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Biomedical subjects

G Opelz

Publications and source records attributed to G Opelz.

At least 361 records · Page 20Linked to original sources
PubMed1976

Autoimmune panleukopenia.

A patient with episodic panleukopenia involving neutrophilic granulocytes, monocytes and lymphocytes had recurrent bacterial infections and a circulating cytotoxin that injured primitive myeloid cells as well as differentiated granulocytes and mononuclear cells. The cytotoxin was an immunoglobulin with activity against mouse, as well as human, myeloid stem cells. Clinical remission during cyclophosphamide therapy was associated with disappearance of the circulating leukocytotoxin. Serum from a period of active disease was cytotoxic for the patient's own lymphocytes obtained during clinical remission. Absorption of cytotoxic serum with granulocytes removed activity against both granulocytes and lymphocytes. These studies suggest an autoimmune disease in man characterized by episodic granulocytopenia, monocytopenia and lymphocytopenia due to humoral antibody against non-HLA antigens shared by several hematopoietic cell lines.

Adult↗
PubMed1976

Multiple sclerosis and high incidence of a B lymphocyte antigen.

Multiple sclerosis patients were tested for six new antigens present on human B lymphocytes. The group 4 specificity occurred in 83.9% of the 56 patients as compared to 32.5 percent in 72 healthy controls (P less than .003). The antiserums defining the five other B lymphocyte specificities reacted at a lower frequency to B cells from multiple sclerosis patients, showing that increased reactivity to group 4 antiserum was specific. Linkage of a hypothesized multiple sclerosis susceptibility gene with certain haplotypes of HLA-A3, HLA-B7 HLA-DW2, and the new B group 4 can be inferred.

Alleles↗
PubMed1976

Successful renal allografts across a positive cross-match for donor B-lymphocyte alloantigens.

Seven patients received a renal allograft with negative standard and T-lymphocyte microlymphocytotoxicity cross-matches, but a positive B-lymphocyte cross-match using donor lymphocytes. In spite of this presensitisation, none underwent hyperacute rejection and all are functioning from one and a half to six months after transplantation. This procedure may help in the detection of false-positive cross-matches and possibly in detection of enhancing antibodies against a specific donor.

B-Lymphocytes↗
PubMed1976

Defective T cell function in atopic dermatitis.

The cellular immune system of 37 patients with atopic dermatitis (AD) was assessed by measuring peripheral blood T and B cells and the in vitro lymphocyte response to graded doses of phytohemagglutinin (PHA) (background and 6 concentrations of PHA from 100 to 1.6 mug). These were then correlated with clinical severity, ecosinophil counts, and serum IgE levels. The IgE levels (1,482 IU +/- 252 SEM), eosinophil counts (977 +/- 143), and absolute number of B cells (958 +/- 123) were significantly (p less than 0.05) higher than in age-matched controls (70 IU +/- 28, 182 +/- 79, and 480 +/- 60, respectively), and each significantly (p less than 0.05) correlated with the clinical severity. By contrast, percent B lymphocytes (20 +/- 1), percent (51 +/- 2) and total (2,357 +/- 217) T cells did not differ from controls. Eleven patients had low percent T cells (less than 40%); clinical and laboratory evaluation in these patients did not differ from the remaining 26. Lymphocytes from AD patients had higher background deoxyribonucleic acid (DNA) synthesis than controls (suggestive of increased number of B cells) and significantly depressed responses at the low PHA concentrations (6.3, 3.1, and 1.6 mug), which significantly correlated (p less than 0.05) inversely with IgE levels. These studies suggest a subtle defect in T lymphocyte function leading to increased B cells and increased IgE production.

Adolescent↗
PubMed1976

Hypersensitivity to procarbazine associated with angioedema, urticaria, and low serum complement activity.

Hypersensitivity to procarbazine associated with urticaria, angioedema, and painful joint swelling was found in a 20-year-old student being treated for Hodgkin's disease. A marked fall in complement component activity occurred simultaneously with the development of symtoms. It is suggested that generation of products of complement component activation could be important in the pathogenesis of hypersensitivity to some drugs.

Adult↗
PubMed1976

Intact humoral and cell-mediated immunity in chronic marijuana smoking.

