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Biomedical subjects

G Nagy

Publications and source records attributed to G Nagy.

At least 217 records · Page 12Linked to original sources
PubMed1980

Modified radial-plaque-neutralization test for demonstration of enterovirus neutralizing antibodies.

A simple radial method based on the formerly described paper disc technique was developed for demonstration of neutralizing antibodies to enteroviruses with plaque forming ability. Sera administered by 5 microliter wire-loops to wells cut into the agar overlay of virus infected cell monolayers produced radial neutralization zones with a size directly related to their specific antibody contents. Results of poliovirus neutralizing antibody tests performed by the radial plaque neutralization method were found to be in a good agreement with those obtained in antibody titrations either in monolayer tube cultures or in microtitre system. The relatively simple technique makes possible to investigate several hundreds of serum samples in a single experiment, so it is especially suitable for use in expanded serological surveys. It proved to be useful also for identification of enteroviruses and for testing the laboratory strains for identity.

Antibodies, Viral↗
PubMed1980

[Effects of intrapartum steroid prophylaxis on complement C3 and total complement activities (author's transl)].

One single high dose of dexamethasone (0.5 mg/kg body weight) was administered to a mother, before tests started into the effects of such approach upon the serum total complement (CH 50) and C-3 levels in the mother's umbilical cord blood. Neither CH 50 nor C-3 complement had declined with significance 48 hours from steroid administration. Significant reduction was observed only in cases in which six hours elapsed between steroid administration and childbirth.

Complement C3↗
PubMed1980

[Variation in cellular immunity - its bearings on effectiveness of steroids used during labour (author's transl)].

Thirty-five mothers and their newborns were examined for immunosuppressive effects of dexamethasone administered during labour (0.5 mg/kg body weight). Decline of both active and total t-cells was recorded from the mothers (p < 0.5; p < 0.01). No deviation was recordable from b-cells. The ratio of t-cells, b-cells, and O-cells in premature and full-term newborns was reduced to something below the values obtained from control groups. The difference, however, was not significant.

B-Lymphocytes↗
PubMed1979

[Electrolytes in the CSF of hydrocephalic patients (author's transl)].

The concentrations of Na+, K+, Cl-, Ca++, and Mg++ were measured in the CSF and serum of controls and in those of patients with hydrocephalus. Hydrocephalus was proved with pneumoencephalography. The amounts of Na+, K+, Ca++, and Mg++ were significantly higher in the CSF of patients with hydrocephalus than in the CSF of controls. The changes in the electrolyte concentration gradients seem to indicate that it is not the blood-brain barrier but the brain-CSF barrier which is disturbed in hydrocephalus.

Adolescent↗
PubMed1979

[Detection of the RDS risk from postnatally sampled stomach contents].

The results of foam tests carried out on postnatal stomach contents from 267 neonates were analyzed to see whether a correlation can be found between the incidence of RDS and the foam-test values. The test proved to be a good indicator in the recognition of RDS. If ++, + positive, on negative foam-tests are obtained development of RDS can be expected in about 60% of the cases. By this quick and simple test neonates with the risk of RDS can be screened off and transported in time to centres of intensive care.

Birth Weight↗
PubMed1979

[Studies into aetiology of hyaline membrane disease (author's transl)].

The courses of gestation were re-examined of 171 newborns who had died of hyaline membrane disease. Premature births accounted for 91.81 per cent of the cases reviewed, while 73.24 per cent had undergone gestation between 28 and 32 weeks of pregnancy. Premature placental detachment, hydramnion, and twin pregnancy were among the major factors contributive to gestational complications. Perinatal asphyxia played a substantive role in 53.21 per cent of all cases under review. In newborns delivered on term the development of RDS was in almost all cases attributable to acidosis. Early complications were analysed for newborns involved in steroid prophylaxis. The frequency of cerebral haemorrhage was nearly identical with findings recorded from a control group. A significant difference was not even recorded from cases of inflammatory complications.

Abruptio Placentae↗
PubMed1979

[Lecithin-sphingomyelin ratio "its prognostic importance to pregnancy" of diabetics (author's transl)].

