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Biomedical subjects

G Weiler

Publications and source records attributed to G Weiler.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Morphologic particulars in the peripheral pulmonary artery of the lungs in neonates (author's transl)].

Morphological particulars in small branches of the pulmonary artery in newborn children are described: small diameter; hypercellular intima; thick media; wide adventitia, consisting of connective tissue only; epitheloid cells between intima and media as well as media and adventitia. "Sperrarterien" are also seen. These structural changes in the small branches of pulmonary artery, the reduction of the hypertrophic wall of the right ventricle, and the increase of the magnitude of respiration--processes during the first 4 months of life--are considered important factors in explaining the frequency of sudden infant death during the first 4 months of life.

Endothelium↗
PubMed1980

[The diagnostic significance of coagulated heart blood in cases of death by acute asphyxia (author's transl)].

In cases of death by asphyxia, such as strangulation, hanging, drowning, lack of oxygen, compression of the chest, and carbon monoxide poisoning, the frequency of the liquid and coagulated state of blood in the heart was examined. Coagulated blood in the right heart can be found in cases of strangulation, hanging, and drowning, if simultaneously an elevated blood alcohol was present. The diagnostic significance of this result is discussed.

Alcoholic Intoxication↗
PubMed1980

[Contribution of intracranial "traumatic aneurysm" (author's transl)].

Three clinically and histologically verified cases of "traumatic aneurysm" concerning the a. basilaris, a. communicans posterior, and a. lenticulostriata have been used to demonstrate that these acute and subacute lesions do not belong to the true aneurysms, as defined pathologically and anatomically. They can be considered as acute traumatic lesions of arteries with periarterial hematoma (aneursyma spurium) and should be designated as pseudoaneurysms. Such pseudoaneurysms must not only be differentiated from true aneurysms by radiological and clinical findings but also by histological investigation. An intracranial artery rupture with formation of an pseudoaneurysm due to a blunt injury can also exist without a fracture of the base of the skull. Since traumatic lesions of the striatum arteries are caused especially in children and young adults, the localization of an acute hemorrhage in the basal ganglia does not exclude a traumatic etiology. Early closure of the injury in the artery wall and surroundings by fibrin and thrombotic material with following repairing processes are important for latency between injury and rupture of the pseudoaneurysm.

Brain Injuries↗
PubMed1979

[Coma dépassé: toxicological-diagnostic and forensic aspects of a fenetyllin (captagon) intoxication (author's transl)].

In a case of intoxication by Fenetyllin (captagon) with succeeding coma dépassé it can be shown, that toxicological-diagnostic conclusions can be drawn from the disproportional concentrations between brain and body organs. It may be possible to reveal an unknown intoxication case after autopsy or to contribute to recognition of causality of narcotic incidences after a possible overdose.

Autopsy↗
PubMed1978

[Hemobilia--a contribution to vital reaction (author's transl)].

In 60 autopsies, with and without ante- or postmortem liver injuries bile was analyzed for its blood content, by UV-spectrophotometry. A microhemobilia was found in 20 cases and a visible macro-hemobilia in one case. The aetiology and pathogenesis of the hemobilia are discussed. If artefacts are taken into account, the two forms of hemobilia can be regarded as a vital reaction.

Abdominal Injuries↗
PubMed1978

[Distribution of blood in lungs in the sudden infant death (author's transl)].

In 67 cases of Sudden Infant Death Syndrome (SIDS) the distribution of blood in the lungs was examined by staining paraffinsections of 50 mu with benzidine. A focal, acute emphysema and, frequently, a diffuse, alveolar and also interstitial emphysema exists in all cases. In all parts of the lungs atelectases and dystelectases, some of them covering larger areas, are found. Both atelectases and dystelectases show a high degree of hyperaemia coupled with expanded alveolar capillaries, while emphysematous areas show reduced blood volume. The possible functional significance of the disorder in blood distribution in the lungs for increased hypoxemia and the death mechanism are discussed.

Female↗
PubMed1978

[On heavy-metal poisoning, especially by thallium (author's transl)].

Only thallium poisoning is still of clinical significance among heavy-metal intoxications. Among 1800 cases of poisoning there were 15 caused by thallium, 3 by lead and 1 by iron (none by arsenic or mercury). Among thallium poisonings, 13 were due to suicide, one ending fatally, and two of homicide. Thallium can be demonstrated in urine even after haemodialysis and forced diuresis. As more and more rat poisons contain coumarine derivatives instead of thallium, the number of cases of thallium poisoning is likely to decrease.

Adolescent↗
PubMed1977

[Distribution of blood in the kidney by death from exsanguination (author's transl)].

The distribution of blood in the human kidney in acute and protracted exsanguination has been examined by staining sections (30-50micro) with benzidine. After bleeding to death within a few minutes arteries, aterioles, glomeruli, and the capillary network in the renal cortex are empty. In protracted bleeding to death glomeruli are filled with blood, the vessels of renal cortex are empty except for some little arteries and some vasa afferentia. It may be possible to utilige the intrarenal blood distribution to reach an opinion as to the duration of the fatal hemorrhage and even to distinguish single or multiple episodes of hemorrhaging during the course of fatal exsanguination.

Acute Disease↗
PubMed1977

Hepatocarcinogenesis by thioacetamide: correlations of histological and biochemical changes, and possible role of cell injury.

Hepatocarcinogenesis in rats produced by prolonged feeding of thioacetamide appears as a progressive phenomenon in which morphological changes are associated with important biochemical modifications. It seems most likely that changes in the permeability of cell membrane induced by the carcinogen are responsible for increased intracellular accumulation of Ca2+, and for the ensuring of cell injury produced by Ca2+ overloading of the mitochondria. This calcification of the mitochondria may play a role in the neoplastic transformation of the cell, especially as far as it concerns metabolic behavior and the genetic specification of the permeability characteristics of the transformed cell membrane. The increased synthesis of acid glycosaminoglycans suggests their involvement in calcium-mediated control of tumor development and growth.

Acetamides↗
PubMed1976

Liver tumors induced by 4-dimethylaminoazobenzene: experimental basis for a chemical carcinogenesis concept.

In animals fed 4-dimethylaminoazobenzene there are modifications in the distribution of extra- and intracellular cations in liver. The correlation between the cell ionic permeability changes and the induction of cholangiocarcinoma or hepatoma is analyzed at the light of the histological and biochemical findings. A new concept of chemical carcinogenesis is stated in which the increase of passive Ca2+-influx produces mitochondria damage associated with permanent modifications of the structural and functional characteristics of the cell membranes as well as of the genetic mechanisms controlling cell division.

Adenoma, Bile Duct↗