Search PubMed⌕ Search

Biomedical subjects

G Weiler

Publications and source records attributed to G Weiler.

At least 109 records · Page 6Linked to original sources
PubMed1975

[Morphological findings in Zieve's syndrome (author's transl)].

The macroscopic and microscopic findings of a case of Zieve's syndrome are described (fatty liver, icterus, hyperlipemia and hemolytic anemia in chronic alcoholism). The outstanding macroscopic finding is milky turbidity of the blood in arterial and venous vascular channels as well as hepatomegaly and anaemia of internal organs. A prominent feature of the histological picture is the high-grade lipaemia of the large and small vessels (arteries and veins), capillary occlusions resembling fat embolism in all organs and severe diffuse fatty metamorphosis of the liver. Circulatory disorders and the cause of death are discussed.

Adult↗
PubMed1975

[Contribution to the morphometry of coronary arteriosclerosis (author's transl)].

In 94 cases with and without coronary arteriosclerosis or various cardiac diseases the coronary arteries were pressure fixed, filled with a mixture of barium sulfate and gelatine for coronary angiography and dissected in 1 cm long segments for morphometry. On consecutive cross sections of the three main branches of the coronary arteries the absolute area of lumen, intima and media as well as of the thickness of the intima and media were measured. From the numerous data of the coronary arteries different indices on coronary arteriosclerosis and by correlation to the heart weight also on coronary insufficiency had been calculated. Using these quantitative data age dependent intimal changes could be distinguished convincingly from cases with uncomplicated coronary arteriosclerosis and cases with hypertension or infarcts. Thus in forensic pathology comparative evaluations can be made in regard to the extent, severity and significance of acute and chronic coronary insufficiency.

Acute Disease↗
PubMed1975

[The number of nuclei and the thickness of the media and intima of the coronary arteries of normal hearts in the second and third decades of life and in hearts with coronary sclerosis and hypertension].

The number of nuclei in the cells of smooth muscle of the media, and the thickness of the media and intima of coronary arteries were investigated by histometric measurements with regard to their behaviour in different stages of life In normal hearts and in hearts altered by disease. Seven normal hearts in the second decade of life, 7 normal hearts in the third decade, 5 hearts with coronary sclerosis (average age 33 years) and 5 hearts with hypertension (average age 47 years) had been examined. After fixing the coronary arteries under a pressure of 110-130 nm Hg and postmortem coronary angiography, the anterior descending and circumflex rami of the left coronary artery and the right coronary artery were cut into blocks of tissue 1 cm long from which frozen sections were made after embedding in gelatine and HE staining. The number of cell nuclei and the thickness of the media and intima were determined micrometrically along 8 radii of each cross-section. From the quantitative findings for the 3 arterial branches in the individual case, a mean value was obtained for each parameter, and from these, a mean value for each group. In normal hearts and in coronary scelrosis, the number of cell nuclei decreases steadily towards the periphery of the cross-sections. In hypertension, in which the highest numbers of cell nuclei are found, hyperplasia of the cell nuclei right into the periphery is marked. The mean number of nuclei/100 mu thickness of media remains the same in all cross-sections of normal and pathological hearts alike. The average number of nuclei in the first 4 cross-sections of the three arterial branches increases from the second to the third decade, through the casses with coronary sclerosis to the cases with hypertension in the proportions 5.6 : 6.7 : 10.7 : 11.7. The difference between the third decade and coronary sclerosis decreases from the first 4 cross-sections to half, while between the coronary sclerosis and hypertension it increases. Hypertrophy and atrophy of the muscle fibres are not taken into account in these measurements. The thickness of the media in the groups behaves like the number of nuclei: in hypertension with the highest values, there is no significant decrease as far as the 8th cross-section, while in the coronary sclerosis and third decade groups the values come closer together after the 6th cross-section. The difference in the middle and peripheral vascular sections are more distinct than in the proximal sections for coronary sclerosis and hypertension. The thickness of the media increases from the second decade to the hypertensive group in the first 4 cross-sections from 70 mu through 106 mu and 131 mu up to 167 mu. The thickness of the intima increases distinctly more rapidly in comparison to the media from 52 mu through 95 mu, 203 mu to 279 mu in hypertension. The media of the coronary arteries in coronary sclerosis and to a greater extent in hypertension, undergo an increase in functional material through hypertrophy and hyperplasia.

Adult↗
PubMedDate not supplied

[Quantitative morphology of the coronary arteries in the second and third decades of life (author's transl)].

1. In 8 cases in the second decade and 10 cases in the third decade without coronary sclerosis and 5 cases with early sclerosis quantitative measurements were made on graded sections of the coronary arteries which were fixed in toto by compression. The surfaces of the lumen, intima and media were determined planimetrically and the thickness of the intima and media and the radius of the lumen of the three main branches of the coronary arteries were determined micrometrically. A post-mortem coronary angiogram was made of each heart and the connective tissue content of the right and left heart was determined planimetrically. 2. Higher values are found in the absolute measurements of surface and thickness of each cross-section in the third decade than in the second. In both age groups the anterior descending ramus is predominant in all criteria. About the end of the second decade the intima attains the thickness of the media and shows the greatest variability of all parameters, especially in the second decade. In both decades the media plays an equally important role in growth as the intima. In the anterior descending ramus the intima has a higher percentage growth rate than in the right coronary artery and in the left ramus circumflexus. In the third decade it has reached a mean thickness of 122 mu in the initial part of the anterior descending ramus and a mean surface area of 1.18 mm2. In the same area the mean thickness of the media also in the third decade, would be 124 mu, and the mean surface area of the media 1.64 mm2. 3. The indices of coronary sclerosis and coronary insufficiency were determined by the method of Freudenberg, Knieriem, Möller and Janzen (1974). Using the mean values for the second and third decades and calculating the regression in the fourth to seventh decades, we found as upper normal limits a coronary sclerosis index of I = 0.3 for hearts without coronary sclerosis, for the coronary sclerosis index II = 0.6, for the coronary insufficiency index I = 0.3, for the coronary insufficiency index II = 0.6 and for the coronary insufficiency index III = 1.0.

