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Biomedical subjects

G Stein

Publications and source records attributed to G Stein.

At least 343 records · Page 19Linked to original sources
PubMed1981

[Clinical significance of complement values in rheumatic diseases].

The more than 10-year experiences with complement examinations in rheumatic diseases are described: Manifold determinations of the complement in the course of the disease may be valuable diagnostic means, taking into consideration acknowledged criteria of the diagnosis in forms of rheumatic diseases with increasing immune pathogenesis. Particularly important are repeated determinations in the synovial fluid with references to a rheumatoid arthritis and in the serum in systemic lupus erythematodes as well as for the limitation of the earliest manifestations of a systemic sclerodermia with positive proof of antinuclear factors.

Complement System Proteins↗
PubMed1981

Dialysability of benzodiazepines by haemodialysis and controlled sequential ultrafiltration (CSU) in vitro.

The efficacy of haemodialysis and controlled sequential ultrafiltration (CSU) for the elimination of three hypnotic and 6 benzodiazepine drugs was compared in vitro. In comparison to haemodialysis the efficacy of ultrafiltration by CSU was poor, as the mean per cent of CSU/haemodialysis (mg/hr) for 5 benzodiazepines was only 0.6-4.0% and for three hypnotics, phenobarbital 3.4%, pyrithyldione 8.2% and glutethimide 2.5% of the haemodialysis values. In haemodialysis in vitro phenobarbital, pyrithyldione, glutethimide and chlordiazepoxide were significantly and markedly more dialysable than 5 other benzodiazepines. The mean clearance of six benzodiazepine derivatives was about 2 to 3 times higher at blood flow rates of 200 ml/min. than 100 ml/min. In CSU experiments in vitro it was possible to remove approximately (as the mean percent of the initial dose) only the amount of five benzodiazepines corresponding to the per cent of the protein unbound fraction in the plasma (correlation r = 0.975, P less than 0.01). Only low amounts of three hypnotics, especially glutethimide, were removed by CSU in vitro.

Benzodiazepines↗
PubMed1981

A large group in a district general hospital.

This article describes a large group in a district general hospital serving a defined catchment area. Fifteen consecutive meetings were studied and three types of meeting were observed; manic meetings, depressed meetings and, thirdly more balanced meetings not dominated by any powerful affect. The main topics discussed in the meetings included depression, illness, anxieties about treatment or recurrence, doctors, bereavement, loneliness, religion, and death, the more medical subjects possibly reflecting the medical orientation of the treatment programme. The principal themes in this meeting differ from those described in therapeutic communities, when themes of violence, rejection, sexuality and dependence conflicts figure more prominently. In the setting of the district general hospital, the character of the meeting appeared to be largely determined by the composition of the ward at the time, and patients with affective disorders. by virtue of their powerful moods, often assumed a dominant role.

Affect↗
PubMed1981

Measurements of nonspecific humoral immune parameters in patients with chronic pyelonephritis.

The levels of autoantibody classes IgG, IgM, IgA, IgD against renal antigens together with CH50, C3, C4, lysozyme, and phagocytic activity against Staphylococcus aureus SG 511 and E. coli 014 were determined in serum samples from 3 groups of patients with chronic pyelonephritis. Increased levels of IgG and IgD were found in patients with severely impaired renal function while increased levels of IgM and IgD correlated with disease activity. C3 levels were increased with enhanced activity and C4 and lysozyme levels with reduced renal function and distinct activity. The value of these findings is discussed and the clinical usefulness of the determination of levels of IgM, IgD, C3, C4, and lysozyme is pointed out.

Antibody Formation↗
PubMed1981

[Serum and urine lysozyme in chronic pyelonephritis and chronic glomerulonephritis].

In 130 patients with chronic pyelonephritis and 215 patients with chronic glomerulonephritis the serum lysozyme content was established and in 114 and 186, respectively, the enzyme content of their urine tests. Moreover the lysozyme measurement in the serum of 28 patients undergoing haemodialysis was performed. A collective of 50 healthy persons served as comparative group. The lysozyme estimation was performed by means of the agar-diffusion technique after Ossermann and Lawlor in own modification. The average serum lysozyme levels of the patients with pyelonephritis (mean =7.3 micrograms/ml) as well as of the patients with glomerulonephritis (mean = 5.7 micrograms/ml) were significantly increased in contrast to the control group (mean = 4.5 micrograms/ml). Differences could be recognized between the various forms of glomerulonephritis. 34.2% of the patients with pyelonephritis and 37.1% of the patients with glomerulonephritis showed a lysozymuria. In functional restrictions of the kidneys as well as in active forms of the diseases increased concentrations in serum and urine could be established.

