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Biomedical subjects

G Hartmann

Publications and source records attributed to G Hartmann.

At least 127 records · Page 7Linked to original sources
PubMed1986

Correlation between monoamine content and other parameters of cerebrospinal fluid in aneurysmal subarachnoid haemorrhage: a case report.

The monoamine content and other parameters of cerebrospinal fluid (CSF) were studied in aneurysmal subarachnoid haemorrhage (ASH). The blood content of CSF was determined by the protein concentration and cell count, while the haemostatic status of the patient was characterized by the prothrombin level of blood. The serotonin content of CSF was elevated at the beginning of ASH (high protein content and fresh blood cells in CSF, and low level of prothrombin in blood). Later the level of serotonin and protein of CSF decreased, while the prothrombin level of blood increased. During rebleeding on the 20th day after admission, the CSF serotonin and protein content increased again, while the prothrombin level of blood was decreased. The dopamine and noradrenaline levels of CSF markedly decreased on the 11th day after ASH, but in the following days these parameters returned to the control level. The findings suggested that the serotonin content of CSF originated mainly from extravasated blood. The decreased level of dopamine and noradrenaline 11 days after ASH might be connected with increased blood viscosity, decreased peripheral blood pressure or other changes.

Cerebrospinal Fluid Proteins↗
PubMed1985

[Acute hypercalcemia syndrome in sarcoidosis].

In a 26-year-old patient admitted to the emergency ward with acute abdomen, all the symptoms--nausea, vomiting, indeterminate abdominal pain, constipation, renal failure, polyuria and polydipsia--could be explained by calcium intoxication syndrome. Investigation revealed generalized sarcoidosis. Under medical treatment with prednisone all the pathologic findings rapidly regressed. The pathogenesis of hypercalcemia in sarcoidosis, and particularly the disorder of vitamin D metabolism with raised levels of 1,25-dihydroxycholecalciferol, are discussed.

Abdomen, Acute↗
PubMed1985

The influence of NaCl supplementation on the postnatal development of urinary excretion of noradrenaline, dopamine, and serotonin in premature infants.

The present study was designed to investigate the role of noradrenaline (NA), dopamine (DA), and serotonin (5-HT) in the adaptation of premature infants to alterations of sodium balance. Urinary excretion of NA, DA, and 5-HT was measured spectrofluorimetrically in a group of low birth weight premature infants with (group S) and without (group NS) NaCl supplementation. Group NS consisted of 10 infants with a birth weight of 1200-1750 g (mean, 1493 g) and gestational age of 28-31 wk (mean, 30.1 wk). Group S included 10 infants with mean birth weight of 1414 g (range, 1150-1600 g) and mean gestational age of 30.5 wk (range, 27-32 wk). Measurements were made on the 7th day and weekly thereafter until the 5th wk of life. NaCl supplementation was given in a dose of 3-5 and 1.5-2.5 mEq/kg/day for 8-21 and 22-35 days, respectively. In group NS, mean urinary excretion of NA and DA increased from 8.6 +/- 1.5 and 15.8 +/- 2.4 micrograms/day to maximum values of 21.4 +/- 5.5 (p less than 0.05) and 33.4 +/- 6.0 micrograms/day (p less than 0.01) in weeks 2-3, respectively. 5-HT excretion averaged about 60 micrograms/day and showed no consistent change during the course of the study. NaCl supplementation prevented the rise of NA and DA excretion above the initial baseline values. The postnatal course of 5-HT excretion, however, remained unaffected by NaCl supplementation. Urinary excretion of NA in weeks 2-3 (p less than 0.05) and DA in weeks 2-4 (p less than 0.05) were significantly lower in group NS.

Dopamine↗
PubMed1985

[Causes of death in hemophilia patients in East Germany].

By means of the Central Card Index of Haemophilia, a working material of the Section of Haemophilia in the Society of Haematology and Blood Transfusion of the GDR, 52 patients with heriditary haemorrhagic diatheses could be registered. These persons had died between 1962 and 1984. The average age of death amounted to 33.8 years. With 23 cases intracranial bleedings were the dominating cause of death in all haemophiliacs. From this fact the absolute necessity arises to initiate a substitutive therapy with a sufficiently high dosage, if there is an assumption of a craniocerebral trauma and, in addition, to treat hypertension in such a way that normotonic values are achieved. Even retrospectively no signs of an acquired immunodeficiency syndrome could be found in any of the patients. As haemophilic bleedings apparently represented the life limiting factors in the majority of the deceased, the importance of an early adequate substitutive therapy is stressed, the principles of which should be known to all general practioners.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Relations with cancer patients].

