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Biomedical subjects

G Moulin

Publications and source records attributed to G Moulin.

At least 181 records · Page 10Linked to original sources
PubMed1984

Characterization of beta adrenergic receptors in bovine pigmented ciliary processes.

To analyse the molecular mechanism of action of beta-adrenergic compounds in reducing the intraocular pressure, the binding of 125I-iodohydroxybenzylpindolol to bovine pigmented ciliary processes was studied. The binding was found to be highly specific, saturable, reversible and displayed stereospecificity. Only one class of binding sites was detected. Values for KD of 0.18 nM and 0.32 nM were derived from kinetic and equilibrium experiments, respectively. The total number of beta receptors was large : 1.28 pmoles/mg protein. Competitive inhibition of 125I-iodohydroxybenzylpindolol binding by agonists and antagonists revealed that the majority of beta receptors in bovine pigmented ciliary processes were of the beta 2 type. The pharmacological and biochemical characteristics of the binding of adrenergic drugs found in these membranes are consistent with a regulation of aqueous humor production by the beta adrenergic system.

Adrenergic beta-Agonists↗
PubMed1984

[Fixation of antibodies by covalent bonds to polystyrene: use of the immunoenzyme technic for the detection of Escherichia coli K99 in calf feces].

A solid phase enzyme immunoassay using antibodies covalently bound to polystyrene balls is developed. Results show the same sensitivity as the method with antibodies adsorbed to solid support. By means of K99+ E. coli detection on diarrhoeic calves, results are compared with bacteriological findings. The interest of the method is discussed.

Animals↗
PubMed1984

[Familial Degos' atrophic papulosis (mother-daughter)].

Degos' disease (malignant atrophic papulosis) occurring in mother and daughter is described. Mother's eruption is composed of multiple characteristic lesions (up to 600). She does not have any gastrointestinal, neurological nor other visceral manifestations after a 9-year course. One year after the onset of the disease, she had a daughter. The pregnancy was normal and the newborn did not have any cutaneous manifestation. The daughter's first skin lesion appeared when she was 3-months old. She has now been under observation for nearly nine years and developed only four skin lesions without any visceral manifestation. Laboratory investigations show an increase in fibrinogen in both mother and child, without any sign of disseminated intravascular coagulation. The research for "slow virus" by a primate's intravascular inoculation of mother's skin lesion in negative.

Adult↗
PubMed1983

[Detection of Escherichia coli K99+ in the feces of cows and their calves].

Enteropathogenic antibiotic resistant E. coli (K99+, ST+) were selected and numbered in the faeces of cows and their newborn calves from a farm where outbreaks of neo-natal diarrhoea occurred occasionally. K99+ E. coli were resistant to nalidixic acid. This resistance rarely encountered, enabled to number selectively these bacteria. In the eight affected calves, the K99+ strains were simultaneously resistant to nalidixic acid, ampicillin, streptomycin, kanamycin, chloramphenicol, tetracyclines and sulphonamides. In the cases of severe diarrhoea, these K99+ E. coli predominated in the faecal flora. Strains presenting the same characters were also isolated from the faeces of the mothers, where they were generally found in lesser numbers. When calves were prophylactically treated with gentamicin or when their mothers had been vaccinated against enteropathogenic E. coli, clinical signs of diarrhoea did not appear or were mild, but carriage of K99+ E. coli persisted. These first results contribute to a better understanding of the epidemiology of neonatal colibacillosis in calves.

Animals↗
PubMed1983

[Treatment of Jessner-Kanof disease with thalidomide].

Five patients present a Jessner-Kanof's lymphocytic infiltration of the skin with 6-year duration for 4 of them. The skin lesions are numerous on the face and the back and characteristic of this disease. Histologic examination shows a lymphocytic infiltrate in the dermis without any modification of epidermis. Direct immunofluorescent study is negative in all cases. In 3 cases, response to chloroquine had been inconsistent or negative. The 5 cases have a excellent result with 100 mg/day of Thalidomide. In 4 cases the skin lesions reappear when treatment is stopped. With a continuous treatment of 25-50 mg/day for more than 2 years, 3 of 5 patients have normal skin. Thalidomide appears to be the best treatment of Jessner-Kanof's disease.

