% at 3 months and 27% at 9 months. It is concluded that truncal vagotomy reduces food and liquid intake in man preferentially through liquid reduction. These results have implications for surgical treatment of morbid obesity.

Adolescent↗
PubMed1990

Serum lipoproteins in day and shift workers: a prospective study.

This study was designed to assess changes in diet and serum lipoproteins in shift workers. Twelve shift workers and 13 day workers were examined before employment and after six months at work. Total cholesterol and serum triglycerides did not change significantly. In both groups a decrease in systolic blood pressure was observed. The ratio between apoB and apoA-1 lipoproteins increased by 18% in shift workers compared with 5% in day workers. The change in the ratio between apoB and apoA-1 lipoproteins showed a significant inverse correlation with the change in intake of dietary fibres.

Adult↗
PubMed1990

Nutrients excreted in ileostomy effluents after consumption of mixed diets with beans or potatoes. II. Starch, dietary fibre and sugars.

The extent of carbohydrate digestion and absorption from two diets including either instant bean flakes (174 g/d) or potato flakes (102 g/d) was measured in seven ileostomy subjects during a 2-day period. Test foods contributed 40 per cent of the total dietary starch intake (160 g/d), the remainder coming from rice and white bread. Overall, 4 per cent and 0.7 per cent of the dietary starch consumed remained unabsorbed during the bean and potato periods, respectively. Between 9.0 and 10.9 per cent of dietary bean starch and less than 1.7 per cent of potato starch were not absorbed. Dietary fibre and resistant starch were completely recovered in ileostomy effluents. In separate meal tests with 40 g starch, beans gave lower blood glucose (P less than 0.05) and serum insulin (P less than 0.01) responses than potatoes. Dietary starch malabsorption from leguminous foods is less than previously estimated and does not explain the attenuated glycaemic and insulinaemic responses.

Adult↗
PubMed1990

Nutrients excreted in ileostomy effluents after consumption of mixed diets with beans or potatoes. I. Minerals, protein, fat and energy.

The small intestinal excretion of protein, fat, energy, magnesium, calcium, iron and zinc from two isocaloric diets including either instant bean flakes (174 g/d) or potato flakes (102 g/d) was studied in seven ileostomy subjects. Out of the variable part of the diet all starch and dietary fibre, and about half of the energy was provided from bean flakes or potato flakes, respectively. The small variation in ileostomy excretion between two consecutive days, after one adaptation day, suggests that ileostomy studies can be performed with reasonable precision in 2 days. During the 2-day potato period average daily excretions of gross energy and protein were 236 kcal (988 kJ; 11 per cent of intake) and 13 g (12 per cent), respectively. The excretions were significantly (P less than 0.001) higher during the bean period, 378 kcal (1582 kJ; 16 per cent) and 17 g (15 per cent). Fat intake and excretion were not different. After making allowance for dietary fibre, the apparent nutrient energy digestibilities were over 90 per cent, with only 43 kcal (180 kJ; 2 per cent) difference between the two periods. Apparent absorption of magnesium was lower during the bean period, 7 per cent compared to 25 per cent (P less than 0.02). The study has thus shown that only slightly less apparent small intestinal absorption occurs from a diet with bean flakes compared to potato flakes, so the nutritional consequences of beans on other nutrients seem to be small.

Adult↗
PubMed1990

Effect of inositol hexaphosphate on retention of zinc and calcium from the human colon.

Colonic retention of zinc and calcium was studied after installation during colonoscopy in 11 patients of a solution of 30 mumol zinc, 6.4 mmol calcium and 500 mumol inositol hexaphosphate (phytic acid) labelled with 65Zn and 47Ca. Whole-body retention of the radionuclide at day 13 was 1.0 +/- 1.0 per cent (mean +/- s.d.) for zinc and 4.0 +/- 2.9 per cent for calcium. The retention of zinc but not of calcium was lower than observed earlier under similar conditions from a solution not containing phytic acid and indicates formation of an indigestible complex between phytic acid and zinc. Addition of amino acids to the solution in 3 subjects did not seem to affect the retention of zinc and calcium.

Adult↗
PubMed1990

Alterations in body composition after gastroplasty for morbid obesity.

