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Biomedical subjects

G Taylor

Publications and source records attributed to G Taylor.

At least 451 records · Page 25Linked to original sources
PubMed1975

Thymoma associated with pure red cell aplasia, immunoglobulin deficiency and an inhibitor of antigen-induced lymphocyte transformation.

A case of thymoma associated with pure red cell aplasia and hypogammaglobulinaemia is described in which the anaemia was of abrupt onset, following removal of the tumour. Tests of immunological function showed abnormalities of both humoral and cellular immunity. The patient was found to have a serum inhibitor of antigen-induced lymphocyte transformation which disappeared after immunosuppressive therapy at the same time that erythroblasts reappeared in the marrow. It is suggested that the triad of thymoma, pure red cell aplasia and immunoglobulin deficiency are manifestations of 'pluripotent' stem cell failure; in this case the inhibitor of lymphocyte transformation may have been related to the factor which also inhibited red cell maturation.

Agammaglobulinemia↗
PubMed1975

The part played by cell-mediated immunity in mycoplasma respiratory infections.

Intranasal inoculation of M. pulmonis in mice and M. pneumoniae in hamsters results in pneumonia characterised by peribronchiolar and perivascular cuffing by lymphocytes. Thymus-dependent lymphocytes were depleted in mice by thymectomy and X-irradiation or treatment with anti-lymphocyte serum (ALS), and in hamsters by treatment with ALS. These procedures caused a reduction in the severity of pneumonic lesions in infected animals compared with infected immunologically normal animals. In addition, the organisms were present in slightly greater numbers in the lungs of the immunosuppressed animals. These results indicate the importance of thymus-dependent lymphocytes in the pathogenesis of mycoplasma-induced pulmonary disease. However, the role that these cells play in resistance to infection is not known and it may be that local secretory antibody is also important. Results of preliminary experiments involving hamster tracheal organ cultures infected with M. pneumoniae indicate that there is a factor present in lung washings from immune hamsters that protects against loss of ciliary activity brought about by M. pneumoniae.

Animals↗
PubMed1975

Surgery for coronary artery disease and congestive heart failure.

A group of 41 patients presenting primarily with symptoms of congestive heart failure was investigated by coronary arteriography and myocardial revascularization. Of these patients 20 underwent resection of left ventricular aneurysm or left ventricular plication as well as revascularization. Revascularization plus resection of left ventricular aneurysm gives gratifying results, but revascularization in the presence of severe generalized hypokinesis is less satisfactory; however, the improvement in clinical condition in a sufficient number of patients is such that this approach to their management is justified. Accordingly, every patient with coronary artery disease and congestive heart failure should be investigated by angiography. Numerous factors influence the results of revascularization for the relief of congestive heart failure; the most useful as a criterion to aid patient selection is left ventriculography. In this group of 41 patients 66% were helped by myocardial revascularization.

Adult↗
PubMed1975

The influence of the nematode Syphacia oblevata on adjuvant arthritis in the rat.

The effect of infestation with the nematode Syphacia oblevata on adjuvant arthritis was studied in the rat. Animals with an established infestation with Syphacia were found to have a reduced incidence of arthritis after injection of Freund's complete adjuvant. Infested animals developing adjuvant arthritis were found to suffer from a less severe form of the disease than animals in which infestation had been eliminated with piperazine before immunization.

Animals↗