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Biomedical subjects

G Jakse

Publications and source records attributed to G Jakse.

At least 181 records · Page 10Linked to original sources
PubMed1988

[Malacoplakia of the urinary tract].

Malacoplakia is a granulomatous disease that most frequently involves the genitourinary tract. Because of the great variability of symptoms and lack of typical radiologic findings, this disease is usually not considered preoperatively. Generally of benign nature in the lower urinary tract, it leads to destruction and loss of renal function when affecting ureter and kidney. Progression of the latter can only be prevented by surgical intervention. Malacoplakia of the lower urinary tract requires long-term treatment with intracellularly active antibiotics in combination with drugs enhancing phagocytosis.

Female↗
PubMed1988

[Inflammatory pseudotumor of the bladder].

A case report presents a 30-year-old lady with a pseudotumor of the bladder as large as a fist. The tumor originated from an inflammation around the rest of a suture following appendectomy with a latency of 7 years.

Adult↗
PubMed1988

[Iatrogenic tumor cell implantation in bladder cancer].

J82 monolayer cell cultures and 647 V multicellular tumor spheroids were incubated in Resectal, urine (pH 5.5; 7.5) and distilled water for 5-30 min. In the case of both monolayers and tumor spheroids inhibition of tumor cell growth was achieved by incubation in distilled water. Transurethral resection (TUR) of a primary superficial bladder cancer was performed in 133 patients (Ta, T1). In 60 of these patients selected biopsies of apparently normal bladder mucosa were taken at the same time. There was no significant difference in tumor recurrence between the groups with biopsy and without biopsy. However, all patients with dysplasia in the selected mucosal biopsies developed a tumor recurrence. Between 1969 and 1984 bladder wall perforation occurred in 12 patients during TUR of Ta, T1 bladder cancer. None of the patients who experienced bladder wall perforation developed extraperitoneal or intraperitoneal metastases. Although our clinical results suggest that iatrogenic tumor cell implantation during TUR of a bladder cancer is rather unlikely, this event could be prevented by the use of distilled water during and after TUR.

Adult↗
PubMed1987

[Intravesical immunotherapy of in situ carcinoma of the urinary bladder using Bacillus Calmette-Guerin (BCG)].

14 patients with primary, secondary or concurrent in situ carcinoma of the urinary bladder were treated intravesically with a solution of Bacillus Calmette-Guerin (BCG). Complete tumour remission was achieved in 9 patients. Local toxicity forced discontinuation of treatment in 3 patients. Tumour progression was not observed during treatment in any patient. Although there are still several unsolved questions concerning intravesical BCG treatment, it may already be considered to play an important role in organ-preserving bladder cancer therapy.

Administration, Intravesical↗
PubMed1987

[Systemic chemotherapy in advanced bladder cancer. New aspects].

Systemic chemotherapy has gained increasing importance in the treatment of advanced bladder cancer over the past few years. Implementation of cisplatin- and methotrexate-containing chemotherapy regimens results in a complete remission rate of over 20% in patients with metastatic bladder cancer. In view of these results prolongation of tumour-free survival is possible. A further indication for systemic chemotherapy is in cases of locally-advanced bladder cancer; in these patients chemotherapy can be given alone or in combination with irradiation. T3-tumours can be destroyed by integrated radiotherapy and chemotherapy in more than 70% of cases. The influence of this treatment modality on micrometastases is unclear.

Aged↗
PubMed1987

Ultrasound in patients with blunt renal trauma managed by surgery.

We investigated 24 patients with blunt renal trauma by excretory urography plus nephrotomography and ultrasound. The results of these investigations were correlated with the operative findings. The ultrasound diagnosis was correct in 16 of 18 patients with parenchymal injuries. Injuries to the renal pelvis, ureter and renal pedicle were suspected only in connection with excretory urography. Ultrasound provides an excellent inexpensive noninvasive diagnostic tool for the initial diagnostic study of patients with blunt renal trauma.

Adult↗
PubMed1987

Stage T1, grade 3 transitional cell carcinoma of the bladder: an unfavorable tumor?

Transurethral resection only was performed in 172 patients with initial stage Ta, T1 transitional cell carcinoma of the bladder. Additional treatment during the course of disease was given to 9 patients with carcinoma in situ and to 8 patients with tumor progression. The mean followup was 106 months. The 10-year survival rates were 95 per cent for patients with stage Ta, grade 1 disease, 89 per cent for stage Ta, grade 2, 84 per cent for stage Ta, grade 3, 78 per cent for stage T1, grade 2 and 50 per cent for stage T1, grade 3. The percentage of first tumor recurrence at the same site increased with tumor grade (stage T1, grade 3 was 74 per cent). The recurrence rate in stage T1, grade 3 tumors (4.08) differed significantly from the other groups of superficial tumors. The tumor progression rate for stage T1, grade 3 tumors (32.5 per cent) was significantly higher as well. The characteristics of stage T1, grade 3 tumors with and without progression were different in regard to multiplicity, recurrence rate, mean interval to recurrence and type of tumor invasion. Of the 13 patients who died of progressive neoplastic disease 11 presented initially with stage T1, grade 3 tumors. When these results are considered it is obvious that a patient with a stage T1, grade 3 tumor deserves additional therapy, such as chemotherapy, immunotherapy or phototherapy.

