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Biomedical subjects

G Turpin

Publications and source records attributed to G Turpin.

At least 145 records · Page 8Linked to original sources
PubMed1986

[Physiopathology of primary hyperlipidemias].

The authors review the present status of our knowledge of the physiopathology of primary hyperlipidaemia. The mechanisms of familial hypercholesterolaemia (reduction in the number of LDL receptors on the surface of hepatic and extrahepatic cells) and of type III hyperlipidaemia (an apo E abnormality associated with another metabolic disorder) are relatively well known. However, the physiopathology of the other hyperlipidaemias remains obscure: polygenic hypercholesterolaemia probably due to a disorder of hepatic LDL receptors; combined familial hyperlipidaemia probably due to abnormally high hepatic apo B synthesis; hyperlipidaemia related to defective chylomicron catabolism in which the lipase system plays a central role and hypertriglyceridaemia caused by an association of genetic and environmental factors.

Chylomicrons↗
PubMed1986

[Pregnancy and hyperprolactinemia. Review of therapeutic measures apropos of a series of 35 patients].

Forty-eight pregnancies were observed in 35 patients with hyperprolactinaemia divided into 3 groups according to their initial radiological appearances: normal sella turcica (Group I, n = 11), microadenoma (Group II, n = 12) or macroadenoma without suprasellar expansion, visual defect or pituitary deficiency (Group III, n = 12). Twenty-seven patients were treated with Bromocriptine (Br) from the outs six by adenomectomy + Br, one by adenomectomy alone complicated by meningitis and by corticotropic and thyrotropic hormone deficiencies, followed by amenorrhea despite normalisation of the hyperprolactinaemia requiring induction of a first pregnancy with Clomid. As regards the pregnancies induced by Br (43/48), Br was withdrawn at an early stage in Group I and in the majority of cases in Groups II and III. In all, 37 pregnancies came to term; after Br therapy we observed 5 spontaneous abortions and 3 premature deliveries; 2 caesarian sections were performed before term (one case of hypertension and one adenomatous expansion); one early termination was performed for a tumoral complication. One congenital abnormality (oesophageal atresis) was detected. These observations support the results of extensive studies showing no effects of Br on the outcome of pregnancy and no detectable teratogenic effects with this drug. Five pituitary complications occurred during pregnancy after withdrawal of Br; 1 case of headaches with expansion of a macroadenoma cured by adenometry after prophylactic caesarian section before term; 1 case of optic chiasma compression (Group III) which responded to emergency surgery and 2 cases of pituitary apoplexy (Groups II and III) which responded favourably to Br and in which pregnancy continued normally.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenoma↗
PubMed1986

[Primary hypothalamic tumors (excluding craniopharyngioma). Endocrine and post-radiotherapy development study. Apropos of 17 cases].

The authors underline a number of features of primary hypothalamic tumours (except craniopharyngioma) based on a study of 17 cases: The vital prognosis is satisfactory; only one death was observed with an average follow-up period of 80 months (range 1 to 17 years). This raises the question of the necessity for systematic biopsy to confirm the tumour histology (although when performed in conditions of stereotaxis there are no serious risks). The site of the tumour makes surgery difficult and complete ablation impossible. As many hypothalamic tumours, including the pilocytic astrocytoma which is the commonest type, are sensitive to radiotherapy, this would seem to be the treatment of choice. Total regression is observed in the majority of cases. From the endocrine point of view, the mediocre prognosis is aggravated by high energy radiotherapy. However, with the present therapeutic methods, it is relatively easy to compensate complete or dissociated deficits. There is an endocrine syndrome suggestive of hypothalamic tumour which consists of anterior pituitary deficiency, diabetes insipidus and moderate hyperprolactinaemia (20 to 100 ng/ml). Close medical surveillance is essential, both of the local (visual field and frontal CT scanning) and endocrine effects. Hormonal deficits may occur as a late complication up to 5 years after radiotherapy. The problems inherent to hypothalamic tumours: neurogenic hypernatraemia which is luckily uncommon, with an unexplained weight gain occurring during substitute therapy for adrenal insufficiency with physiological doses of hydrocortisone. Finally, the overall prognosis is good with a minimum of complications due to radiotherapy, excepting endocrine deficiency, providing a dose of 60 grays in 6 weeks at 2 grays per session is not exceeded.

