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Biomedical subjects

G Huber

Publications and source records attributed to G Huber.

At least 181 records · Page 10Linked to original sources
PubMed1982

[Examinations by psychological tests in basic stages and pure residual syndromes of schizophrenic diseases (author's transl)].

Three groups of schizophrenic diseases which cannot be differentiated with regard to psychopathological cross-section syndromes were investigated by psychological tests: one group (22 cases) of reversible postpsychotic basic stages and two groups of pure residual syndromes with an average duration of disease of 9.3 years (20 cases) and 17.5 years (21 cases). All three groups revealed findings deviating significantly from the norm. The pathological values were most marked in the performance scale of HAWIE (Hamburg-WAIS), which in all groups showed a significant lowering of performance compared with verbal scale (which corresponds approximately to the premorbid intelligence level), in "KVT" and in measures of sensory-motor reaction time by "Wiener Reaktionsgerät", less in "Benton test" and in examination with "Schreibdruckwaage". Reversible postpsychotic asthenic basic stages could not be significantly differentiated in psychological tests from pure residual syndromes which were comparable with regard to sex and age at the onset of the disease and--in the pure residues group of 1980--with regard to age and school success. The decrease of performance in the reaction test, in the concentration test of Abels, and in the averbal part of HAWIE correlated with symptoms and factors which were found with the help of "Frankfurter Beschwerdefragebogen" in the same patients. This positive correlation was more distinct in the reversible postpsychotic basic stages than in pure residues. The findings support the global hypothesis that the deficiencies of schizophrenic stages with a component of reversible or irreversible pure potential reduction are based on disturbances of perception and interpretation of information. Also that there are no fundamental differences between cerebro-organic or psychosyndromes of schizophrenic diseases determined by the dynamic and cognitive disorders of pure deficiency.

Adult↗
PubMed1982

Computerized tomography studies on schizophrenic diseases.

Earlier clinical pneumoencephalographic studies showed a subgroup of schizophrenics that have small and dysplastic cerebral ventricles as well as a subgroup with a "pure defect", i.e., a slight internal brain atrophy. In echoencephalograms of pure and mixed residual schizophrenic syndrome patients, a significantly higher average transverse diameter of the third ventricle was demonstrated compared to that in patients with complete remissions. Correlations cannot be expected between certain groups of disease, e.g., epilepsy, multiple sclerosis, or schizophrenia on the whole, and pneumoencephalographic (PEG) and CT findings. Only schizophrenics with distinct signs of pure defect that had persisted for at least 3 years revealed deviations from normal by CT and PEG, but those with irreversible fixed deformations of personality structure ("Strukturverformungen" [9,10]) did not. In patients who were 50 years of age or less with psychic reactive and psychopathic personality disorders, CT showed an average third ventricle diameter of 4.2 mm (range 2-6 mm). Of 117 schizophrenics (average age 35.5 years), only 28% revealed pathological CT changes. However, of 36 schizophrenics with pure residual syndromes 69% showed pathological CT findings that always concerned the third ventricle, rarely the lateral ventricles, and in no case the cortex. The average transverse diameter of the third ventricle in this subgroup with pure defect was 7.6 mm, as compared to 4.6 mm in the subgroup of schizophrenics with complete remission. There was no increase in size with increasing years until the 50th year in schizophrenics, as well as in the control group of variations of psychic being (neuroses and psychopathic personality disorders).

Adolescent↗
PubMed1982

[Catecholamine excretion during physical exercise and mental performance].

The basal and exercise-induced heart rates, lactate levels, and the adrenaline and noradrenaline excretions in the urine were measured during different types of physical exercise and mental performance: during moderate physical exercise (Ia, n = 12), submaximal physical exercise (Ib, n = 24), during moderate mental performance (motorway driving, IIa and IIb, n = 25), higher-grade mental performance (driving car-simulator, III, n = 14), and during submaximal mental performance (car racing, IV, n = 48). The moderate physical exercise and moderate mental performance could not be differentiated from one another, or from the higher-grade mental performance using the above-mentioned parameters. Both the submaximal physical exercise and mental performance resulted in a comparable lactate acidosis, heart rate increase, and noradrenaline excretion; the excretion of adrenaline is, however, 3 times higher after submaximal mental performance, than after submaximal physical exercise. The ratio of adrenaline to noradrenaline excretion changed from approximately 1:4 (during physical exercise and moderate mental performance) to approximately 1:2 during submaximal mental performance. The excretion of adrenaline and the ratio of adrenaline to noradrenaline excretion can therefore be used to differentiate between higher-grade mental performance and physical exercise. These parameters can be easily measured without discomfort to the subjects.