Aged↗
PubMed1987

Carcinoma in situ of the bladder extending into the seminal vesicles.

Involvement of the urethra or distal ureter in 30 to 50 per cent of the patients with carcinoma in situ of the bladder is well known. Carcinoma in situ of the bladder extending to the seminal vesicles rarely has been mentioned. We discuss 2 patients with extension of carcinoma in situ into the seminal vesicles and replacement of the normally present cylindroid mucosal lining. Carcinoma in situ of the ureter, bladder and prostatic ducts also was present in both patients.

Aged↗
PubMed1987

Multicellular bladder tumor spheroids in coculture with human endothelial cell monolayers.

Multicellular tumor spheroids (MCTS) are avascular spherical tumors grown systematically out of single cells in vitro. The coculture of MCTS of the human bladder carcinoma cell line J 82 with confluent human endothelial cell layers serves as a model to study cell-cell interactions as an important feature in hematogenous tumor spread. Basic information is obtained by phase contrast microscopy and histochemistry. More detailed information is given by the application of scanning and transmission electron microscopy. Immunohistochemistry helps to differentiate endothelial cells from tumor cells (factor VIII-related antigen). The application of this coculture model and of the various methods of evaluation enables us to study cell-to-cell contact phenomena systematically.

Carcinoma, Transitional Cell↗
PubMed1987

[Value of microhematuria, urine cytology, TPA and neopterin in the after care of patients with bladder tumors].

Tumor recurrences were observed 70 times in 715 cystoscopies performed in 253 patients. The sensitivity of microhematuria to detect a tumor recurrence was 61%, the specificity 84%. The sensitivity of microhematuria increased to 90% in Tis and T2 tumors. Urine cytology showed a specificity of 100% and a sensitivity of only 43%. The specificity and sensitivity of TPA was only 58% and 41%, respectively, the latter increased to 80% in Tis. 60 patients with proven tumor recurrence showed an increase of neopterin with higher tumor stage. In tumors of stage T2 and Tis serum neopterin was raised in 90% and urine neopterin in 75%. Based on these results cystoscopy, exfoliative urinary cytology and urine analysis are obligatory in the follow-up of patients with superficial bladder cancer. Because of the low specificity (29-41%) TPA and neopterin are not suitable for follow-up.

Biopterins↗
PubMed1987

Hyperfractionated, accelerated radiotherapy and concurrent chemotherapy in locally advanced bladder cancer.

A prospective study was performed on 11 patients with locally advanced transitional cell carcinoma of the bladder to evaluate the toxicity of an integrated treatment with cis-platinum (70 mg/m2 body surface), doxorubicin (10 mg/m2 body surface) and 8 meV photons. Local and systemic toxicity caused by this treatment schedule was minor. Late sequelae consisted of reduced bladder capacity in 2 patients and proctitis in 1 patient. Complete clinical clearance of the local tumor could be achieved in 9 of 11 patients after a mean follow-up of 8.1 months.

Aged↗
PubMed1987

[Topical BCG therapy of in situ cancer of the urinary bladder].

Ten patients with primary, secondary and concurrent Tis were treated by intravesically instilled BCG-solution. A complete tumor remission could be obtained in 6 patients. Local toxicity was the reason for discontinuing the treatment in 2 patients. One patient developed a granulomatous prostatitis during the treatment. Although significant side effects did occur we think that topical BCG therapy is an effective treatment modality in Tis of the urinary bladder.

Administration, Intravesical↗
PubMed1986

[Bladder cancer as an incidental finding].

Transitional cell carcinoma of the urinary bladder was found in 54 patients as an incidental finding. These patients are compared with 618 patients with symptomatic tumours as regards tumour type, grade and stage. The mean age is lower, there are more women and less tumours of high malignancy in the asymptomatic group than in the symptomatic. The main clinical sign in the symptomatic patient is gross haematuria. With increasing tumour stage and grade there are significantly more patients with dysuria and pollacisuria. Comprehensive urological examination of patients with dysuria or microhaematuria is a necessity. Sonography should be used as a valuable tool in the early detection of bladder tumours.

Adenocarcinoma↗
PubMed1986

Urothelial dysplasia and carcinoma in situ of the bladder.

Urothelial cells were pepsin-extracted from paraffin-embedded specimens taken from human nontumorous bladder mucosa, dysplasia, and carcinoma in situ. After Feulgen staining for DNA, nuclei were measured with an integrating microdensitometer. The measurements show that normal urothelium consists mostly of diploid nuclei. Dysplasia means that there is a predominance of tetraploid DNA values, whereas carcinoma in situ is characterized by a high percentage of aneuploid cells. In both dysplasia and carcinoma in situ there is a considerable percentage of diploid nuclei. Thus, DNA cytophotometry can be used for standardization of preneoplastic and early stages of tumor development in bladder cancer.

Carcinoma in Situ↗