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Biomedical subjects

G Kaiser

Publications and source records attributed to G Kaiser.

At least 145 records · Page 8Linked to original sources
PubMed1980

[Regeneration in bony defects after implantation of resorbable calcium phosphate ceramics. A comparative clinical study].

After experimental demonstration of the excellent tissue tolerance with ceramics-bone contact without connective tissue in animals and because of the good resorbability of tri-calcium phosphate ceramics (TPC), TPC ceramics was used in a clinical study to fill the bony defects resulting from apicectomies and cystectomies. The patients were controlled for a period of up to six months. After an initially normal healing phase, an unusually high rate of late complications with fistula formation and rejection of the TPC ceramics was observed around the tenth postoperative week. Possible causes for these late complications were discussed.

Apicoectomy↗
PubMed1980

Cellular immune function in patients with cancer of the upper part of the gastrointestinal tract.

Lymphocytes of 30 patients were examined for cellular immune function one day prior to operation. In 11 patients the tests were repeated six weeks after surgery. In comparison with 26 healthy blood donors the E rosette values were strongly reduced in the patients group. The zymosan-complement rosette counts were significantly lower if percentages were compared, but not significant when they were expressed in absolute numbers. Lymphocyte transformation tests revealed significant differences between the patients and control cases with all three mitogens applied (PHA, ConA, PWM). In the 11 patients with the tests repeated after operation, the effect of autologous plasma on the cultures was also studied. The main tendency was inhibition but in some cases the patients' plasma enhanced the reaction. Killer cell activity by ADCC was significantly lower in patients' than in the healthy donors' lymphocytes in different target-effector cell ratios.

Animals↗
PubMed1979

[Continuous monitoring of intracranial pressure and new aspects of neurologic intensive care for children].

A new concept of neurointensive care is presented which is based on earily measured parameters such as intracranial pressure (ICP), mean arterial pressure (MAP) and cerebral perfusion pressure (CPP) (CPP = MAP - ICP). ICP should preferably be measured by a subarachnoid hollow screw (Richmond screw). Of chief importance in neurointensive care (after adequate neurodiagnosis) is the avoidance or treatment of cerebral edema and maintenance of sufficient CPP, which should be above 50 mm Hg in older children. This is achieved by controlled hyperventilation under curare, generous oxygenation, control of body temperature, dexamethasone and possibly barbiturates in very high doses (phenobarbital and thiopentone). This kind of neurointensive care should be administered in all types of severe CNS accidents which are followed by substantial cerebral edema (head injuries, near drowning, Reye's syndrome, hypoxic encephalopathy, encephalitis, meningitis and intracranial bleeding). To obtain the indication for ICP monitoring, the depth of the disturbance of consciousness is measured by the Glasgow Coma Scale. Children with the aforementioned affections and a Glasgow Coma Scale below 6 to 8 should be treated as outlined above. The data published in the literature and our own experience point very much in this direction, especially for severe head injury, Reye's syndrome and near drowning.

Barbiturates↗
PubMed1979

Patients, not unions, first concern of hospitals.

Although the law regarding employee organizational rights in health care institutions has been in a state of flux since 1974, it is now clear that patient care generally takes precedence over employees' rights to organize on hospital premises.

Health Facility Environment↗
PubMed1979

Inversal relationship between basal adenylcyclase activity and maximal degree of stimulation in membranes of red blood cells from rats.

The degree of stimulation of adenylcyclase activity, in membranes from immature red blood cells from rats, brought about by isoprenaline, guanylyl-imidodiphosphate and sodium fluoride is strongly dependent on the basal activity of the enzyme. The inversal relationship between basal activity and the maximal degree of stimulation by (--) isoprenaline, shows an apparent seasonal dependence.

Adenylyl Cyclases↗
PubMed1979

Fibrous dysplasia in the light of new diagnostic methods.

Various screening tests provide a detailed representation of fibrous dysplasia: thermography, scintigraphy, computer tomography, scanning electron microscopy, X-ray microanalysis, microradiography and fluorescence microscopy. The stationary nature of clinical and X-ray findings contrasts with the intensive structural changes that occur. The above-mentioned methods are examined with regard to differential diagnosis.

Adolescent↗
PubMed1979

Problems of diagnosis and treatment in the Dandy-Walker syndrome.

