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Biomedical subjects

G Wolff

Publications and source records attributed to G Wolff.

At least 235 records · Page 13Linked to original sources
PubMed1976

[Problems with hyperalimentation in intensive care units (author's transl)].

The application of parenteral nutrition in patients in intensive care units can be limited by shock, septicemia and metabolic disorders. Stress- or trauma-induced glucose intolerance sometimes makes it difficult to maintain the caloric requirements with glucose. Sugar substitutes seem to be of advantage in these cases. Meticulous care is essential to avoid severe complications arising from the use of the central venous feeding catheters.

Critical Care↗
PubMed1976

[Freshly frozen preserved plasma for the treatment of intravascular coagulation in polytraumatized patients].

Coagulation disorders in hemorrhagic shock need not represent an isolated intravascular coagulation. They may also occur as a complex of local disseminated intravascular consumption, extravascular consumption, dilution, and reduced synthesis of coagulation factors. In the severely bleeding patient with hemorrhagic diathesis heparin is contraindicated because it does not normalize coagulability. Therefore, it fails to stop hemorrhage and shock remains untreatable. Fresh frozen plasma, however, has proved to be suitable as simultaneous substitution therapy of coagulopathy and of hypovolemic shock. 11 patients suffering from traumatic-hemorrhagic shock associated with intravascular coagulation and hemorrhagic diathesis were successfully treated with fresh frozen plasma, after conventional shock therapy had failed over a period of hours.

Blood Preservation↗
PubMed1976

Indwelling catheter and risk of urinary infection: a clinical investigation with a new closed-drainage system.

A new device for the drainage of an indwelling urethral catheter is described. The disposable one-piece-set includes the connector to the catheter, the tubing, and a cylinder to collect a urine aliquot up to 150 ml. Disconnection is impossible. The urine passes through a siphon which prevents air bubbles rising along the tubing. Aurine sample for bacteriological culture can be withdrawn from the closed system by sterile puncture of this siphon. The calibration of the cylinder enables accurate measuring of urine flow rate even in oliguric patients. The apparatus was tested in 250 patients (1386 patient-days) by daily bacteriological cultures. Compared to the literature it is at the moment the most effective system preventing urinary infection during catheter drainage.

Catheters, Indwelling↗
PubMed1976

[Therapy of refractory ventricular tachycardia in congenital diverticulum of the left ventricle. Clinical aspects and surgical therapy of a rare malformation].

True congenital diverticulum of the left ventricle is an extremely rare lesion, usually associated with defects of the pericardium and the diaphragm. It is defined as a finger-like extension of the ventricular chamber with its wall consisting of all three layers of a normal heart-wall and with the ability to contract properly. Additional cardiac malformations may lead or contribute to early death; if not, the patients die from rupture of the diverticulum. To our knowledge the isolated form without pericardial defect has been reported only once before. The findings are described in an adult who presented with ventricular tachycardia at the age of 43 years. Complete normalization was achieved by resection of the diverticulum with the aid of cardiopulmonary bypass. The literature is reviewed for comparable cases. Etiological considerations are presented and the clinical features are discussed.

Adult↗
PubMed1976

Management of bleeding disorders in traumatic-haemorrhagic shock states with deep frozen fresh plasma.

Coagulation disorders in traumatic-haemorrhagic shock need not represent a simple coagulation problem. They may also occur as a complex of local and disseminated intravascular consumption, dilution, extravascular loss and depressed synthesis of coagulation factors. In the severely bleeding patient with a haemorrhagic diathesis heparin is contrainedicated because it does not normalize coagulability immediately. Therefore, it fails to stop haemorrhage and the shock becomes untreatable. Fresh frozen plasma, however, has proved to be suitable as a simultaneous substitution therapy for the coagulation disorder and the hypovolaemic shock. 25 patients suffering from severe traumatic-hemorrhagic shock associated with coagulation disorders and haemorrhagic diathesis were successfully treated with fresh frozen plasma, after conventional shock therapy had failed over a period of 2 hours. The success was documented clinically and by numerous laboratory tests. Thrombocytopenia has only a secondary responsibility for the haemorrhagic state.

Blood Preservation↗
PubMed1976

[Microparticles in heart operations with extracorporal circulation (author's transl)].

Disturbances of the microcirculation during extracorporal circulation are not yet clearly understood. Many authors think that microembolism is reposible. In two groups of patients with different perfusion techniques we were looking for microparticles with a new constant pressure filtration method using the Agglometer r apparatus. During the by-pass no particles were found. Yet, we found particles in the priming when blood was used, in the suction blood and in special blood samples after contact with the pericardium. In these cases it was always possible to eliminate the particles with special filters. The particles in the suction blood seemed to originate from the extracardial blood portion coming from the pericardium. This portion seemed to be responsible for postoperative complications such as hemolysis and petechia. These complications could not be seen when extracardiac suction blood was eliminated or filtrated.

Adult↗
PubMed1976

Effect of hemorrhagic shock on intrapulmonary right-to-left shunt (QS/QT) and dead space (VD/VT).

The effect of hemorrhagic shock on intrapulmonary right-to-left shunt and dead space ratio was investigated in spontaneously breathing dogs under barbiturate anesthesia. Intrapulmonary right-to-left shunt was reduced sufficiently to offset the marked increase in arteriovenous oxygen difference and PaO2 did not fall. Dead space ratio was increased markedly; therefore, in shock, sufficient CO2-elimination depends on severe hyperventilation. According to this empirical findings, a decrease in PaO2 in shock must not be interpreted as a consequence of the shock itself, but it implies an additional pulmonary pathology.

Animals↗
PubMed1976

[On epidemiology of gastric cancer (author's transl)].

257 stomach cancer patients and 766 controls were interviewed using a standardized questionnaire for 35 variables. The two groups were compared by multivariate variance analysis. This analysis results in a combination of 20 variables significantly connected with gastric cancer. The rankorder of the most prominent variables is as follows: no food intolerance, higher alcohol consumption, living place near Berlin, occupation labourer, early loss of teeth, car driving, no gallstones, smoking and age. It can be assumed that these variables are of aetiological importance. In the aetiology of gastric cancer, exogenous cancerogens seem to play a more important role than endogenous factors. In two further multivariate variance analysis, control group is divided into persons with and persons without chronic gastritis verified by blind gastric biopsy and compared with gastric cancer patients, too. A fourth analysis is limited to female only. The results of the three last mentioned analysis are similar to those of the first one and also similar to results from other countries based on univariate analysis. The computed combination of variables was used for diagnosis of gastric cancer by discriminance analysis in the persons forming the material for this study. This diagnosis was correct in 71% of gastric cancer patients and in 72% of control persons.

Aged↗