Search PubMed⌕ Search

Biomedical subjects

G Dutau

Publications and source records attributed to G Dutau.

At least 73 records · Page 4Linked to original sources
PubMed1990

[Continuous subcutaneous infusion of beta 2-agonists in infantile asthma].

Five infants aged 7 to 17 months were treated for asthma with a continuous subcutaneous infusion of a beta 2-agonist for 6 to 11 days in a dosage of 0.1 microgram/kg/mn. The patients had a severe attack of asthma with problems with infusions and/or problems with nebulizations of beta 2-agonists and/or bronchial stasis. No local or systemic adverse effects were recorded. This mode of administration of beta 2-agonists proved extremely useful, either as single therapy or as part of a therapeutic protocol including antibiotics, steroids and theophylline. It avoids the problems met with administration of beta 2-agonists by the other routes and allows the child freedom of movement. The main indication is the severe attack of asthma that fails to respond to nebulizations. We suggest this new therapeutic method should be included in the therapeutic armamentarium for infantile asthma, although its exact place and indications need to be further defined by studies in a larger number of patients.

Administration, Inhalation↗
PubMed1990

[Detection of respiratory allergies using the Phadiatop test in children 1 to 6 years of age].

Phadiatop, a new test for detecting hypersensitivity to airborne allergens, was used in 83 children aged 9 months to 6 years with recurrent respiratory manifestations, i.e. recurrent expiratory obstruction and/or recurrent respiratory infections. A good correlation was found between this test and both the prick tests (95%) and the specific IgE assays (91% for RASTS of classes greater than or equal to 1, and 95% for RASTS of classes greater than or equal to 2). However, the correlation was less strong with the total IgE level (68%). The overall correlation with the specialist's prediction based on history and physical evaluation was excellent (94%). In this study, Phadiatop was found to have a 90% sensitivity and a 98% specificity. Furthermore, this test costs 40% less than the often used strategy combining skin tests and determinations of total and specific IgE levels. In the age group studied, Phadiatop is most useful above the age of two, since in younger patients true respiratory allergies are fairly infrequent in recurrent ENT and lower respiratory tract infections, whereas infections are far more common.

Child↗
PubMed1990

[Is there a consensus among specialists concerning asthma?].

A list of 30 questions--of which 25 were literal translations of the questions asked by R.L. Henry and A.D. Milner (British Medical Journal 1983, 287, 260-261) and 5 were new questions--was presented to 118 specialists of asthma selected among the members of the European Academy of Allergology. A consensus (more than 75% identical answers) was observed for 17 questions. Surprisingly, only 50% of French specialists perform lung function testing on one occasion, since concomitantly the importance of periodic evaluation of "breathing" was underscored. Comparison with answers given by British practitioners raises the question of why a chronic disease such as asthma is managed differently despite comparable severity. The urgent need for a definition of "good diagnostic and therapeutic practices in asthma" is pointed out.

Adolescent↗
PubMed1990

[Pneumopleurocutaneous fistula after inhalation of an ear of barley (Hordeum murinum)].

A 16-month-old boy developed a cutaneous swelling at the base of the right hemithorax with fever. The chest film showed evidence of a very slight pleural effusion and the xerography disclosed subcutaneous emphysema opposite the swelling. Three weeks earlier, the child had been found in a field with an ear of grain in his hand and apparently exhibited a transient episode of choking. An article published several years ago by an anglo saxon author, T.R. Cavens, on pneumocutaneous fistulas secondary to the inhalation of grasses suggested that our patient had a similar condition. The abscess was opened and an ear of barley (Hordeum murinum) was found. Less than ten comparable observations have been published in the literature. We recall a number of botanical facts explaining why an ear of Hordeum murinum can migrate only in the forward direction.

Edible Grain↗
PubMed1988

[In vitro diagnosis of food allergy. Correlations among different diagnostic methods].

