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Biomedical subjects

G Schmidt

Publications and source records attributed to G Schmidt.

At least 487 records · Page 27Linked to original sources
PubMed1982

Paroxysmal tachycardia and cardioversion during pregnancy.

Synchronized direct current (DC) cardioversion was used successfully for treatment of a pharmacologically refractory supraventricular tachycardia during pregnancy. No maternal or fetal complications or ill effects occurred. Although few cases have been reported, a review of the literature supports the use of synchronized DC countershock therapy for the treatment of certain arrhythmias during pregnancy. Thorough knowledge of electrocardioversion techniques and of concurrent fetal monitoring is recommended.

Adolescent↗
PubMed1982

Discrimination of several classes of nonhistone proteins in chromatin fractions from liver and thymus nuclei of rats.

Nonhistone proteins (NHPs) of salt-soluble chromatin (Chromatin S) and of the residual nuclei (Chromatin P) from rat liver and thymus were studied by SDS-polyacrylamide gel electrophoresis. The two chromatin fractions of the liver showed significant differences in their NHP patterns with most of the hnRNP and matrix proteins occurring in Chromatin P. In accordance with the low protein content of thymus nuclei, the corresponding thymus fractions exhibited electrophoretic patterns with a markedly lower amount of NHPs than in liver. Chromatin P from thymus, in contrast to the liver fraction, revealed only a very low content of hnRNP-specific proteins of molecular weight 30,000-40,000 (30 K to 40 K) (informosomal proteins) consistent with the significantly lower RNA content of thymus nuclei. In the region of the matrix proteins (60-75 K) Chromatin P showed only two bands of about 64 K and 73 K in thymus, whereas in liver five strong bands at 64 K, 66 K, 69 K, 73 K, and 75 K were found. RNase digestion was employed to discriminate hnRNP-specific protein from "real" chromosomal NHPs. At least about 65% and 25% of the NHPs from Chromatin P and S of liver, respectively, were found to be RNP-specific. The two chromatin fractions were further fractionated by sucrose gradient centrifugation and isopycnic banding in metrizamide. After centrifugation the main peaks, both of Chromatin S and P, contained only minor amounts of NHPs with a predominating protein of 38 K. By the centrifugation procedures described in this paper, a small subfraction of chromatin could be separated which was enriched in newly synthesized RNA, informosomal proteins, matrix- and other high molecular weight proteins. This subfraction might be related to transcriptionally active chromatin.

Animals↗
PubMed1981

Psychosurgery of sexually deviant patients: review and analysis of new empirical findings.

From 1962 to 1979, 74 men and one woman considered sexually abnormal have received surgical hypothalamotomies in the Federal Republic of Germany. This paper reviews the neurophysiological assumptions behind the surgery, the criteria for surgery, and the effects and side effects of surgery as far as has been documented by medical, psychiatric, psychological, sexual, and social data. The neurophysiological bases for hypothalamotomies on humans with deviant sexual behavior appear dubious, the indications make use of questionable scientific and clinical categories and assumptions, few reliable data have been submitted for side effects, and follow-up studies are based on poor methodology. Restrictive regulations against this type of "experimental therapy" are suggested.

Adult↗
PubMed1981

Escherichia coli adhesion to Saccharomyces cerevisiae and mammalian cells: role of piliation and surface hydrophobicity.

A number of Escherichia coli strains isolated from patients with urinary tract infections, bacteremia, or diarrhea were studied with respect to their (i) capacity to agglutinate human AB, bovine, and guinea pig erythrocytes as well as yeast (Saccharomyces cerevisiae) cells; (ii) adhesion to monolayers of cells from human intestine (intestine 407; ATCC CCL6), monkey kidney (Vero; ATCC CCL81), feline embryo (Flow no. 05-552), and porcine kidney (PK1; ATCC CRL1392) and of primary rat kidney cell cultures; and (iii) surface hydrophobicity as measured by hydrophobic interaction chromatography. No correlation could be found between the capacity of the bacteria to adhere to the different cultured mammalian cells and their agglutination patterns. The results indicated not only a complexity of bacterial receptors on the eucaryotic cells, but also a multiplicity of bacterial adhesions as expressed by the selectivity of bacterial binding. Binding of bacteria was found to be attributed to the presence of pili on the bacterial surface. It was observed that the bacteria were differently piliated: some had only common type I or related pili which gave rise to mannose-sensitive (MS) adhesion or agglutination (MS pili), some had only pili which gave rise to mannose-resistant (MR) adhesion or agglutination (MR pili), and some had both MS and MR pili. Bacteria with MS pili were more hydrophobic than those with MR pili or with none at all.