Body compositional changes during rapid weight loss and after weight stabilization were prospectively studied in morbidly obese patients undergoing gastroplasty operations. Body composition was studied preoperatively and 6 and 24 months postoperatively in 23 patients by use of a total body counter (40K) and an isotope dilution technique. The mean fat mass, cell mass, and intracellular water (ICW) decreased during the first 6 months (p less than 0.001) and remained unchanged at the 24-month test. However, the mean liters of extracellular water (ECW) did not change. Consequently, the ECW/ICW ratio, high in states of malnutrition, rose above postoperative levels. A strong correlation was found between decreases in cell mass and increases in the ECW/ICW ratio.

Adult↗
PubMed1989

Effect on the postprandial glycaemic level of the addition of water to a meal ingested by healthy subjects and type 2 (non-insulin-dependent) diabetic patients.

The effects on postprandial glycaemic reactions of adding a glass of water to a meal were studied in 7 healthy male subjects and 20 Type 2 (non-insulin-dependent) diabetic patients for a period of up to 3 h. The subjects were served a meal of potatoes and meat, with or without 300 ml of water, in random order on two mornings after a 12-h fast. The diabetic patients were considered as well-controlled or not well-controlled according to HbA1c and blood glucose fasting values. Water addition increased the peak blood glucose (p less than 0.02) and serum insulin (p less than 0.02) levels in healthy subjects, and the blood glucose concentration in well-controlled diabetic patients (p less than 0.02). The addition of water also increased the overall blood glucose response, calculated as the positive incremental area, in healthy subjects by 68 +/- 25% (p less than 0.02) and in well-controlled diabetic patients by 40 +/- 14% (p less than 0.01). In poorly-controlled diabetic patients, however, the addition of water did not display significant effects, probably due to the varying fasting glycaemia in these patients. Thus, altering the physical property of a meal by dilution with water can affect the physiological responses; the results are considered to be relevant for the on-going discussion concerning the use of physiological responses to foods as a basis for diet instructions to diabetic patients.

Blood Glucose↗
PubMed1989

Computed tomography of the brain in the diagnosis of and prognosis in normal pressure hydrocephalus.

Thirty-eight patients with normal pressure hydrocephalus were examined by CT before and after a ventriculo-peritoneal shunt operation. Evans ratio, periventricular hypodensity and width of hemispheric sulci, sylvian fissures, cella media, temporal horns and third and fourth ventricle were examined. Twenty-eight patients improved after the operation while 10 were unchanged (non responders). Those patients who improved had more often enlarged third ventricle, enlarged temporal horns and normal sylvian fissures than those who did not improve. No single CT parameter or combination of CT parameters alone could identify responders and non-responders. The ventriculo-peritoneal shunt operation reduced ventricular size (Evans ratio, cella media width), abolished periventricular hypodensity and reduced width of the temporal horns and third ventricle in both responders and non-responders. Reduction of the width of the third ventricle correlated to clinical improvement.

Aged↗
PubMed1989

Gastric emptying and glycemic response after ingestion of mashed bean or potato flakes in composite meals.

Two meals of mashed-bean or potato flakes and meat were served in random order to six healthy male subjects to determine effects on gastric emptying and glycemic reactions. The meals had comparable physical appearance and contained similar amounts of digestible carbohydrate, fat, and protein. No difference in gastric emptying, recorded by gamma camera after mixing 51Cr with the meals, was found between the meals. The bean-flakes meal gave significantly lower blood glucose (p less than 0.01) and serum insulin (p less than 0.05) concentrations than did the potato-flakes meal. The overall blood glucose response, calculated as incremental area under the curves for 2 h, also differed between the meals (p less than 0.05) whereas the overall insulin response did not differ significantly. The low glycemic response after bean flakes could not be explained by the gastric emptying rate, which provides additional evidence for the slow digestion of bean starch in the small intestine.

Adult↗
PubMed1989

Dietary guar gum effects on postprandial blood glucose, insulin and hydroxyproline in humans.

Meals (425 kcal) containing various doses of guar gum (0, 2.5, 7.5 or 12.5 g) were ingested by nine healthy male subjects after a 12-h fast. The rise in blood glucose was higher after the control meal without guar gum than after the guar gum-containing meals, which all gave a similar rise in glucose. In contrast, increased doses of guar gum led to a greater reduction in the postprandial rise in insulin. The postprandial increase in serum hydroxyproline, an amino acid added to all meals, was decreased in a similar manner by all of the guar gum doses. Gastric emptying was measured after the control meal without guar gum and the meal containing 12.5 g of guar gum by monitoring 51Cr, which was added to the meals. Guar gum was found to reduce the variation between individuals, as well as the initial rate of gastric emptying, which correlated with changes in both serum hydroxyproline (rs = 0.93, P less than 0.01) and blood glucose (rs = 0.83, P less than 0.01). The effectiveness of guar gum in reducing postprandial response was lost after heating and homogenization for canning. A threshold in the reduction in rise of glucose or hydroxyproline was reached with the lowest dose (2.5 g) of viscous guar gum; larger doses had no additional effects. The reduced absorption seems to be an effect of a slower gastric emptying rate.