Diagnosis of immediate-type food allergy (AA) needs several kinds of investigation. To make their respective values clearer, we have studied the correlations that may exist between clinical scores, prick-tests (PT), oral provocation tests (TPO), measurement of fixed IgE on the polynuclear basophils (TDBH) free, serum IgE (RAST) and lymphoblast transformation (TTB) in 105 patients aged from 5 months to 17 years 3 months, who were suspected of AA. The weakest tests were PT and TPO of which the use (or not) at first were the two possible diagnostic approaches for AA. The study of the linear correlations between the different diagnostic tests taken two by two showed that there was a statistically significant correlation - the only one that we found - between PT and RAST (p2 less than 0.001). Finally, the level of agreement between PT and TPO was 86%.

Adolescent↗
PubMed1987

[Various methods for the diagnosis of allergy in pediatrics. Some correlations between different tests].

We studied the correlations between the different methods of diagnosis of the immediate allergy, IgE-dependent, in two current cases of pediatric allergology. In the mites allergy, the best correlation is observed between the skin tests (IDR) and the Rast. During the food allergy, first we found the best correlations between the prick-tests (PT) and the oral challenge (TPO), then between the prick-tests and the Rast. In these two studies, we got no further element to the diagnosis from the direct test of human basophil degranulation (TDBH).

Adolescent↗
PubMed1985

[Results of an experiment in systematic prenatal screening for neural tube malformations by assay of alpha fetoproteins in dried blood samples (12,480 pregnancies)].

Measurement of alpha-fetoprotein (AFP) in eluate of dried blood was carried out in 12,480 pregnant women, between the 10th and 30th weeks of amenorrhea. In 348 cases, AFP level was greater than normal (greater than 99th centile). 225 control measurements were performed (123 women dropped out of the study). In 173 cases, the AFP level returned to normal (1.4% false positives). In 52 cases, AFP title remained above the 99th centile: in 8 cases, the fetus was malformed (4 anencephalics, 1 spina bifida, 1 hydrocephalus, 1 laparoschisis, 1 exomphalos). Of the 44 remaining cases, 26 were multiple pregnancies, 5 were cases of acute fetal distress, 7 false positives normalized when a second control was made, 5 false positives up to the end of pregnancy, and 1 spina bifida (normal ultrasound scan on two different occasions). During this prenatal screening, 7 false negatives (0.56%) not detected by AFP assay should be noted: 3 anencephalics, 2 spina bifida, 1 hydrocephalus, 1 exomphalos. In all cases except one, the AFP test was carried out too early (before the 10th week) or too late (after the 30th week). The authors stress that screening must be done during the precise period between the 16th and 20th weeks of amenorrhea, and that close collaboration with a competent ultrasonographist is necessary. In 5 cases of false negatives where AFP assay and ultrasound scan had been carried out, the two methods are compared. Measurement of AFP in eluate of dried blood thus seems a reliable test which could be the first stage in a plan for systematic prenatal screening for certain serious fetal malformations with high incidence (1,2% in the Midi-Pyrenees region).

Anencephaly↗
PubMed1985

[The delay of bone maturation is a favorable element in the prognosis of final height].

Final heights were studied in 54 children followed for several years for growth retardation with delayed puberty. At the time of the first visit (13 9/12 in boys, 11 10/12 +/- 13/12 in girls), growth retardation was -2.7 +/- 0.8 in boys and -2.8 +/- 0.8 SD in girls. Retardation of bone age with respect to chronological age was always significant (2 7/12 +/- 10/12 yrs in boys and 2 7/12 +/- 9/12 in girls). Catch-up, calculated in terms of standard deviation score (SDS) between the first visit score and the final height was established for each child, as was the prognosis of height according to 3 methods (Bayley, Tanner, Roche). There is a highly significant correlation (r = 0.49; p less than 0.001) between the ratio of delayed bone age/chronological age (BA/CA) and the height catch-up calculated in SDS. On the contrary there is no correlation between the ratio BA/CA and the final height. This lack of correlation may be explained by the role taken by others factors, especially the parents heights, as a significant correlation was found between the final heights, the fathers heights (r = 0.29) and the mothers heights (r = 0.36). Thus, delayed bone maturation may be considered as a favourable factor for the prognosis of adult height.

Adolescent↗