Search PubMed⌕ Search

Biomedical subjects

G Opelz

Publications and source records attributed to G Opelz.

At least 343 records · Page 19Linked to original sources
PubMed1977

Studies on the strength of HLA antigens in related donor kidney transplants.

From a study of 3,171 related donor kidney transplants several points of interest emerged: 1. HLA-identical sibling transplants survive at a rate of approximately 85% at 1 year, regardless of whether two, three, or four HLA antigens are identified. 2. Offspring donor transplants survive at similar rates, regardless of whether the recipient is a mother or a father. 3. Transplants from uncles or aunts survive at similar rates as parental donor transplants. 4. Non-HLA antigens contribute approximately 15% to the 1-year kidney transplant failure rate. 5. The strength of an HLA haplotype is reflected in a difference of approximately 15% in the 1-year graft survival rate. 6. The strength of a single HLA antigen contributes about 4% to the 1-year graft survival. 7. The HLA-A or -B loci and antigens of different HLA specificities are roughly of equal immunogenicity. 8. The relative strength of HLA antigens in human kidney transplants is best shown in the well controlled situation of related donor grafts.

Female↗
PubMed1977

Relation between HLA-DW and the b-lymphocyte specificities.

Homozygous DW typing cells were tested for six B-lymphocyte specificities. All four of the second locus specificities of B lymphocytes were strongly associated with the DW specificities. DW1 typing cells were B group 6, DW2 were B4, DW3 were B5, and LD107 were B3. The first B-cell locus antigens 1 and 2 tended to be uniform within the DW groups. From an analysis of the typing responses of a panel of cells to the homozygous typing cells, it has become apparent that the first B-locus specificity present on the homozygous typing cells also plays a role in determining whether a typing response is obtained or not. Thus, the DW3 typing cells were themselves B2 and B5, and cells having B2-B5 were most frequently nonreactive to DW3 in mixed lymphocyte culture. Homozygous typing cells therefore mainly detect the second B-cell locus antigens and, to a lesser degree, the first locus specificities. Stated another way, homozygous typing cells do not define a single specificity, but rather the presence of two B-lymphocyte specificities, even though their responses often reflect matching of only the second B-locus specificity.

B-Lymphocytes↗
PubMed1977

HLA determinants in chronic active liver disease: possible relation of HLA-Dw3 to prognosis.

Thirty-eight patients with severe chronic active liver disease (CALD) were found to have a significantly higher frequency of HLA-Dw3 (68%) than 91 healthy controls (24%) (P less than 0;0001). The association of CALD was statistically significantly stronger with the D locus than with the B locus of HLA. The response to treatment was significantly worse in patients with HLA-Dw3 than in patients who lacked this antigen.

Adult↗
PubMed1977

The association of HLA antigens A3, B7, and DW2 with 330 multiple sclerosis patients in the United States.

Reported associations of HLA antigens with MS have varied considerably. In this study we have examined 330 clinically definite MS patients from the United States. The frequency of DW2 (52%) was highly statistically significant in MS patients as compared to controls (p less than 0.00001). Neither A3 nor B7 was significantly increased in MS; however, the joint occurrences of A3-DW2 (20% vs 7%, p less than 0.001) and B7-DW2 (30% vs 13%, p less than 0.0002) are highly associated with MS.

Chromosome Mapping↗
PubMed1977

Sensitization against non-HLA antigens following bone marrow graft rejection.

A patient with severe aplastic anemia rejected consecutive bone marrow transplants from two HLA-identical sibling donors. Following rejection, the patient developed antibodies that reacted strongly against donor lymphocytes in the complement-dependent cytotoxicity assay. Whereas the reactivity was initially directed specifically against the first marrow donor, cells of both donors and most unrelated individuals were killed by sera obtained after the second injection. These sera were also cytotoxic to the patient's own pre-transplant cells but not to her autologous post-transplant lymphocytes.

Adult↗
PubMed1977

Lymphocyte abnormalities in ankylosing spondylitis.

Peripheral blood T (SRBC rosette) and B (AgG- and C-receptor) lymphocyte subpopulations and responsiveness to phytohaemagglutinin (PHA) were assayed in 40 patients with ankylosing spondylitis and in 55 normal subjects. There was no significant difference in the lymphocyte concentrations or responsiveness to PHA between the two groups. However, the percentages of T lymphocytes were significantly lower in the patients irrespective of their HLA typing. This was probably due to an increase in the 'null' population since the percentages of both the AgG- and C-receptor cells were normal.

Humans↗
PubMed1977

Calculations on long-term graft and patient survival in human kidney transplantation.

Long-term survival rates of human kidney transplants were found to decline at constant rates following the second year after transplantation. The slopes of decline were statistically significantly different for cadaver, parent-to-child, and HLA-identifical sibling transplants, resulting in graft survival half-life times during the constant risk phase of 7.5, 11, and 34 years, respectively. The corresponding patient survival half-life times were 12, 19, and 36 years, respectively. A highly significant difference in long-term survival risk was found when seven transplant centers that had been selected on the basis of their good 1-year graft survival results were compared with seven centers known to have a poor 1-year survival rate. The cadaver graft half-life times during the constant risk phase were 3.3 years for the "poor" centers and 8.7 years for the "good" centers. Thus, although histocompatibility obviously is a main factor in determining long-term survival risk, additional factors such as clinical treatment regimen appear to be influential. Knowledge of the long-term risk constants for the different transplant categories can be applied for the projection of success rates as well as retransplant and dialysis needs.

Cadaver↗
PubMed1977

The role of B-lymphocyte antigens in MLC stimulation.

A total of 950 MLC combinations were set up out of which 259 were classified as low MLC response. An attempt was made to predict which of the combinations would give low response by matching the B-lymphocyte specificities and the HLA-A and -B antigens. A statistically significant prediction of a low response was noted for the B-lymphocyte specificities as well as for HLA-A and -B antigens. The fraction of the low response, which was correctly found, was, however, greater with the B-cell specificities than the HLA-A and -B locus antigens. It is concluded that the B-lymphocyte specificities may be either identical or closely linked to the DW specificities. To what extent they are associated with the strong transplantation antigens of man remains to be determined.

B-Lymphocytes↗