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Biomedical subjects

G Jakse

Publications and source records attributed to G Jakse.

At least 199 records · Page 11Linked to original sources
PubMed1986

Excisional repair of urethral stricture. Follow-up of 90 patients.

One hundred five patients with urethral stricture of various causations were treated with excision of the stricture and oblique end-to-end anastomosis. Fifty-two patients (49%) had had one or more previous operations and dilatations, respectively. The immediate postoperative complication rate was 9 per cent. Ninety patients could be followed for one to eight years. The success rate was 93 per cent. Five patients had recurrent strictures. The failures were due to abscess formation, perineal hematoma, and excessive length of stricture.

Adolescent↗
PubMed1985

Combined radiation and chemotherapy for locally advanced transitional cell carcinoma of the urinary bladder.

A prospective study was performed on 22 patients with locally advanced transitional cell carcinoma of the urinary bladder to evaluate the toxicity and efficacy of an integrated treatment with cis-diamminedichloroplatinum (1.6 mg/kg body weight every 3 weeks for four cycles) and 60 G cobalt 60 or 18 MEV photons. Local and systemic toxicity caused by this treatment schedule was minor. Late sequelae consisted of contracted bladder in three patients. The rate of tumor-free bladders after a mean follow-up of 14 months was 17 of 22. Distant metastases occurred in three patients. Local recurrence of superficial tumor elsewhere in the bladder was observed in two patients. Six patients died 4 to 10 months after initiation of the integrated therapy, three of these without evidence of disease.

Aged↗
PubMed1985

[Combined radio-/chemotherapy of invasive bladder cancer].

In a prospective study, 19 patients with advanced transitional carcinoma of the bladder (stages T.3 and T.4) were treated by combined radiotherapy and chemotherapy. A total of 450 mg cis-platinum or 1.6 mg/kg body weight were given in four treatment periods with three-week intervals. At the same time, the total dose of 60 Gy was given to the tumour over two periods (telecobalt or high-energy photons). There were few systemic or toxic side effects. Recurrence-free survival during the next 36 months was 76%, which compares with a control group treated by irradiation only, who had a survival of 48%.

Aged↗
PubMed1984

Topical doxorubicin hydrochloride therapy for carcinoma in situ of the bladder: a followup.

A total of 10 patients with histologically proved carcinoma in situ of the bladder had remission of tumor after topical chemotherapy with doxorubicin hydrochloride for 24 months. Of the 10 patients 3 suffered new areas of carcinoma in situ 9 to 12 months after termination of intravesical chemotherapy. Furthermore, 1 of these 3 patients had a distal ureteral tumor. Fibrosis of the submucosal tissue was observed in every patient but a decrease in bladder capacity was observed in only 1 with prior radiotherapy.

Administration, Topical↗
PubMed1984

Early surgery in the management of pediatric blunt renal trauma.

Of 40 children with major blunt renal injuries managed surgically 30 (75 per cent) could be followed up to 13 years postoperatively (mean 4.5 years). Measurements of renal size on sequential excretory urograms demonstrated normal growth of the traumatized kidney in all but 1 child. No hypertrophy of the contralateral kidney was noted in any child. Kidney length correlated with renal plasma flow calculated by sequential scintiscans (r equals 0.77). Hypertension was noted in 3 patients. Split renal vein renin studies and angiography showed that hypertension was caused by renal artery stenosis in 1 patient. Although we cannot draw any firm conclusions with regard to the optimal management of major blunt renal injuries, we present precise data that are valuable in comparison to other series of patients managed conservatively or surgically.

Adolescent↗
PubMed1984

[Urethral prolapse. Case report].

The article reports on the case of a girl of 11 1/2 years of age who was referred to hospital with an urethral prolapse. The prolapsed urethral mucosa was excised and the wound closed by suturing.

Age Factors↗
PubMed1984

Biological behaviour and DNA cytophotometry of urothelial bladder carcinoma.

In this prospective study, primary urothelial bladder tumour specimens from 64 patients were investigated by means of DNA Feulgen cytophotometry. The patients were followed clinically for at least 7 years. The objective cytophotometric parameters correlated well with the histopathological grading and the cytochemical data were of considerable prognostic value. They were closely correlated with the stage of the tumour, 5- and 7-year survival rates and the probability of tumour recurrence. It is concluded that DNA cytophotometry can serve as a method for the standardisation of histological grading and can give more objective and more detailed prognostic information than conventional histopathology.

Adult↗
PubMed1984

Intravesical chemotherapy for carcinoma in situ of the urinary bladder: 5 years later.

46 patients with carcinoma in situ of the urinary bladder were treated with intracavitary chemotherapy. The mean follow-up was 33 months. Tumor remission, defined by negative cytology and no evidence of TIS or severe dysplasia on biopsy, was achieved in 78%. There were 6 deaths, but only 1 was due to bladder cancer. 22 patients were followed after the termination of the planned treatment protocol. Recurrence of carcinoma in situ or development of a superficial bladder cancer was observed in 10 (45%). Bladder biopsies performed at the end of treatment were of no predictive value with regard to tumor recurrence. Tumor remission was achieved in all patients who received repeated intracavitary chemotherapy.

Adult↗
PubMed1983

Reconstruction of abdominal wall and mons pubis in females with bladder exstrophy.

We report on 3 patients with bladder exstrophy who had considerable scar deformities of the lower abdomen after primary closure of the bladder and/or urinary diversion. The scar tissue was excised, and augmentation of the abdominal wall and mons veneris was achieved by the use of a pedicled, vascularized groin flap with integrated bone from the iliac crest. This procedure is recommended for patients with faulty closure of the pelvic ring and severe defect of the lower abdominal wall.

Abdominal Muscles↗
PubMed1983

Determination of carcinoembryonic antigen in tissue, serum and urine in patients with transitional cell carcinoma of the urinary bladder.

Carcinoembryonic antigen (CEA) is elevated in urine and/or serum of patients with transitional cell carcinoma (TCC) of the urinary bladder. A group of 26 patients with TCC of the urinary bladder were evaluated with regard to urine/serum CEA levels and CEA tissue content. CEA could be detected in normal, metaplastic and pre-neoplastic urothelium as well as tumor tissue. CEA was mainly localized on cell membranes, but with increasing tumor malignancy and infiltration a shift to cytoplasmatic localized CEA was noted. There was also a decrease in CEA content in the latter group. CEA urine levels were elevated above normal in more advanced tumor stages; however, the values varied greatly between individuals. All serum levels were within normal limits. No correlation could be established between urine/serum CEA levels and CEA tissue content.

Adult↗
PubMed1983

Investigation of ABH antigenicity of random mucosal biopsies and transitional cell carcinoma of the urinary bladder.

Blood group isoantigens can be demonstrated immunohistologically on normal bladder urothelium by means of the specific red cell adherence test. In preneoplastic and reactive changes of the urothelium as well as in carcinoma in situ, a loss of these antigens occurs. Blood group isoantigen content decreases with higher anaplasia of transitional cell carcinoma. Overt tumors without blood group isoantigens are associated with carcinoma in situ and severe dysplasia at a high percentage. These tumors are associated significantly more often with antigen-negative light-microscopically normal-appearing urothelium than antigen-positive ones do.

Blood Group Antigens↗
PubMed1983

[Ossified amyloidosis of the kidney pelvis].

A 52-year-old man was nephrectomized because of a tumor of the renal pelvis. Histologically the pelvic lesion proved to be a primary localized amyloidosis; pathogenesis, symptoms, diagnosis and therapy are briefly discussed.

Adult↗