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Biomedical subjects

G Kaiser

Publications and source records attributed to G Kaiser.

At least 163 records · Page 9Linked to original sources
PubMed1978

Effects of Mg2+, Mn2+ and Ca2+ on adenylcyclase activity. Evidence for a metallic site.

In membrane preparations from immature erythrocytes from rats the effects of the divalent cations Mg2+, Mn2+ and Ca2+ on basal activity of adenylcyclase as well as on enzyme activity stimulated by isoprenaline (Ipn) or guanylyl-imidodiphosphate [Gpp(NH)p] were investigated.--Mn2+ is a ten-fold stronger activator of the enzyme than Mg2+ irrespective of the stimulant used. At suboptimal concentrations of the cations at all concentrations of Gpp(NH)p used (10(-6) to 10(-3) M) reaction velocities increase progressively over an incubation period of 40 min. Optimal cation concentrations, however, i.e. 3 x 10(-3) M Mn2+ and 3 x 10(-2)M Mg2+ elicit a constant and at 10(-4) M Gpp(NH)p maximal reaction velocity. In contrast, the Ipn-stimulated cAMP synthesis proceeds linearly at all Ipn concentrations used; a change of cation concentrations elicits only a change in reaction velocity, which is maximal at 10(-3) M Mn2+ and 10(-2) M Mg2+ respectively.--Ca2+ inhibits adenylcyclase activity in a non-competitive manner, irrespective of the stimulant and ion concentration used. The Mg2+-activated enzyme, however, is more susceptible to the inhibiting effect of Ca2+ than the Mn2+-activated enzyme.--It is concluded that Mn2+ and Mg2+ are allosteric effectors of the enzyme adenylcyclase, acting at a Me2+-site of the catalytic unit of adenylcyclase.

Adenosine Triphosphate↗
PubMed1978

Protein-losing enteropathy due to segmental erosive and ulcerative intestinal disease cured by limited resection of the bowel.

Two children suffering from extensive intestinal protein loss due to subacute and chronic segmental small bowel disease are presented. In the first case a tentative diagnosis of chronic erosive and ulcerative non-granulomatous jejunitis as described in adults was made. The second child suffered from subacute erosive and ulcerative segmental transmural ileitis following mechanical ileus. In both instances resection of the involved segments of small intestine promptly cured the enteric protein loss. It is suggested that excessive protein loss due to subacute or chronic segmental erosive and ulcerative intestinal disease may be cured definitively by surgical resection. An explorative laparotomy should be performed if broad internistic investigations do not provide an explanation for the severe and prolonged enteric protein loss.

Adolescent↗
PubMed1977

Valve replacement in children.

Since 1964, 27 valve replacements have been performed in patients who ranged from 5 months to 20 years of age. Fourteen underwent aortic valve replacement, 10 underwent mitral valve replacement, two had systemic atrio-ventricular valve replacement, and one had tricuspid valve replacement. Nineteen patients had congenital heart disease, five had rheumatic disease, and three had Marfan's syndrome. Starr-Edwards prostheses were used in 17 patients, Björk-Shiley prostheses in six, and procine xenografts in for. There were five early deaths and five late deaths. Patients were followed for 2 months to 6 years postoperatively (mean 2.1 years). All survivors showed clinical improvement. There were no episodes of thromboembolism. Minor bleeding, arrhythmias, and bacterial endocarditis occurred infrequently.

Adolescent↗
PubMed1976

Monoamine oxidase activity in rat erythrocytes: evidence for its localization in reticulocyte mitrochondria.

During growth of young rats, monoamine oxidase activity in erythrocyte membrane preparations decreases more rapidly than reticulocyte concentrations in the respective blood samples. Since reticulocytes lose their mitochondria prior to the substantia reticulo-filamentosa, the non-linear correlation between monoamine oxidase activity and reticulocyte counts indicates that erythrocyte monoamine oxidase is located in reticulocyte mitochondria.

Animals↗
PubMed1976

[Q-Fever and its complications (author's transl)].

Q-Fever recurs as localized epidemics in the German Federal Republic. The disease has not previously been observed in North Hesse. During a familial infection with Coxiella burneti a 15-year-old boy together with his parents and an aunt became ill with atypical pneumonia. After the pulmonary symptoms had subsided a deep left leg and pelvic venous thrombosis occurred in the boy in the fifth week after the onset of the disease. The thrombosis which is very rare in childhood could be successfully removed at operation.

Adolescent↗
PubMed1976

[Reflections on the anorectal pressure profile].

The results of electromanometric studies of the anorectum in 40 children are presented. Owing to a constant flow of rinsing water through the recording tube and owing to a repeated tracing during the same session, there is a more sensitive picture of the anorectal pressure profile than reported hitherto. In addition, the anorectal pressure values are higher. In healthy infants and in most children with constipation and/or encopresis, the anorectal pressure profile can be divided in 2 different parts. These can be differentiated by their amplitude and according to their shape. In a few patients with constipation, there is no difference between the two parts concerning the shape of the anorectal pressure profile, and the values of the anorectal pressures are below normal. But all children with anal sphincter incontinence have a distinctively abnormal anorectal pressure profile, there is not even a numerical difference between the two parts of the anorectal pressure profile, and the anorectal pressures are very low. The relationship between these two parts of the anorectal pressure profile and the muscles of the pelvic floor are discussed and the significance of the mentioned technique evaluated with regard to the diagnosis and treatment of the anorectal disturbances in childhood.

Anal Canal↗