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Biomedical subjects

G Huber

Publications and source records attributed to G Huber.

At least 199 records · Page 11Linked to original sources
PubMed1980

Intracranial carotid anastomosis and partial aplasia of an internal carotid artery.

A rare arterial anastomosis between the right and left internal carotid arteries at the base at the skull, with aplasia of the cervical part of the left internal carotid artery is reported. The case is unusual because, in addition to the vascular anomaly of the carotid artery, there is an aneurysm of the anterior communicating artery and bilateral renal cysts. The condition is a complex malformation syndrome caused by defective regression of the third branchial artery. Because of the characteristic angiographic aspects such a case should be called transverse carotid anastomosis.

Adult↗
PubMed1980

Longitudinal studies of schizophrenic patients.

A sample of 502 schizophrenic patients, who had been admitted to the University Psychiatric Clinic between 1945 and 1959, was systematically followed up between 1967 and 1973. The same well-defined diagnostic criteria were used throughout the study. At the time of the last followup, the average duration of illness was 22.4 years. Twenty-two percent of the patients showed complete psychopathological remissions, 43% had noncharacteristic types of remission, and 35 percent suffered from characteristic schizophrenic deficiency syndromes. Psychopathological outcome in the patients studied was assessed in relationship to such factors as duration of illness, social remission, family history of schizophrenia, primary personality, educational level, social class, age at onset, and presence of precipitating factors. It is concluded that prognostic predictions are possible only when several factors with a similar influence on long-term outcome occur in combination and when factors with a contrary prognostic influence are absent. Even under these circumstances, the individual course is by no means certain. The hypothesis that presenting symptomatology can be used to differentiate between true schizophrenias and schizophreniform psychoses is not supported.

Adult↗
PubMed1980

[Modification of long-term schizophrenia by somato-therapeutic measures].

Controlled studies have revealed that neuroleptic treatment alone has a significant effect in schizophrenic patients and that with parenteral treatment with depot neuroleptics the relapse rate after 1 and 2 years is significantly lower than with oral neuroleptic medications. About 20% of schizophrenic patients do not have relapses even without treatment. The effectiveness of neuroleptic long-term medication with regard to the prevention of relapses was proved by discontinuation trials for a period of up to 3 years. Up to now, however, there is no proof that drug therapy influences the long-term prognosis beyond the 3 years. The results of the Bonn schizophrenia study show the extraordinary variability of the courses and outcomes. Although some anamnestic and clinical prognostically favourable or unfavourable factors could be found, a reliable individual prognosis at the onset of the disease is not possible. Initially phasic courses with complete remission of the early psychotic features can later nevertheless lead to residual syndromes; on the other hand, chronic persistent psychoses can show a permanent remission leaving only slightly, non-specific residual states even as late at the 2nd to the 4th decade of the disease independent of the therapy. Some findings of the Bonn study, indicating a favourable influence of psychical treatments on the long-term course are described. They include the so-called catastrophic schizophrenia which at a rate of 4% occurs less frequently than in the past, the significantly poorer long-term prognosis of those patients who had not been treated in the beginning of the disease (taking into account subgroups with peracute, acute and subacute onsets on the initial psychotic manifestations), the significantly less favourable long-term prognosis of patients whose disease began prior to the era of psychopharmacological drugs, and the significantly more frequent occurrence of complete remissions of patients of the subgroups with peracute and acute onsets of the psychosis who had started treatment within 1 year after the onset of the disease (including the prodromal stage). Early diagnosis and treatment of the prodromal symptoms can probably improve the chance of a complete remission. The finding of a higher rate of patients with mixed residual states at the expense of the typical schizophrenic defect psychoses within the partial subgroup of the specific residual state with long-term neurolepsy could suggest that long-term medications is responsible for the 'partially pharmacogenic change in symptomatology' of schizophrenia in as far as it causes or favours a shift from the typical syndromes to the mixed residual states mainly bought about by a potential reduction in symptoms.

Antipsychotic Agents↗
PubMed1980

Effects of acetaldehyde upon mechanical properties of isolated rat papillary muscle.