Acidosis↗
PubMed1982

[Measurements of the intracranial CSF spaces by computer tomography (author's transl)].

A method for quantifying the CSF compartments in cranial computer tomograms is described. The method is based on an analysis of the histogram curve, the proportion of area and thickness of the liquor spaces being related to the total area below the curve. In order to isolate the skull contents, a CT masking technique is used. The practicability and usefulness of the method in clinical practice was tested in 59 normal patients and in eleven patients with rapidly progressing brain atrophy.

Adolescent↗
PubMed1982

The dilemma of denial in the assessment of competency to refuse treatment.

To illustrate the dilemma in evaluating and treating patients who deny their illness, the authors present the case of a woman with paranoia who denied she was ill and refused medication. They focus specifically on the issue of whether a patient who denies his or her illness is truly legally competent to refuse or consent to treatment. They conclude that the assessment of such competency requires a consideration of the accuracy of the patient's "appreciation of the nature of his or her situation" and that safeguards have to be built into a system for evaluating competency along these lines to prevent abuse.

Adult↗
PubMed1981

Aldosterone-induced proteins in toad urinary bladders. Identification and characterization using two-dimensional polyacrylamide gel electrophoresis.

Aldosterone-stimulated Na+ transport is mediated by new protein synthesis, but the identification of specific aldosterone-induced proteins (AIPs) has proven difficult and the cellular function of such proteins is unknown. Using high resolution two-dimensional polyacrylamide gel electrophoresis and autoradiography we have identified AIPs of similar isoelectric points (5.8 to 6.4) and molecular weights (70,000 to 80,000) in membrane-rich and cytosolic subcellular fractions of epithelial cells derived from single toad urinary bladders. The ability of actinomycin D to inhibit both AIP synthesis and aldosterone-induced Na+ transport is consistent with a role for these proteins in the natriferic action of aldosterone. In addition, since non-natriferic concentrations of cortisol did not induce similar proteins, AIP synthesis appears to be mineralocorticoid-specific. The relationship of AIP synthesis to Na+ transport was also studied. Since amiloride, which blocks Na+ transport in high resistance epithelia, did not affect the synthesis of these proteins, Na+ transport is not required for their synthesis. In addition, similar proteins were not induced when Na+ transport was stimulated by antidiuretic hormone and theophylline. Consequently, AIP synthesis is not merely a nonspecific consequence of the cellular metabolic changes associated with Na+ transport.

Aldosterone↗
PubMed1981

[Room air quality and ventilation].

In a test chamber of 30 m3 the air pollutants caused by man were measured. Variables were: number of persons and their activities and the rate of the air change. During test sessions of two hours the temperature, the relative humidity, the carbon dioxide and the intensity of odors were measured. There was a significant correlation between the odor intensities and the concentrations of carbon dioxide-independent of the number of persons and the air change rate. At air change rates of 12-15 m3 per person and per hour, the carbon dioxide concentration was not higher than 0.15% and the odor intensity was evaluated only as a slight annoyance. Further experiments were performed with physical activity and smoking.

Air↗
PubMed1981

Plasma catecholamines in trained and untrained volunteers during graduated exercise.

Ten untrained subjects and nine trained cyclists were examined during graduated ergometric exercise in the supine position. The levels of epinephrine and norepinephrine in the blood as well as the heart rate and oxygen intake were determined. At submaximum levels, epinephrine, norepinephrine, lactate, and the heart rate are lower in tthe trained than in the untrained subjects; the relative oxygen intake shows no significant difference. The ergometric work capacity is approximately 30% higher in the trained cyclists. During maximum ergometric exercise, the plasma catecholamines, lactate, and the heart rate show no differences between the two groups; the oxygen intake is approximately 30% higher in the trained than in the untrained subjects. A direct relationship exists between catecholamine levels and lactate; however, this relationship becomes less exact during higher exercise intensities: In reference to the same catecholamine concentration, the lactate levels as well as the submaximum heart rates are higher in the trained than in the untrained subjects, the cause of which could be an increased beta-adrenoceptor sensitivity in the trained subjects.

Adult↗