Agglutination↗
PubMed1981

Urinary free cortisol excretion in endogenously depressed and schizophrenic patients.

In 8 endogenously depressed and 9 schizophrenic patients, the excretion of urinary free cortisol was measured. The endogenous depressives exhibited a significantly (p less than 0.01) higher excretion of free cortisol (X = 122 microgram/24 h or X = 68 microgram/24 h) when compared to schizophrenics. This finding, earlier reported by others, suggests a hypothalamic-pituitary-adrenocortical activation in endogenously depressed patients.

Depressive Disorder↗
PubMed1981

[Use of beta-adrenergic blocking agents in acute myocardial infarction (author's transl)].

Beta-adrenergic blocking agents exert a number of pharmacologic effects which may potentially be beneficial and warrant their use in acute myocardial infarction: by decreasing heart rate, myocardial contractility and systolic blood pressure, reducing catecholamine-induced lipolysis and antagonizing the oxygen-wasting effects of catecholamines on the myocardium, myocardial oxygen balance may be improved thus reducing ischemia. Theoretically this may lead to a limitation of infarct size by protecting underperfused myocardium from ultimate necrosis. Definite proof for such a positive effect in man, however, is not yet available. In animals a number of experimental findings either indirectly of directly demonstrate the potential protective effect of beta-blockers on ischemic myocardium. Early treatment is able to significantly prolong myocardial survival time and limit the area of myocardial damage to about 50% as compared with untreated controls. Experience with treatment of myocardial infarction in man has shown that beta-blocking agents are well tolerated in patients presenting in hemodynamically stable condition (Killip groups I and II). By reducing heart rate as well as pressure and volume work of the heart and reducing serum-free-fatty-acid concentration, myocardial oxygen demand is greatly diminished. A reduction of myocardial O2-consumption and improvement in oxygen balance has been demonstrated in man. Total enzyme appearance of creatine-phosphokinase is significantly lower in patients treated with beta-blocking drugs early in the course of of myocardial infarction (within four hours following onset of acute symptoms) as compared with untreated controls. Furthermore the number of ventricular ectopic beats and the severity of chest pain are reduced. In some studies there was a significant reduction in mortality for selected groups of patients with myocardial infarction treated with beta-blocking agents. In conclusion, beta-adrenoceptor blocking agents appear to represent a promising therapeutic principle for protecting ischemic myocardium in acute infarction. Additional investigations are urgently necessary to clarify the question of which patients may profit from such management. Pending the results of such studies, a general recommendation for the treatment of myocardial infarction with beta-blockade can not yet be given.

Acute Disease↗
PubMed1981

The effect of the supra-alveolar soft tissues on the relapse of orthodontic treatment. I. Surgical procedure minimizing the possible influence of the gingival soft tissues on orthodontic treatment relapse.

This is the first of three reports in a study of the effect of the supra- alveolar soft tissues on orthodontic relapse. A surgical method is presented, the object of which is to remove most of the interdental soft tissues without permanent damage to the gingiva or the other parts of the periodontium. A marginal incision is made buccally and lingually in the gingival sulcus in the area concerned. The edge of the wound is folded away from the teeth with a raspatory (Fig, 2). The portion of the papillae remaining between the teeth is excised (Fig 3). The edges of the wound are approximated with sutures placed interdentally (Fig 4). The surgical wound heals with complete regeneration of the interdental papillae (Figs. 6 and 9).

Adolescent↗