The lecithin-sphingomyelin ratio was determined by the authors, applying Gluck's technique to 98 amniotic fluid samples of 55 pregnant patients with diabetes, depending on gestational age. Amniocentesis was preceded by ultrasonic placentography. Carbohydrate metabolism of this group was kept under optimum management and regulation. Its L/S ratio (3.1) was twice as much as that recorded from another group of patients (1.5) without adequate management of the carbohydrate metabolism. The rate of complications in the first group was below that in the second. -- It has been emphasised by the authors that variation in the L/S ratio along with gestational age depended not only on the severity of the given course of diabetes but, as well, on the management of the carbohydrate metabolism during pregnancy. They found that in any pregnancy under the conditions of diabetes the L/S ratio was an important criterion for diagnostic assessment of foetal lung maturity.

Amniotic Fluid↗
PubMed1979

Absorption of colostral immunoglobulins in suckling piglets.

The three portions of the small intestine of 18 neonatal piglets were examined by using the so-called scroll technique evolved by the authors and in cross sections. The chemical constitution and the immunoglobulin content of undigested protein droplets being under absorption were studied. An intensive absorption of immunoglobulins was demonstrated in the body of each cuticulated cylindric epithelial cell of the mucosa covering the jejunum and the proximal two-third of the ileum. Absorption was the most intensive, though variable by area, in the jejunum. It was demonstrable 4 hr after birth and reached the highest intensity between 8 and 12 hr, then tended to decline. In the protein droplets alpha-amino acids, neutral mucopolysaccharides and protein-bound Ca2+ were detected. Alkaline phosphatase activity was demonstrated around the droplets. Immunofluorescence and immunoperoxidase reactions proved the presence of immunoglobulins, first of all of IgG, in droplets. Electron microscopically, the microvilli of the involved epithelial cells were swollen, sometimes neighbouring ones were pushed away from each other; in the same areas, an electron-dense substances (colostrum) covering the enterocytes was streaming through the tubulovascular network of cells to the perinuclear region, where it appeared in spherical droplets.

Animals↗
PubMed1979

[Different labour behaviours following induction, using oxytocin and prostaglandin F2 alpha (Enzaprost) (author's transl)].

The authors studied the characteristics of labour induced by means of prostaglandin (Enzaprost F). The results were compared to spontaneous childbirths and to labour induced by means of oxytocin. Increased basal tension of the uterus and higher amplitude of uterine contractions were recorded from the prostaglandin group. Contractions were also analysed for variations in shape. Deformation in response to oxytocin was found to be almost identical to that following prostaglandin. Atypical contractions were found to occur more often in women in whom labour was induced for risk to the foetus and in primiparae, though the number of third-type contractions was lower in such cases. The point is made that betamimetics may be very helpful in getting to grips with incoordinate uterine activity. They were found to stop irregular uterine activity, and re-induction then will be accompanied by regular rhythmicity of labour.

Adult↗
PubMed1979

[The effect of some non-narcotic analgetics on respiration (author's transl)].

Report on a Hungarian analgetic "Probon" belonging in its effects to the minor analgetics. It does not show any depressing action on the respiratory centre and has a bronchodilatory effect. It does not cause sideeffects nor dependence and does not lose in efficacy even in long lasting application and in old people.

Bronchodilator Agents↗
PubMed1978

Study of pancreatic tissue pH in the early stage of experimental acute pancreatitis.

Pancreatic pH was measured electrometrically over a period of 3 h in 34 dogs with acute necrotic pancreatis. The disease had been induced with sunflower oil in 10, with Na-taurocholate in 10 and with hen's egg yolk in 10 animals. Four dogs served as controls. The pH of the pancreatic tissue changed differently in the different groups, in accordance with the different pathomechanisms. Injection of sunflower oil was followed by a protracted acidosis of pancreatic tissue, that of taurocholate by a transitory moderate decline of pH. Egg-yolk produced an evanescent, slight fall in pancreatic pH, followed by complete normalization within a few minutes. The differences between the initial and the 3-h values attain the level of significance only in case of sunflower-oil pancreatitis.

Acute Disease↗