Adolescent↗
PubMed1985

Sensitivity to noise in a community sample: II. Measurement of psychophysiological indices.

A sample of 77 women of high and low noise sensitivity in 1977, living in areas of high and low exposure to aircraft noise, were interviewed in the community in 1980. High, intermediate and low noise sensitive women were compared, using measures of blood pressure, heart rate, skin conductance, hearing threshold, uncomfortable loudness level and magnitude estimation of six tones. These physiological measures did not clearly distinguish different noise sensitivity groups, except that highly noise sensitive women had a consistently slower heart rate. Noise sensitivity was not related to auditory threshold. In the high aircraft noise area there were significantly more skin conductance responses than in the low aircraft noise area irrespective of noise sensitivity. This may be the result of chronic exposure to high aircraft noise.

Adolescent↗
PubMed1985

Testicular response to human chorionic gonadotrophin in chronic hyperprolactinaemia.

In order to evaluate the effect of hyperprolactinaemia on gonadal function in men, testicular stimulation by human chorionic gonadotrophin (hCG) (5000 IU/day, 3 consecutive days) was performed on 6 men with chronic hyperprolactinaemia and 6 control subjects. The following parameters were measured before and during the 4 consecutive days following the injections of hCG: the concentration in plasma of testosterone (T), oestradiol-17 beta (E2), dihydrotestosterone (DHT) and the urinary excretion of testosterone glucuronide (TG) and 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (3 alpha-Diol G). The rises in T, E2, DHT and the ratios of T/DHT and TG/3 alpha-Diol G were similar in both groups, but the rises in TG and 3 alpha-Diol G were lower in the hyperprolactinaemic group after hCG. There was no correlation between the response of T and the increment of E2 in either group. It is suggested that in men with chronic hyperprolactinaemia: 1) there is diminished testicular response to hCG; this could be due to chronic gonadotrophin deficiency or to a direct effect of hyperprolactinaemia on the testes, 2) there is no modulation of T synthesis through inhibition of aromatase activity and E2 secretion and 3) the 5 alpha-reduction of T is not deficient.

Adenoma↗
PubMed1985

[Results of bromocriptine treatment of giant or invasive prolactin adenomas. Apropos of 20 cases].

The therapeutic results of twenty patients with giant expansive prolactinomas were studied under bromocriptine as treatment of first intent (Group I, n = 10) or of second intent after surgery with or without radiotherapy (Group II, n = 10). Patients in Group I (PRL: 350-17 000 ng/ml) were given bromocriptine alone (10 to 20 mg/day) for a period of 21 days to 22 months. The visual fields and acuity returned to normal in 8 days to 3 months in 4 out of 7 patients and significantly improved in 2 out of 7 patients. A reduction in tumour size was demonstrated on CT scanning in 7 out of 10 patients mainly in the suprasellar region (6/9) with appearances of a partially empty sella in 4 cases. Normalisation of the PRL (7 out of 10 cases) was accompanied by a correction of one or more other hypophyseal deficits in 3 patients. Bromocriptine was continued in 5 out of 10 cases with a good result after 12 to 22 months follow-up. Five patients were referred secondarily for surgery for spontaneous rhinorrhea in 1 patient or because Bromocriptine was only partially effective in 4 patients; a postoperative visual improvement with reduced serum prolactin levels was observed in these 4 cases. In Group II (PRL: 200-11 600 ng/ml after surgery), bromocriptine therapy (5 to 30 mg/day for 1.5 to 72 months) was associated with normalisation or a significant improvement in visual symptoms in 6 out of 9 cases and a reduction in tumour size in 8 out of 10 cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenoma↗
PubMed1984

[Mucigenous cysts of the pituitary gland. 3 cases].