A patient suffering from cancer expects to be cured by surgery, irradiation or chemotherapy. Despite of great progress in treating malignant tumours a great deal of these patients come to death due to their disease. This fact is known to the patients. Therefore, their personal attitude is often characterised by anxiety, hopelessness and impairement of their ability to communicate. Surgeons should know this and pay more attention to the special psychic situation of their tumour patients.

Adaptation, Psychological↗
PubMed1984

[Goodpasture syndrome and (idiopathic) immune complex glomerulonephritis with pulmonary hemorrhage: 2 different syndromes?].

While Goodpasture syndrome was previously defined purely clinically by the combination of pneumorrhagia and glomerulonephritis, today the following immunologic criteria must also be satisfied: evidence, provided by immunofluorescent investigation of the kidneys and lungs, of antibasement membrane antibodies in the serum and linear deposits of immunoglobulins, due to direct apposition of antibasement membrane antibodies. Cases where the lesions are caused by immune complexes should no longer be designated as Goodpasture syndrome. In the light of one of our own cases of immune complex glomerulonephritis with pneumorrhagia, the question is raised whether this subdivision by means of immunologic investigations is meaningful for the clinician.

Adult↗
PubMed1984

Noradrenaline content of cerebrospinal fluid in preterm and term infants recovering from perinatal asphyxia.

Noradrenaline content was measured in the cerebrospinal fluid of 17 full-term and 16 premature newborns with or without perinatal asphyxia. Upon the effect of asphyxia the noradrenaline content of cerebrospinal fluid exhibited a more than three-fold increase (from 2.61 +/- 1.45 microgram/l to 10.86 +/- 4.02 micrograms/l) in mature newborns, but it decreased to about half of the control value in premature babies (from 2.39 +/- 0.72 microgram/l to 1.25 +/- 0.70 microgram/l). The observations emphasize the role of central noradrenergic structures in the organization of asphyxia-induced stress-response and in the regulation of adaptation to extrauterine life.

Asphyxia Neonatorum↗
PubMed1983

[Does HDL-cholesterol determination facilitate the assessment of risk in coronary patients?].

Serum lipids (cholesterol, triglycerides, HDL-cholesterol) were analyzed in 153 patients with proven coronary heart disease (CHD) with the target to characterize the risk potential of HDL-cholesterol. It turns out, that the specificity of HDL-C is low (too many unexpected high values in CHD). Consequently this parameter is of little use in evaluating the individual risk for CHD.

Aged↗
PubMed1983

Effect of stress and cholinergic stimulation on ACTH release in alpha-methyl-dopa pretreated rats.

Pituitary-adrenocortical function and the changes of hypothalamic catecholamine content were studied following alpha-methyl-dopa treatment in rats. After three-day administration of alpha-methyl-dopa the plasma corticosterone concentration increased significantly and at the same time ether stress failed to elicit a pituitary-adrenocortical response. Moreover, the alpha-methyl-dopa pretreatment prevented the facilitatory effect of physostigmine on pituitary-adrenocortical activation. As the result of alpha-methyl-dopa treatment the norepinephrine content decreased significantly and the amount of compounds measured as dopamine (dopamine, alpha-methyl-dopamine and alpha-methyl-dopa) increased in the hypothalamus. It is concluded that the impaired metabolism of catecholamines may inhibit the pituitary-adrenocortical activation to stimulation, and that not only norepinephrine and dopamine, but other phenylalanine derivatives and alpha-methyl-dopa may also influence the responsiveness of pituitary-adrenocortical function.

Adrenocorticotropic Hormone↗
PubMed1982

[Early diagnosis of stomach cancer: reality or illusion?].

Cancer of the stomach is, in Switzerland, the fourth most common malignant tumor in both sexes. The five year survival rate is between 10 and 20% in Europe; where the cancer is diagnosed early, however, the patients have a survival rate of 85-95%. Of the 305 cases diagnosed in the last 5 years, 51.5% were operatively curable. In 29.5% of the cases palliative surgery was possible and 19% were inoperable. The rate of early cancer is 12% and thereby constitutes the largest portion of the total five year survival rate. Improvement of prognosis is only realizable through early detection, but even today this prospect is largely illusory. Practicable ways of obtaining optimum results are demonstrated.

Aged↗
PubMed1982

Recursive features of circular receptive fields.

The distribution of excitability in retinal receptive fields may be well approximated by functions with recursive features. Physiological data do not exclude an implementation of recursive structures in the visual system. It is the most remarkable advantage of a recursive visual system, that cortical receptive fields tuned to different spatial frequencies will have an identical neuronal circuitry. Structural consequences for retina, LGN and visual cortex are discussed.

Animals↗