The immune system of 12 healthy chronic marijuana-smoking adults was evaluated while they smoked marijuana daily for 64 consecutive days under controlled hospitalized conditions. Studies included enumeration of B and T cell subpopulations, lymphocyte proliferative responses to PHA and to allogeneic cells, and serum immunoglobulin levels. Percent B cells, initially low in 2 patients, became normal. Baseline total B cells, determined either by surface immunoglobulins (338 cells/mm3 +/- 60 SEM) or complement receptors (162 cells/mms +/- 27) were significantly (p less than 0.05) less than control but increased to normal (485 +/- 97 and 239 +/- 47) over time. Percent T cells, initially low (less than 40%) in 4 patients, became normal. Baseline T cells (951 cells/mm3 +/- 70 SEM), significantly lower than controls (2,010 +/- 210, p less than 0.05), increased to normal by day 63 (1,875 +/- 281). In vitro lymphocyte response to graded doses of PHA and to allogeneic cells was normal initially and did not change over time. Serum IgG (1,064 +/- 33), IgA (166 +/- 13), and IgM (96 +/- 6) were normal. Serum IgE levels increased in 4 subjects without evidence of allergy. Short-term chronic marijuana use does not have a substantial adverse effect on B or T cells of young healthy adults.

Adult↗
PubMed1976

Recipient selection for renal retransplantation.

Analysis of over 1,000 kidney retransplants revealed an important effect of first graft duration and presensitization on graft outcome. Second cadaver donor grafts into patients without preformed cytotoxic antibodies and a first graft duration of more than 12 months survived at a high 1-year rate of 71 +/- 6%, in contrast to 29 +/- 6% in those whose first graft had failed in 1-3 months (P is less than 0.0001). Third or fourth transplants into patients with preformed cytotoxins survived at the poor rate of 17 +/- 6% at 1 year. To repeat all HLA mismatches from the first graft was found to result in decreased second graft survival.

Cadaver↗
PubMed1976

Prolongation effect of blood transfusions on kidney graft survival.

Transfusion data were collected during a 3-year period on 382 hemodialysis patients with the aid of a computerized followup system. Thirty-seven per cent of the patients did not receive any blood transfusions prior to transplantation. The graft survival in nontransfused patients was statistically significantly lower than that in transfused patients. These results confirm our previous findings in an independent series of patients.

Blood Transfusion↗
PubMed1976

Absence of specific mixed leukocyte culture reactivity during graft-versus-host disease and following bone marrow transplant rejection.

Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In tests of pre-and post-transplant lymphocytes we found no evidence that rejection or graft-versus-host disease was caused by antigens that stimulate in the mixed lymphocyte culture assay.

Bone Marrow Cells↗
PubMed1976

HLA antigen studies in a family with C2 deficiency.

Two children in a family were found to be homozygous for C2 deficiency; both parents and a third child were heterozygous. C2 deficiency was associated with the HLA haplotypes carrying the antigens B18 and DW2. Antigen A10 was absent in this family. Mixed lymphocyte culture studies among the family members confirmed the association of C2 deficiency with the HLA-D locus.

Adult↗
PubMed1976

Kidney preservation: perfusion versus cold storage-1975.

In order to compare the efficacy of simple hypothermic preservation of cadaver kidneys in Collins solution with preservation by pulsatile perfusion, data were gathered on over 1000 transplants between December 1973 and June 1975. In this series of new patient data, it was found that the 1-year thansplant survival rate of 59%+5% in 89 kidneys preserved in Collins solution was significantly better than the 41% + 3% rate found with 358 kidneys preserved by the Belzer machine (p = 0.005). This survival rate was better than the 47% + 3% rate in 421 kidneys preserved on the Waters machine (p = 0.05), and the 34% + 6% rate of 97 kidneys preserved by cold storage in Sacks solution (p = 0.005). The difference in centers probably did not influence the data, since 28 centers submitted data on the Collins-preserved kidneys. In addition, 43 of the 89 kidneys. In addition, 43 of the 89 kidneys stored in Collins solution had been shared between centers.

Cold Temperature↗
PubMed1976

Frozen blood transfusions and renal allograft survival.

It has been shown that kidney transplant graft survival rates were lower among nontransfused patients than among those receiving transfusions. In a relatively small series of 49 patients who received frozen blood only the 1 year transplant survival rate was 42+/-7% as compared to 49+/-5% in 190 patients with whole blood transfusions and 31+/-4 in 143 patients with no transfusions. We conclude that frozen blood transfusions appear to be better than no transfusions, but may be inferior to whole blood in prolonging graft survival.

Blood Transfusion↗