Adult↗
PubMed1983

[Pseudopurpuric palmar localizations of herpetiform dermatitis].

We report an unusual manifestation of dermatitis herpetiformis in four patients. Three of them fulfill all the criteria for dermatitis herpetiformis: micro-abscesses of polymorphs in the upper papillary dermis, granular IgA deposit on IF examination, gluten-sensitive enteropathy, HLA B8. These peculiar lesions occur on palms and fingers, and appear as a petechial and ecchymotic purpura. A light painful sensation may precede the eruption. In two cases the palmar localisation initiated the course of the disease and remained isolated for more than one year. In only two cases, typical inflammatory lesions were associated on the palms. No lesions occurred on the soles. These peculiar palmar purpura-like lesions cleared with gluten-free diet or Dapsone therapy in the four patients.

Adolescent↗
PubMed1982

[Paget's disease].

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Breast Neoplasms↗
PubMed1982

[O'Brien's actinic granuloma, Three cases (author's transl)].

We report three cases of 54, 58 and 65-year-old patients presenting annular lesions with centrifugal migratory extension. They occur exclusively on sun-exposed areas. In two cases, the lesions were multiple. In the third case, the lesion was single and mimicked an erythema annulare centrifugum. The past history ranged from 18 months to 8 years. Microscopic examination of the central part showed a disappearance of elastic fibers in upper reticular dermis. Examination of the ring showed in upper reticular dermis an histiocytic granulomatous infiltration with many giant cells, lymphocytes and patterns of elastic fibers phagocytosis. Similar features were found by electronmicroscopy. These three cases illustrate the typical features of O'Brien's actinic granuloma. Relationship between this actinic granuloma and granuloma annulare occurring on sun-exposed areas on one side, and necrobiosis lipoidica, Miescher's granuloma and granuloma multiforme on the other side, are discussed. On the basis of some clinical and histological patterns, the autonomy of O'Brien's actinic granuloma appears to be established.

Aged↗
PubMed1982

[The kidney in systemic scleroderma. A report of 38 consecutive cases ].

The renal status of 38 patients with progressive systemic sclerosis (scleroderma) has been investigated by the usual clinical tests, urine electrophoresis, glomerular filtration rate (GFR) and renal plasma flow (RPF) determinations and in 4 cases by renal biopsy. Fourteen patients presented with proteinuria and/or a high serum creatinine and/or hypertension with low clearance values in all cases. In 14 other patients, an abnormality was apparent from clearance results (12 cases), renal biopsy (1), urine electrophoresis (1). The earliest sign of renal involvement that could be demonstrated was a reduced RPF and an elevated filtration fraction. Subsequently, a glomerular proteinuria with a electrophoretic pattern was observed as either the only sign (9 cases) or in association with abnormal clearance values (8 cases). The incidence of clinical renal involvement (proteinuria, renal failure, hypertension) ranged from 16 to 60%; 2/3 of patients who presented with proteinuria and hypertension died within 3 years. A mucoid thickening of intima and a fibrosis of adventitia in the proximal part of interlobar and arciform arteries, a fibrinoid necrosis in the distal part of lobular and preglomerular arteries are distinctive although inconstant features. The vascular lesions (seen in 70% of cases) and superimposed but reversible vasoconstriction, account for the decreased RPF. An effective control of blood pressure is mandatory; the therapeutic value of angiotensin converting enzyme inhibition remains to be corroborated.

Adult↗
PubMed1981

[Pustules].

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Adolescent↗
PubMed1981

A study of amylolytic system of Schwanniomyces castelii.

The amylolytic system of Schwanniomyces castellii cultured on a yeast extract starch medium consists of 3 enzymes: an alpha-amylase (molecular weight 40,000), glucoamylase I (molecular weight 90,000), and glucoamylase II (molecular weight 45,000). The properties of the enzymes and the action of enzyme inhibitors were determined.

Amylose↗