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Biomedical subjects

G Taylor

Publications and source records attributed to G Taylor.

At least 433 records · Page 24Linked to original sources
PubMed1976

Evidence for cell-mediated immunity to renal antigens in minimal-change nephrotic syndrome.

A direct lymphocytotoxicity test was used to investigate 12 patients with minimal-change nephrotic syndrome and 12 patients with proliferative glomerulonephritis for cell-mediated immunity against an epithelial cell culture derived from human kidney. Lymphocytes from patients with minimal-change nephritis but not from those with proliferative disease had significantly greater lymphocytotoxicity against the cultures than did lymphocytes from normal controls.

Antigen-Antibody Reactions↗
PubMed1976

Allograft immunity to histocompatibility and organ-specific antigens.

An experimental model has been developed in the dog in which a renal allograft was placed in the neck, leaving one of the dog's own kidney in situ. Five nonimmunosuppressed pairs of dogs have been studied by using the leucocyte migration test (LMT) as an in vitro measure of cell-mediated immunity. Antigen preparations from leucocytes, kidney, liver, and skeletal muscle from both the kidney donor and the recipient were used in the LMT in order to study responses against transplantation and organ-specific antigens. Inhibition of migration with donor-specific leucocyte and kidney antigens was detectable prior to clinical evidence of rejection, which was confirmed histologically. Concurrently, inhibition was also observed with autologous kidney antigen and histological damage was noted in the recipient's own nontransplanted kidney, accompanied by increasing proteinuria. Autologous serum withdrawn daily and added to the test culture medium abolished the inhibition of migration, thus suggesting the development of blocking factor.

Animals↗
PubMed1976

Local nasal desensitization provoking systemic illness with proteinuria.

We report a case of allergic rhinitis with systemic illness and proteinuria, which was repeatedly provoked by nasal exposure to allergen. Local nasal desensitization resulted in remission of both rhinitis and systemic illness. The disease was associated with systemic complement fixation via the classical pathway.

Adolescent↗
PubMed1976

Interaction of Mycoplasma dispar and Mycoplasma agalactiae subsp. bovis with bovine alveolar macrophages and bovine lacteal polymorphonuclear leukocytes.

Mycoplasma dispar and Mycoplasma agalactiae subsp. bovis survived or grew in cultures of bovine lacteal polymorphonuclear leukocytes or bovine alveolar macrophages. In the presence of specific bovine antibody, macrophages and polymorphonuclear leukocytes appeared to kill both species of mycoplasma. Specific rabbit antisera also promoted the killing of these mycoplasmas by bovine macrophages but had no demonstrable activity for bovine polymorphonuclear leukocytes. It is suggested that phagocytosis of these mycoplasmas by bovine cells occurs only in the presence of specific antibody. The experiments also indicate that differences exist between bovine polymorphonuclear leukocytes and macrophages with regard to their receptor sites for immunoglobulins.

Animals↗
PubMed1976

Immune potential in human uraemia. 1. Relationship of glomerular filtration rate to depression of immune potential.

Aspects of immune potential in uraemic subjects, categorized by glomerular filtration rate, were intercompared and compared with results obtained from a group of normal volunteers. Evidence is presented to show that depression of both cellular and humoral immune potential occurs with progressive reduction of glomerular filtration rate. Lymphocyte transformation testing to the non-specific mitogen PHA revealed a significant elevation of blastogenic response in uraemia after 96 hours of incubation.

Adult↗
PubMed1976

Immune potential in human uraemia. 2. Changes after regular haemodialysis therapy.

Parameters of both humoral and cellular immune potential were measured in a group of patients with severe renal failure before and after three months' regular haemodialysis therapy. Evidence is presented of improvement in cellular immune potential and of a tendency of the response of lymphocytes to PHA to return to normal. No improvement in humoral responsiveness was demonstrable, and it is suggested that uraemic patients on regular haemodialysis may have an impaired capacity to establish new immunological memory.

Antibodies, Bacterial↗
PubMed1976

Effects of active and passive immunization on Mycoplasma pulmonis-induced pneumonia in mice.

Parenteral immunization of C3H mice with viable Mycoplasma pulmonis organisms protected them from pneumonia induced by intranasal inoculation of these organisms. Spleen cells obtained from immunized mice were ineffective in preventing syngeneic recipients from developint respiratory disease. In contrast, convalescent-phase serum enhanced the clearance of mycoplasmas from the respiratory tract of mice challenged with a small number of organisms. Further, although 'immune' serum had no detectable effect on the number of mycoplasmas in the respiratory tract of mice challenged with a large number of organisms, such animals did not develop pneumonia. Since the pneumonia appears to be the results of the host's immune response to the mycoplasma, it is suggested that the transferred 'immune' serum may act by suppressing the immune response so that mice develop less severe lung lesions. This suggestion is supported by the observation that the complement-fixing antibody response of passively immunized mice was suppressed.

Animals↗
PubMed1975

Non-organ-specific and tumour-specific antibodies in children with Wilms' tumour.

Sera from groups of children with Wilms' tumour, with non-renal solid tumours, and from control children were studied by immunofluorescence and by absorption techniques. A high proportion of sera from both tumour groups contained non-organ-specific auto-antibodies. Three of the 45 sera in the Wilms' group and one of the 27 sera in the "other" solid tumour group contained antibody reacting with normal kidney cells. Only one of 45 sera in the Wilms' tumour group contained tumour-specific antibody.

Adolescent↗
PubMed1975

Acid pulmonary aspiration syndrome after antacids. A case report.

This is a report of a patient who developed acid pulmonary aspiration syndrome following pulmonary aspiration of gastric contents at a pH of 3.5. The volume of the stomach contents was large and 15 ml of magnesium trisilicate was insufficient to prevent the effects of acid aspiration. After operation, considerable pulmonary shunting was demonstrable for several days. The patient was discharged home well, and a chest x-ray 2 months later showed no abnormality.

Adult↗