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Biomedical subjects

G Nagy

Publications and source records attributed to G Nagy.

At least 199 records · Page 11Linked to original sources

Carcinoid tumours of the rectum.

Carcinoid tumours of the rectum occur relatively seldom. The personal experience was 11/20,0000 rectoscopies. The symptoms are not characteristic. Such tumours can mostly be detected by chance. The basic diagnosis can only be achieved through thorough histological examinations. The tumours are usually not larger than 1 1/2 cm in diameter. Usually are restricted to the mucosa and submucosa, are solitary and can be treated perfectly with endoscopic excision. In case the tumour either invades the muscular layer, reaches or exceeds the diameter of 2 cm, or occurs in a multiple form a radical surgical approache is needed, resection should be performed.

Adult↗

A new type of enzyme electrode: the ascorbic acid eliminator electrode.

A new type of enzyme electrode has been developed for in vivo electrochemical measurements which allows discrimination between ascorbic acid and catecholamines and their metabolites. The electrode employs the enzyme ascorbic acid oxidase held between the voltammetric electrode and solution by a dialysis membrane or immobilized on the outer surface of serous membrane from rat small intestine. The electrode gives linear calibration curves for all catecholamines and metabolites independent of any ascorbic acid concentrations significant in physiological measurements. The electrode has been tested in brain slice measurements and shown to respond to releases of catecholamines initiated by potassium ion stimulation.

Animals↗

Effect of naloxone on the suckling induced prolactin release in rats.

2.0 mg/kg b.w. of naloxone--a specific opiate antagonist--injected i.p. 10 min before a brief (lasting for 10 min) suckling and 10 min before a second suckling 30 min after the first suckling significantly inhibited the rise in plasma prolactin levels induced by the suckling stimuli. 0.2 mg/kg of naloxone caused only a slight inhibition on the pituitary prolactin response, the inhibitory effect being more evident on the response to the second suckling stimulus. The data are consistent with the view that endogenous opioids might be involved in the control of prolactin secretion of lactating rats.

Animals↗

Colitis carcinoma in ulcerative colitis.

During the period from 1963 till 1981 altogether 342 patients suffering from ulcerative colitis were treated. In their material authors found 6 patients (1.7%) who achieved cancer of the colon beginning 7, 9, 14, 18, 18 und 21 years after the onset of ulcerative colitis symptoms. According to the clinical data their ulcerative colitis could be considered to belong to the severe or the moderate type. From the anatomical point of view the extension of the process exceeded the sigmoid colon in all but one. Respecting the clinical course of the disease, malignant transformation took place in 3 patients of the relapsing-remitting type, in 2 instances the clinical course could not be classified, the sixth case proved to the chronic continuous type. Colonic tissue was gained and diagnosis stated with traditional methods within 4 instances, while in 2 it was gained from tissue specimens passing through the stool. In 3 cases the tumour was multiple. From the morphological point of view the features had a plaque form in 2 cases, a polypous nature in other 2 cases, while among each one patient a fibrous stricture and ordinary colorectal cancer occurred. The tumour was identified as well differentiated and poorly differentiated adenocarcinoma in identically 3 instances. All the patients underwent an operation, only one of them is still alive. In sake of detecting colitis carcinoma earlier, they suggest yearly endoscopic and biopsy survey of ulcerative colitis patients.

Adult↗

The prostaglandins.

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Chemical Phenomena↗