Adult↗
PubMed1988

Bile acid and cholesterol excretion in human beings given soya-bean- and meat-protein-based diets: a study in ileostomy subjects.

1. The effect of partial replacement of meat protein with three different soya-bean-protein products on bile acid and cholesterol excretion was studied in seven ileostomy subjects. Four different tests diets containing 60 g meat, rice and bread protein, or a replacement of 250 g protein/kg total dietary protein by soya-bean protein from soya-bean flour, soya-bean concentrate or soya-bean isolate, were randomly assigned to the subjects in 2-d periods. 2. Ileostomy contents were collected at 2-h intervals during the day and in one portion during the night, and immediately deep-frozen to avoid bacteriological degradation. Bile acids and cholesterol were quantified by gas-liquid chromatography. 3. No difference in daily excretion of bile acids and cholesterol was noted between test diets. Ileostomy sterol concentrations were lower when soya-bean products were fed. 4. Incorporation of moderate amounts of soya-bean products in solid diets does not seem to affect short-term sterol balance in man.

Adult↗
PubMed1988

Effect of dietary phytase on the digestion of phytate in the stomach and small intestine of humans.

The purpose of this study was to investigate whether dietary phytase is involved in the hydrolysis of phytate in the stomach and small intestine of humans. The digestibility of phytase-deactivated wheat bran was studied on eight occasions and untreated wheat bran on two occasions in healthy ileostomates. Five subjects were studied for two 4-d periods and one subject on two occasions for two 4-d periods while fed a constant low fiber diet. The low fiber diet was supplemented with 16 g/d wheat bran in the second period. Three other subjects fed a low fiber diet were studied for 10 consecutive days, bran being added to the diet on d 5, 6 and 7. Inositol hexaphosphate and its degradation products were analyzed with a recently developed HPLC method. On average, 95% of the ingested phytate from phytase-deactivated wheat bran and 40% of the ingested phytate from untreated wheat bran were recovered in ileostomy contents. These results differ from those of a previous analysis using an iron precipitation method. Mucosal phytase and alakaline phosphatase, if present in the human small intestine, do not seem to play a significant role in phytate digestion in humans, whereas the dietary phytase may be an important factor for phytate hydrolysis. Iron precipitation methods are not adequate for determinations of phytate digestion.

6-Phytase↗
PubMed1988

Total body water and total body potassium in ileostomy patients before and after conversion to the continent ileostomy.

Total body water (TBW) and total body potassium (TBK) were studied in 40 ileostomists before (with conventional ileostomy) and one year after conversion to a continent ileostomy. Each patient acted as his own control. Total body water was determined by using an isotope dilution technique and TBK by counting the gamma radiation from the naturally present nuclide 40K in a whole body counter. Measured values of TBW and TBK were compared intraindividually (conventional versus continent ileostomy) and also with 'normal values' obtained from the same laboratory and based on a multiple regression analysis of data from 476 healthy controls. There was no evidence of water or potassium depletion in ileostomy patients, neither before nor after construction of the continent ileostomy.

Adult↗
PubMed1988

Influence of exchanging polyunsaturated fat for carbohydrate on bile acid and cholesterol excretion in ileostomy patients.

The effects of exchanging sunflower oil for isocaloric amounts of starch hydrolysate on bile acid and cholesterol excretion was studied in six ileostomy subjects. Enteral diets were used to minimize the influence of dietary fibre. Continuous drips of two low-cholesterol liquid enteral formulas, one medium-fat polymeric and one low-fat peptide diet, both containing sunflower oil, were administered for 4-d periods through nasogastric tubes in random order. Ileostomy sterol excretion was quantified by GLC. On the low-fat diet (more carbohydrate) compared to the medium-fat diet (more sunflower oil), net cholesterol excretion was lower in all subjects (P less than 0.05). Bile acid excretion tended to be higher (n.s.), so that mean net sterol excretion remained unchanged. The observations suggest that the consequences on total small bowel sterol excretion of replacing polyunsaturated fatty acids with carbohydrate are small or absent.

Adult↗