10 children with Dandy-Walker syndrome are presented to discuss their clinical assessment and therapy. The presence on physical examination of a large posterior fossa was the most reliable clinical finding and was diagnostic in 9 out of the 10 patients. The different diagnostic confirmatory studies are discussed. The most satisfactory treatment in this series was the combination of a shunt from the lateral ventricle and the posterior fossa to the peritoneum.

Cerebrospinal Fluid Shunts↗
PubMed1979

Cold blood cardioplegia.

The technique of myocardial protection by means of a cardioplegic solution consisting of cold blood (10 degrees C) with potassium (30 mEq. per liter) is described. A disposable cooling coil is used and a separate pump head for coronary perfusion is avoided. The aortic perfusion cannula can be used for venting of the left ventricle and subsequently for venting of air. This method was used in 125 consecutive patients undergoing coronary revascularization and in 73 consecutive pediatric cardiac surgical procedures with excellent results.

Blood↗
PubMed1978

Direct characterization of beta-adrenoceptors in membranes of immature red blood cells from rats.

By means of the radioactive antagonist ligand (3H)(-) dihydroalprenolol (DHAP) specific binding sites were identified in membrane preparations from red blood cells from rats. These specific sites were characterized as beta-adrenoceptors because of the following reasons: Specific binding of DHAP (in contrast to unspecific binding) was dependent on temperature and time of incubation. Furthermore, specific binding of DHAP showed saturability, temperature-dependent reversibility and high affinity (KD-value of DHAP = 6.51 nM). Specific binding of DHAP was competitively inhibited by beta-adrenergic antagonists (pindolol greater than alprenolol greater than or equal to propranolol greater than practolol) and agonists (isoprenaline greater than adrenaline). The (-) enantiomers of pindolol and isoprenaline showed pronounced higher affinities for the receptor sites than the respective (+) enantiomers. The receptor density in the membrane preparations (pmoles/mg protein) was strongly dependent on the degree of reticulocytosis: The Bmax-values increased more than 4 to 5 fold without alteration of the respective KD-values when reticulocyte counts were enhanced from 3 to 80% treatment of the animals with increasing doses of acetyl phenylhydrazine.

Alprenolol↗
PubMed1978

[The influence of low-frequency DC (system Kraus-Lechner) on bone growth (author's transl)].

Osteons of Beagle-ulnae were calculated in growth. Controlled osteons were compared with osteons after "therapy". Stimulation was made with electro-nails system Kraus-Lechner. The mean-values of osteons after "therapy" surpass control. The fundamental question, whether induction of bone growth occurs with low frequency electromagnetism will in all probability be have to answered in the affirmative.

Animals↗
PubMed1978

[Diagnosis of tuberculosis of the spine (author's transl)].

An analysis is presented of the case histories of 302 patients, admitted with tuberculosis of the spine to the Orthopaedic Department of the University Clinic, Vienna for surgical or conservative treatment. The average time between the onset of pain and the diagnosis was 13 months. Two thirds of the patients had no preceding history of healed or active tuberculosis. The average age of the patients was 40 years. Most of the patients showed tuberculous infection of only two vertebral bodies, mainly affecting the 8th thoracic to the 5th lumbar vertebrae. The diagnosis is made in most cases on the basis of the case history, clinical examination and, in particular, the radiological findings.

Adolescent↗
PubMed1978

Correlation between isoprenaline-stimulated synthesis of cyclic AMP and occurrence of beta-adrenoreceptors in immature erythrocytes from rats.

When increasing reticulocytosis (up to 80%) was induced in rats by treatment with acetyl-phenylhydrazine (up to 70 mg/kg on 3 consecutive days) synthesis of cAMP stimulated by isoprenaline in intact red blood cells and in the related membrane preparations increased up to 100-fold. At the same time the density of beta-adrenoreceptor sites (measured by ligand binding with (3H)(-)-dihydroalprenolol) in the related membrane preparations was only increased about 5-fold. There was however a linear correlation between the increase of isoprenaline-stimulated enzyme activity and the receptor density in membrane preparations. The results indicate that mature red cells contain beta-adrenoreceptor sites but little or not adenyl cyclase activity. Thus, during the maturation process of these cells, enzyme activity and receptor densities decrease at different speeds indicating a different turnover of these two entities of the cytoplasmic membrane.

Adenylyl Cyclases↗