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Biomedical subjects

G Dutau

Publications and source records attributed to G Dutau.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Somatotropin secretion during sleep in 60 cases of growth retardation in children].

A study of nocturnal somatotropic secretion with sleep polygraphic recording was performed in 60 children, aged 1 to 18 years and presenting with growth retardation greater than or equal to -2SD. GH secretion was analysed according to the peak value, the number of peaks greater than 5 ng/ml and the integrated concentration (surface under the curve divided by the duration of the test). The children were studied in four groups according to the responses to pharmacologic stimulation tests: a normal group (n = 7), a group with complete somatotropic deficiency (n = 4), a group with partial somatotropic deficiency (n = 39) and a group with dissociated responses (n = 12). Results are concordant between sleep secretion and pharmacologic tests in the first two groups. On the contrary, in the two last, the study of the sleep secretion allows to differentiate children with hyposecretion ("true partial deficiencies") from children with normal secretion ("false partial deficiencies") or abnormal responders). In other respects, correlations between LH maximum peak and stages of sleep are analysed. The maximum peak was observed in only 33.9% of cases during stage IV, 21.5% of cases during stages I, II, III, in 19.6% of cases during wakefulness and in 25% of cases during paradoxical stage. The maximum peak was observed in only 48% of cases during the first cycle of sleep and in 52% of cases during the other cycles. These results show that the correlation between maximum peak, stage IV and first cycle of sleep is not absolute.

Adolescent↗
PubMed1984

[Results of treatment with growth hormone. Apropos of 31 cases of pituitary insufficiency].

The results of treatment with human growth hormone in 31 children with hypopituitarism are reported. 19 boys and 12 girls were treated for several years, six years in three instances. Pituitary insufficiency was idiopathic in 23 cases (isolated in 11 and associated with other deficiencies in 12) and secondary in 8 cases. The mean statural gain during the first year of treatment was 6.3 +/- 2.2 cm with a mean dosage of 9.3 +/- 4 mg/kg/year. The parameters which have the most bearing on statural gain during the first year are: dosage (p less than 0.001) which must be at least equal to 8 mg/kg/year, bone age and chronologic age. In subsequent years statural gain is less significant and seems to be dependent upon the same parameters.

Adolescent↗
PubMed1984

[The surface of epiphyses of the knee: index of the duration of neonatal hypothyroidism].

The surfaces of the epiphyses of the knees were calculated in 34 neonates with hypothyroidism detected with a systematic screening and in 32 normal neonates. In the group of neonates with hypothyroidism, the surface of the lower femoral point was 12.7 +/- 0.9 mm2 and that of the upper tibial point 1.8 +/- 0.9 mm2. There was a significant difference (P less than 0.01) for both epiphyses between children of the 2 groups. The use of mathematical formula excluding non specific factors showed significant correlation between the corrected values for lower femoral points, and T4 and T3 plasma levels. These corrected values were higher in neonates with thyroid ectopia than in neonates with thyroid aplasia. There was also a significant correlation between the corrected values for lower femoral points and the IQ at 6 months and 2 years. Thus, the calculation of the surface of the epiphyses of the knee may be considered as a criterion of duration and severity o hypothyroidism and may be an index for the determination of the ante- or post-natal onset of the disease.

Bone Development↗
PubMed1984

[Trisomy 12(pter----q12) and monosomy 21(pter----q21). A propos of a case].

The authors report an observation of a child with both trisomy 12(pter----q12) and monosomy 21(pter----q21). It is thus possible to detect the clinical signs which can be attributed to trisomy 12p and to monosomy 21ql respectively. The authors point out the originality of the maternal translocation which differs from the translocations affecting these two chromosomes previously described in the literature. Finally, the rarity of the type of adjacent-2 segregation is shown, and discussed according to the literature already published.

Chromosome Aberrations↗
PubMed1983

[Unusual course of alpha-fetoprotein levels in a case of spina bifida detected by prenatal diagnosis].

The authors report the observation of a case of spina bifida detected at the 18th week from a systematic prenatal screening at the C.H.R. in Toulouse, from the assay of alpha foeto-protein on filter paper. The course of total alpha foeto-protein was particularly unique: high levels found at the 18th week with a progressive decrease in concentration until totally normal level was reached during the 28th week. Ecography confirmed the diagnosis of spina bifida. Total alpha foeto-protein concentration was also found at normal level during the 28th week in serum and in amniotic fluid. Therapeutic abortion confirmed the diagnosis of spina bifida. The authors discuss this unique course of alpha foeto-protein levels from the 18th week of development to the 28th week, made possible by this rather valuable observation.

Adult↗
PubMed1983

[Hot pseudonodule disclosing a thyroid cancer in a child].

The authors report on a 11 1/2 year-old boy presenting with a palpable thyroid nodule. 99mTc and 131I scintigrams showed hyperfixation of this nodule (hot nodule). Surgical removal showed follicular-papillary carcinoma. These thyroid carcinomas revealed as hot nodules, seem to be exceptional.

Adenocarcinoma↗
PubMed1983

[Thyroid ectopia, a cause of error in neonatal screening for hypothyroidism].

The authors report the case of a boy presenting with hypothyroidism due to ectopic thyroid, diagnosed at age 3 years. The results of neonatal screening for hypothyroidism (T4 + TSH) had been normal. A large ectopic thyroid might have been responsible for normal levels of thyroid hormone at birth.

Child, Preschool↗
PubMed1982

[The succession of precocious puberty and Stein-Leventhal syndrome].

The authors relate the observation of a girl with precocious puberty diagnosed at 4 years, treated for 7 years with medroxyprogesterone and who presents now a Stein-Leventhal syndrome. They emphasize the unique character of this association and discuss the different pathogenetic hypotheses: hypothalamo-pituitary disorder, effect of medroxyprogesterone acetate, hyperinsulinism, casual association.

Androstenedione↗
PubMed1981

HLA-DR7 in children with idiopathic nephrotic syndrome. Correlation with atopy.

Idiopathic nephrotic syndrome (INS) of childhood is likely to be underlain by an immunopathological mechanism; we investigated the presence of immunogenetic HLA markers in this disease. Fifty-four unrelated INS-affected children, among them 20 with an allergic status, were studied for 33 HLA-A,B and 6 HLA-DR antigens. The results were compared to those obtained in 49 children with glomerulonephritis, 28 children with atopy but without nephropathy, and 91 healthy blood donors. The HLA-A and B antigen frequencies were not significantly different from normal frequencies. The incidence of HLA-DR7 was significantly increased in INS-affected patients as compared to the other groups (66.7% in patients vs 31.1% in healthy controls; corrected P value less than 0.001; relative risk = 4.4), and more so in those with atopy than in those without atopy (90% vs 46%; P = 0.002). The frequency of this antigen is not increased in atopic non-nephrotic children. No relationship between HLA-DR7, clinical outcome and steroid-responsiveness was found. We suggest that the pathogenesis of INS could be influenced by an HLA-linked immune response gene, especially in its atopy associated form.

Child↗
PubMed1981

[Antenatal screening for neural tube defect by measuring alphafetoprotein in dried blood eluates (author's transl)].

Alphafetoprotein (AFP) was measured during pregnancy in dried blood eluates. Normal values (50th percentile) were established from 5,000 women throughout their pregnancies. AFP levels progressively increase from the 6th week (3.0 ng/ml whole blood) to the 32 week (124.0), then decrease slowly (70.1). Correlations between serum AFP and AFP from eluates is highly significant (p less than 0.001). Preservation of blood samples on blotting paper is good. An experimental screening of more than 1,500 pregnant women detected one case of anencephaly.

Female↗