Adult↗
PubMed1981

[Cell proliferation kinetics in the small intestine of rats with injured kidneys (author's transl)].

Cell proliferation studies were performed in the duodenum, jejunum and ileum of 10 rats 5 months after 5/6 nephrectomy. The control group consisted of 8 unoperated rats. The results showed no differences in the labeling index, in the localisation of the proliferation within the crypts of Lieberkühn and in the migration of labeled cells from the crypts to the top of the villi in both groups. These results may be explained by the small degree of renal insufficiency.

Animals↗
PubMed1981

[Local low-dose streptokinase therapy of shunt thrombosis in chronic hemodialysis patients].

In two patients undergoing haemodialysis on account of a thrombosis of the saphena transplant a local thrombolytic treatment with 50,000 units Awelysin was performed 2--3 times a day. In the two cases after 4 or 5 days a recanalisation developed, in one patient, however, a new thrombosis developed. As prerequisite for the success a sufficiently high shunt flow before the thrombosis is regarded. The exact coagulation-physiological control in the transposition phase from heparin to oral anticoagulants is particularly important.

Adult↗
PubMed1981

[Genesis of microcytes in hemodialysis patients with chronic uremia].

The study is concerned with factors that may reduce the life time of erythrocytes of patients under intermittent haemodialysis. The red cell population of these patients consisted of micro-, normo-, macro- and megalocytes. The classification of the cell size was shiftet to greater diameters in comparison with healthy donors. The evaluation of the biological half time of erythrocytes labelled with 51Cr resulted in a decrease of about 16 days. The autoradiographic evaluation of the erythrocyte size-distribution patterns 1 and 24 hours after the injection of labelled red cells into the donors circulation clearly demonstrated a decrease of macro- and megalocytes. Simultaneously, the number of microcytes rose considerably. The measurement of erythrocyte deformability could demonstrate a clearcut relationship of flexibility for a) disturbed erythropoiesis resulting in the production of macro- and megalocytes, and b) fragmentation and premature elimination from the circulation due to unfavourable rheologic properties of erythrocytes of abnormal big and small sizes.

Autoradiography↗
PubMed1980

[Infusion therapy and parenteral nutrition in acute renal failure and chronic renal insufficiency].

In patients with acute renal insufficiency as well as in patients with chronic renal insufficiency a parenteral nutrition may become necessary in the different stages of the course of the disease. Taking into consideration the principles of the exact balance of the fluid metabolism, the electrolyte metabolism and of the acid-base-metabolism, the access of sufficient quantities of calories for the inhibition of the catabolism and the possibility of an anabolism as well as of the adapted amino acid substitution for the maintenance of an equalized nitrogen balance the parenteral nutrition is an effective method for influencing the disturbed renal function and the removal of complications dangerous to life.

Acid-Base Equilibrium↗
PubMed1980

[The unusual case: Wegener's granulomatosis].

In a casuistic report of a case of Wegener's granulomatosis the diagnostic and therapeutic problems of a relatively rare clinical picture are described. Special emphasis is laid on the variety of organic manifestations and on the fact that bioptic investigations have not resulted in typical findings leading to diagnosis. Despite immunosuppressive therapy the lethal exitus cannot be influenced.

Adult↗
PubMed1980

[Are coronary patients endangered through arrhythmias in diving?].

In 25 patients suffering from coronary heart disease with myocardial infarction electrocardiograms were registered continuously during diving and under water swimming. The results are compared to findings in the same patients during bicycle ergometry. Submersion under water produced a highly significant bradycardia and an increase of arrhythmias. During under water swimming heart rate increased less than during 50 Watt ergometry and premature beats were very frequent. It is discussed that the diving bradycardia combined with breath holding provokes the accumulation of arrhythmias. After myocardial infarction patients should not submerge the head under water.

Arrhythmias, Cardiac↗
PubMed1980

[EEG and ENG findings in patients with chronic renal insufficiency and in hemodialysis patients].

In 15 patients with renal insufficiency at the stage of the compensated retention and 13 patients of the chronic haemodialysis programe no relations between clinical findings, maximum motor nerve conduction speed (peroneal nerve, median nerve), visually evaluated EEG and actual metabolic parameters could be statistically secured. During haemodialysis either an increase of the EEG changes increased or the findings remained constant.

Adult↗