Three cases of mucous cysts, or Rathke's cyst, of the pituitary gland are reported. The clinical and biological features were comparable to those of a non-secreting adenoma. Although extremely rare, these cysts must be recognized since their particular and, in theory, specific characteristics (wall made up of a ciliated epithelium with mucus cells and cavity filled with a mucoid substance) distinguish them from other intra or suprasellar pathological formations, especially craniopharyngiomas. The 62 cases reported in the literature suggest that they have a favourable prognosis.

Adenoma↗
PubMed1984

Psychophysiological responses of schizophrenic patients to high and low expressed emotion relatives: a follow-up study.

Measurements of skin conductance response frequencies (SCRf) were obtained from 30 acutely ill schizophrenic patients during a standardised videotaped interview, conducted with the patient's key relative present. Significant differences in SCRf's were demonstrated between patients whose relatives had high and low Expressed Emotion (EE) respectively. Patients at high risk of relapse were allocated either to a control or an experimental group, the latter being offered a number of social interventions in order to reduce the relative's EE and/or contact with the patient. Follow-up measurements were obtained on 19 patients nine months after discharge. Although social intervention was highly successful in reducing relapse rates, its effects did not appear to be directly mediated via SCRf, which was found to be independently related to relapse.

Adult↗
PubMed1984

[Value of hormonal markers in the detection and therapeutic surveillance of malignant adrenal cortical carcinoma].

The value of hormonal markers in the diagnosis and early and late surveillance of adrenocortical carcinoma was assessed in a series of 10 cases and from a review of the literature. Although hormonal investigation with measurement of precursors, performed whenever there is the least clinical suspicion of ACC, is of certain diagnostic value, the possibilities of postoperative controls have not yet been fully exploited: the results are difficult to interpret because of possible interference due to the secretion of the controlateral adrenal; plasma renin activity is rarely assessed in the late postoperative period. A general strategy of investigation and surveillance is proposed.

Adrenal Cortex Hormones↗
PubMed1984

[The blood-testis barrier].

The blood-testis barrier in man is mainly due to the tight junctions of Sertoli cells. It creates favorable conditions for the spermatogenesis and sperm survival in the testicular fluid. It prevents the occurrence of autoimmunity after puberty. The alteration of the blood-testis barrier allows the production of antisperm antibodies and may lead to infertility.

Antibody Formation↗
PubMed1983

[A rare cause of amenorrhea: stenosis of the aqueduct of Sylvius. Apropos of 3 cases. Cure by ventriculo-atrial shunt].

Chronic hydrocephalus by aqueductal stenosis may result in endocrine dysfunction. Primary or secondary amenorrhea may be the only symptom. Endocrine function tests are usually normal, except for low estrogen levels, pointing to isolated functional hypothalamic amenorrhea. Roentgenologic investigations ensure diagnosis in all cases: skull films show enlargement and/or flattening of the sella turcica and digitate impressions; computed tomography shows dilatation of lateral and third ventricles. This rare cause of amenorrhea must be kept in mind as it can be easily diagnosed and successfully treated by atrioventricular shunt.

Adolescent↗
PubMed1983

[Inhibin: its origin, nature and role].

Inhibin is a protein secreted by the Sertoli cells in men and by the granulosa cells in women. It inhibits the synthesis and release of the follicle-stimulating hormone in the pituitary gland and reduces the hypothalamic LH - releasing hormone content. It also inhibits the multiplication of spermatogonias in male gonads and the production of progesterone by the ovaries. Inhibin determinations in biological fluids may help to understand the pathophysiology of puberty, ovulation, menopause and various types of infertility.

Female↗