The acute effects of acetaldehyde upon the performance of isolated rat papillary muscle were studied. At high concentrations (50 and 100 mg/100 ml), acetaldehyde demonstrated a negative inotropic effect and abbreviated relaxation time. Pretreatment with either propranolol or reserpine unmasked a direct negative inotropic effect of acetaldehyde at concentrations as low as 5 mg/100 ml. The shortening of relaxation was also blocked by propranolol and reserpine. These findings are compatible with both a direct myocardial depressant effect and an indirect beta-stimulatory effect of acetaldehyde. In the range of concentrations encountered clinically, however, acetaldehyde is not likely to have a significant acute effect upon cardiac muscle performance.

Acetaldehyde↗
PubMed1980

[Optimum utilization of the ventilation system to reduce airborne bacteria in operating rooms].

In 4 operating theatres with 4 different air-conditioning equipments, the number of bacteria per m3 circulating air in the neighbourhood of the open wound has been investigated. The testing has been performed on comparable aseptic operations. The worst results were obtained in 2 conventional theatres, equipped with a modern-up-to-date air-conditioning. The number of bacteria was ranging between 230 and 270 per m3. A much better results was obtained in a theatre, equipped with a so-called germ-stop-wall, dividing the theatre into 2 sections, separating the surgical team and the open wound completely from the anaesthesist and other staff. With this arrangement, 45 germs per m3 were found. The best result with no bacteria at all is present in a vertical flow-enclosure with an exchange rate of 32 per hour. According to our 10-year experience, for aseptic surgery sterile air techniques should be adopted to improve asepsis and to decrease the risk of postoperative infection.

Air Conditioning↗
PubMed1980

[The value of brain scanning in cerebro-vascular disease by CT (author's transl)].

Brain scanning by scintigraphy and CT studies of the brain are complementary methods. The precise demonstration of the anatomy and the pathology of the brain by CT is supplemented by brain scintigraphy due to the latter's value to assess the hemodynamic properties of a lesion and thus provide important clues to its site and sometimes even its histology. This is especially true in vascular brain disease thus either dispensing the need for an invasive procedure such as angiography or providing information for a specific approach.

Brain Neoplasms↗
PubMed1980

[Biochemical changes after endurance exercise in children and juveniles (author's transl)].

In 6 groups of children and juveniles (aged 8-16 ys) the exercise induced changes (cross country skiing of different durations) in various blood-parameters (Na, K, Ca, Mg, glucose, lactic acid, free fatty acids, glycerol, triglycerides, cholesterol, urea, CK-activity) are shown in contrast to changes in adults. It was found, that there are differences in the matabolic behaviour of the groups examined; previous data in adults must be applied, with restrictions, to results found in children or juveniles. Single parameters are not sufficient to obtain informations about influences of intensive endurance training in juveniles. Remarkable changes after long-lasting exercise must be expected in the blood values of K, Mg, urea, insulin and STH.

Adolescent↗
PubMed1979

Effects of tetracyclines on aldosterone- and insulin-mediated Na+ transport in the toad urinary bladder.

The effect of oxytetracycline and demethylchlortetracycline on aldosterone- and insulin-mediated Na+ transport (short-circuit current) were examined in toad urinary bladders mounted in modified Ussing chambers. Oxytetracycline had little or no effect on either basal or aldosterone-mediated Na+ transport. In contrast, demethylchlortetracycline markedly inhibited both basal and aldosterone-mediated Na+ transport. Furthermore, demethylchlortetracycline inhibited the aldosterone response significantly out of proportion to its effects on basal Na+ transport. Neither of the drugs had an effect on insulin-mediated Na+ transport. Consequently, the natriuresis observed in certain patients treated with demethylchlortetracyline may be related to drug-induced renal resistance to the effects of aldosterone.

Aldosterone↗
PubMed1979

Hydrocephalus after subarachnoid bleeding. A correlation of clinical findings, the results of radioisotope Cisternography and computer-assisted tomography.

Out of a group of patients suffering from a spontaneous subarachnoid hemorrhage 27 patients were checked by computer-assisted tomography (CAT), 23 patients by radioisotope cisternography, and 21 patients by both diagnostic procedures. The results were correlated with the clinical observations. The flow of the CSF was normal in 7 patients (30.43%), and pathological in 16 patients (69.56%). Of the 27 patients checked by CAT, 23 (85.18%) showed a ventricular dilatation, which in 17 patients (62.96%) was not connected with a corresponding increase of the cisterns of the convexity. The clinical symptoms of hydrocephalus, the degree of impairment of the circulation of the CSF determined by radioisotope cisternography and the ventricular diameter as determined by CAT correlated well.

Adolescent↗