Adolescent↗
PubMedDate not supplied

[Morphometrical examinations in cases of stenosing coronary sclerosis and their importance for evaluation of competing causes of death (author's transl)].

Coronary sclerosis is generally supposed to be the most important factor for coronary thrombosis, myocardial infarction and coronary heart death. Stenosing coronary sclerosis may be postmortally documented by angiography and morphometry. It is possible to obtain sufficient morphological data to suggest acute cardiac insufficiency, if the maximum grade of stenoses as a functional parameter and the heart weight are regarded in addition to the quantitative results of the three main branches of the coronary arteries (lumen and intima areas). Generally the cardiac results of autopsy are used individually and subjectively for the explanation of the cause of death. The conclusiveness of these results of autopsy depends on the circumstances of death and the existence of further pathological findings. Competing causes of death may exist in the form of illnesses, injuries, alcoholic and drug effects, physical strain and emotional stress or medical provisions. The quantitative valuation of the cardiac findings with a critical limit for an acute coronary death permits a more exact interpretation of such competing causes of death. This method of examination may also reveal an unpresumed competing cause of death, for example an intoxication. This was demonstrated by four autopsy cases.

Adult↗
PubMedDate not supplied

Morphometrical investigations into alterations of the wall thickness of small pulmonary arteries after birth and in cases of sudden infant death syndrome (SIDS).

In 1973 Naeye was the first to demonstrate that, in cases of SIDS, the small pulmonary arteries have more smooth muscle than in controls and suggested that this is a consequence of chronic alveolar hypoxia. Seventy-five cases have been investigated morphometrically in order to obtain quantitative data on the alterations of wall thickness of the small pulmonary arteries after birth and in cases of SIDS. The investigations comprise seven cases of stillbirth, 19 cases of newborn, 33 cases of SIDS and 16 controls. In each case the thickness of the media, the external diameter of the artery and the media area have been measured planimetrically for 90 arteries ranging between 50 microns and 500 microns. A media index was calculated as the ratio of the thickness of the media to the diameter of the artery. Using this index a thickening of the media of the small pulmonary arteries, corresponding to the situation in fetal and neonatal life, has been confirmed for cases of SIDS. The normal postnatal changes in the small pulmonary arteries, media thinning and enlargement of the lumen, could not be observed in SIDS cases in the first year of life.

Adult↗
PubMedDate not supplied

Mitochondrial calcium during liver carcinogenesis due to thioacetamide and 4-dimethylaminoazobenzene.

In a series of experiments the prolonged feeding of rats with thioacetamide and 4-dimethylaminoazobenzene provoked an increase in mitochondrial calcium. It seems likely that this continuous mitochondrial overloading with Ca2+ is related to metabolic and functional changes of the liver cell leading to a neoplastic transformation. The drastic changes in cell membrane permeability of cholangiocarcinoma tumor cells, reflected by an increased concentration of extracellular cations (calcium and sodium), while the intracellular cations tended to decrease, indicate that the mitochondrial function of specification of cell membrane characteristics is possibly impaired by that calcification.

Acetamides↗
PubMedDate not supplied

[Self-impalement after thoracic stab wound. An unusual method of suicide in psychotic symptomatology].

A 35 year-old male was found dead within a vast collection of garbage in his parent's house with 13 stab wounds of the thorax. 6 years before death he had suffered from a severe cerebral trauma with intracranial hemorrhage, after which an organic psychosis had ensued. At autopsy besides the stab wounds measuring 1-3.5 cm in length and partly exhibiting a so-called "fish-tail" formation a piece of wood was detected, having penetrated the fourth intercostal space along the sternal border and lacerated the pericardium, right pulmonary hilum and the pleura parietalis at the paravertebral line between the eight and ninth rib. There the leading part of the tool had apparently broken and bent to the left in a nearly 90 degrees angle, thus penetrating the left pleural cavity with a slight laceration of the lower lobe of the lung. From the forensic pathologist's point of view this case of multiple stabbing and additional impalement was at least remarkable and at first sight might have raised a suspicion of homicide due to the extent of the rib penetrations and especially the intrusion of the wooden device, which had been pushed by substantial force into an already existing wound. The police presupposed a suicide based on the personal history and situation at the site, where no traces suggesting an activity of somebody else could be ascertained. Reconstruction of the case and resulting differential diagnostic considerations are to be discussed.

Adult↗
PubMedDate not supplied

[Criminal process record Winckelmann (Triest, 1768). Comments on the criminal process dealing with the murder of Johann Joachim Winckelmann from the forensic historical and legal medicine viewpoint].

Johann Joachim Winckelmann, German historian of ancient art and archaeologist, was born on 9 December 1717 in Stendal, a town in Saxony-Anhalt. At the age of 50 he was murdered on 8 June 1768 in a Trieste hotel. The voluminous original record of the criminal proceedings against his murderer, Francesco Arcangeli, was presumed lost for about 150 years. A new edition in the wording of the original text appeared in 1964. This long sought historical document gives cause for forensic-historical reflections under consideration of the autopsy protocol about Winckelmann, which is likewise a historical document. A considerable change of paradigm in comparison to current autopsy protocols is observed with regard to the evaluation of injuries and the circumstances of death.

Archaeology↗